A5018574706- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Genomics and Rare Diseases
- Prenatal Screening and Diagnostics
- Cellular transport and secretion
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Signaling Pathways in Disease
- Monoclonal and Polyclonal Antibodies Research
- RNA regulation and disease
- Hematological disorders and diagnostics
- Cell Adhesion Molecules Research
- Chronic Lymphocytic Leukemia Research
- Preterm Birth and Chorioamnionitis
- Extracellular vesicles in disease
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Cancer, Hypoxia, and Metabolism
- Nitric Oxide and Endothelin Effects
- RNA Research and Splicing
- Angiogenesis and VEGF in Cancer
- Photosynthetic Processes and Mechanisms
- Glycosylation and Glycoproteins Research
- Blood disorders and treatments
Fukuoka University
2018-2025
Kyushu University
2012
Kyowa Kirin (Japan)
2004-2006
The University of Tokyo
2004
Abstract Purpose: Recent studies have revealed that fucosylated therapeutic IgG1s need high concentrations to compensate for FcγRIIIa-competitive inhibition of antibody-dependent cellular cytotoxicity (ADCC) by endogenous human plasma IgG. Here, we investigated whether ADCC nonfucosylated IgG1 is also influenced IgG in the same way as IgG1s. Experimental Design: Ex vivo upon CD20+ B cells was induced incubation whole blood with and/or anti-CD20 rituximab, and quantified measuring remaining...
Pathogenic variants of KCNQ2, which encode a potassium channel subunit, cause either benign (familial) neonatal epilepsy-B(F)NE)-or KCNQ2 encephalopathy (KCNQ2 DEE). We examined the characteristics variants.KCNQ2 pathogenic were collected from in-house data and two large disease databases with their clinical phenotypes. Nonpathogenic Genome Aggregation Database (gnomAD). Pathogenicity all was reevaluated information to exclude irrelevant variants. The cumulative distribution plots B(F)NE,...
Summary Plants monitor the light environment through informational photoreceptors that include phytochromes. In seedling de‐etiolation, phytochrome B (phyB), which is most important member of family, interacts with transcription factors to regulate gene expression and transduce signals. this study, we identified rrc1 ( reduced red‐light responses in cry1cry2 background 1 ), an Arabidopsis mutant impaired phyB‐mediated responses. A genetic analysis demonstrated RRC1 affected signaling a...
Abstract Aim This study aimed to assess amniotic fluid bacterial load using the copy number of 16S ribosomal deoxyribonucleic acid and clarify its association with perinatal outcomes. Methods retrospective diagnostic prognostic included 63 patients preterm labor suspected intra‐amniotic infection who underwent amniocentesis before 34 weeks gestation. We measured in 1 mL droplet digital polymerase chain reaction graded infections as Grade (G) 0, 1, 2, or 3. Case–control analysis was performed...
Abstract Syntaxin-binding protein 1 (STXBP1; also called MUNC18–1), encoded by STXBP1, is an essential component of the molecular machinery that controls synaptic vesicle docking and fusion. De novo pathogenic variants STXBP1 cause a complex set neurological disturbances, namely encephalopathy (STXBP1-E) includes epilepsy, neurodevelopmental disorders neurodegeneration. Several animal studies have suggested contribution GABAergic dysfunction in STXBP1-E pathogenesis. However,...
The scavenger receptor expressed by endothelial cells (SREC) was isolated from a human cell line and consists of two isoforms named SREC-I -II. Both have no significant homology to other types receptors. They contain 10 repeats epidermal growth factor-like cysteine-rich motifs in the extracellular domains unusually long C-terminal cytoplasmic with Ser/Pro-rich regions. domain binds modified low density lipoprotein mediates homophilic SREC-I/SREC-I or heterophilic SREC-I/SREC-II...
Abstract Missense and truncating variants in protocadherin 19 ( PCDH19 ) cause -related epilepsy. In this study, we aimed to investigate variations distributional characteristics the clinical implications of variant type We comprehensively collected missense from literature by sequencing six exons intron–exon boundaries our cohort. investigated distribution each using cumulative function tested for associations between types phenotypes. The patients was clearly different that healthy...
Many countries, including Japan, are experiencing declining birth rates. Assisted reproductive technologies have consistently demonstrated good results in resolving infertility. Although the development of fertilized eggs into blastocysts has been recognized as a crucial step assisted technologies, involved mechanisms currently unclear. Here, we established new culture system for vitro blastocysts. In Transwell system, rate hatching from cultured with adipose-derived stem cells (ASCs) was...