A5021734242- HIV/AIDS Research and Interventions
- African Botany and Ecology Studies
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- HIV Research and Treatment
- HIV-related health complications and treatments
- Rangeland Management and Livestock Ecology
- HIV/AIDS drug development and treatment
- Nail Diseases and Treatments
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pneumocystis jirovecii pneumonia detection and treatment
- Aquatic Ecosystems and Biodiversity
- HIV, Drug Use, Sexual Risk
- Global Cancer Incidence and Screening
- Global Maternal and Child Health
- Biological Control of Invasive Species
- Adolescent Sexual and Reproductive Health
- COVID-19 diagnosis using AI
- Animal Diversity and Health Studies
- Mediterranean and Iberian flora and fauna
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Infectious Diseases and Mycology
- Healthcare Systems and Reforms
- Phonocardiography and Auscultation Techniques
Ifakara Health Institute
2018-2024
St. Francis Referral Hospital
2022-2024
Makerere University
1983-2022
Swiss Tropical and Public Health Institute
2020
Abstract Introduction Lifelong antiretroviral therapy (ART) improves health outcomes for HIV‐positive individuals, but is jeopardized by irregular clinic attendance and hence poor adherence. Loss to follow‐up (LTFU) typically defined retrospectively this may lead biased inferences. We assessed incidence of factors associated with LTFU, prospectively accounting recurrent LTFU episodes, in the Kilombero Ulanga Antiretroviral Cohort (KIULARCO) persons rural Tanzania. Methods included adults...
Diagnosis of chronic pulmonary aspergillosis (CPA) is based on a combination clinical symptomatology, compatible chest imaging findings, evidence Aspergillus infection and exclusion alternative diagnosis, all occurring for more than 3 months. Recently, rapid, highly sensitive specific point-of-care lateral flow device (LFD) has been introduced the detection Aspergillus-specific immunoglobulin (Ig)G, especially in resource-limited settings where CPA underdiagnosed often misdiagnosed as...
Importance Agreement in lung ultrasonography findings between clinicians using a handheld ultrasonographic device and expert sonographers high-end machine has not been studied sub-Saharan Africa. Objective To determine the agreement diagnoses primary care trained ultrasonography, board-certified sonographers, senior physicians. Design, Setting, Participants This cross-sectional single-center study was conducted from February 1, 2022, to April 30, 2023 at referral center rural Tanzania....
Cryptococcal antigen (CrAg) screening in persons with advanced HIV/AIDS is recommended to prevent death. Implementing CrAg only outpatients may underestimate the true prevalence and decrease its potential impact. Our previous 12-month survival/retention CrAg-positive not treated fluconazole was 0%.HIV testing offered all antiretroviral therapy-naive hospitalized patients Ifakara, Tanzania, followed by laboratory-reflex for CD4 <150 cells/μL. individuals were lumbar punctures, antifungals...
Abstract Introduction Monitoring HIV viral load (HVL) in people living with (PLHIV) on antiretroviral therapy (ART) is recommended by the World Health Organization. Implementation of HVL testing programs have been affected logistic and organizational challenges. Here we describe monitoring cascade a rural setting Tanzania compare turnaround times (TAT) between an on-site referral laboratory. Methods In nested study prospective Kilombero Ulanga Antiretroviral Cohort (KIULARCO) included PLHIV...
Real-time polymerase chain reaction (RT-PCR) remains the gold standard for detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study tested performance a pooled testing strategy RT-PCR and its cost-effectiveness. In total, 1280 leftover samples collected between 19 April 6 May 2021 were in 128 pools 10 each, out which 16 positive. The positivity rate unpooled was 1.9% (24/1280). After parallel using individual strategies, positive agreement 100% negative 99.8%....
Summary Background Cryptococcal meningitis accounts for 15% of all AIDS mortality globally. Most cases in low‐ and middle‐income countries are treated with fluconazole monotherapy, which is associated a high mortality. New available therapies needed. Short‐course amphotericin B has been shown to be safe efficient therapeutic option. Sertraline vitro fungicidal activity against Cryptococcus bi‐directional synergy fluconazole. Methods We conducted an open‐label clinical trial assess the safety...
Abstract Background We assessed the prevalence, incidence, and predictors of renal impairment among people living with HIV (PLWHIV) in rural Tanzania. Methods In a cohort PLWHIV aged ≥15 years enrolled from January 2013 to June 2016, we association between (estimated glomerural filtration rate &lt; 90 mL/min/1.73 m2) at enrollment during follow-up demographic clinical characteristcis using logistic regression Cox proportional hazards models. Results Of 1093 PLWHIV, 172 (15.7%) had...
Mortality assessment in cohorts with high numbers of persons lost to follow-up (LTFU) is challenging settings limited civil registration systems. We aimed assess mortality a clinical cohort (the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO)) human immunodeficiency virus (HIV)-infected rural Tanzania, accounting for unseen deaths among participants LTFU. included adults enrolled 2005-2015 traced nonrandom sample those estimated using Kaplan-Meier methods 1) routinely captured data...
Lung cancer is a leading cause of cancer-related deaths in Uganda. In this study, we aimed to describe the baseline characteristics and survival patients with lung at Uganda Cancer Institute (UCI).We retrospectively reviewed medical records all histological diagnosis registered UCI between January 2008 August 2018. Data on demographic, clinical, treatment characteristics, vital status were abstracted analyzed. Patients undocumented contacted through phone calls. We determined as time from...
Background Uganda adopted the HIV Test and Treat in 2016. There is paucity of data about its implementation among hospitalized patients. We aimed to determine proportion patients initiating anti-retroviral therapy (ART) during hospitalization, barriers mortality outcome. Methods In this mixed methods cohort study, we enrolled with a recent diagnosis from three public hospitals Uganda. collected on clinical characteristics, ART initiation reasons for failure initiate ART, as well 30 day...
Abstract Background Information about burden, characteristics, predictors, and outcomes of advanced human immunodeficiency virus disease (AHD) is scarce in rural settings sub-Saharan Africa. Human (HIV) infections associated deaths remain high despite specific guidelines issued by the World Health Organization (WHO). Methods Burden AHD 6-month death/loss to follow-up (LTFU) were described among 2498 antiretroviral therapy (ART)–naive nonpregnant people with HIV (PWH) aged &gt;15 years...
The extent to which drug-drug interactions (DDIs) between antiretrovirals (ARVs) and co-medications are recognized managed has not been thoroughly evaluated in limited-resource settings.This prospective questionnaire-based study aimed determine the prevalence risk factors for unrecognized/incorrectly DDIs people living with HIV followed-up at Chronic Diseases Clinic of Ifakara (CDCI) enrolled Kilombero Ulanga Antiretroviral Cohort (KIULARCO).We prospectively included ARV-treated adults...
Abstract Background The aim of this study was to evaluate the recovery rate left ventricular systolic function women diagnosed with peripartum cardiomyopathy receiving specialized care in rural Tanzania. Methods In observational study, at a referral center Tanzania between December 2015 and September 2021 were included. Women February followed prospectively, those January tracked back for follow-up echocardiography. All participants received clinical examination, comprehensive...