A5088778414- Chronic Lymphocytic Leukemia Research
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Cervical Cancer and HPV Research
- Autophagy in Disease and Therapy
- Protein Degradation and Inhibitors
- Calcium signaling and nucleotide metabolism
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- S100 Proteins and Annexins
- PI3K/AKT/mTOR signaling in cancer
- Antifungal resistance and susceptibility
- Mitochondrial Function and Pathology
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Multiple Myeloma Research and Treatments
The University of Texas MD Anderson Cancer Center
2002-2023
Scripps MD Anderson Cancer Center
2020
The University of Texas Health Science Center at Houston
2015
Baylor College of Medicine
2000-2011
Sunnybrook Health Science Centre
2007
University of Toronto
2007
Children's Cancer Center
2000-2001
Texas Children's Hospital
2000-2001
University of Delhi
1989
Abstract Purpose: Survival of CLL cells due to the presence Bcl-2 and Mcl-1 has been established. Direct inhibition by venetoclax indirect targeting with transcription inhibitors have successful approaches for CLL. AMG-176 is a selective direct antagonist Mcl-1, which shown efficacy in several hematologic malignancies; however, its effect on elusive. We evaluated biological molecular effects primary cells. Experimental Design: Using samples from patients (n = 74) CLL, we tested normal...
Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity,is frequently altered in human cancers including mantle cell lymphoma (MCL). Loss of ATM is linked to accumulation nonfunctional mitochondria and defective mitophagy, both murine thymocytes A-T cells. However, the mechanistic role cancer mitophagy unknown. Here, we provide evidence that FCCP-induced MCL other lines dependent on but independent its function. While Granta-519 cells possess single...
Several MCL-1 inhibitors (MCL-1i), including AMG-176 and AZD5991, have shown promise in preclinical studies are being tested for the treatment of hematologic malignancies. A unique feature these agents is induction stability Mcl-1 protein; however, precise mechanism unknown. We aim to study MCL-1i-induced protein stability.Using several B-cell leukemia lymphoma cell lines primary chronic lymphocytic (CLL) lymphocytes, we evaluated molecular events associated with half-life, reverse-phase...
Serum response factor (SRF) is an essential regulator of myogenic and neurogenic genes the ubiquitously expressed immediate-early genes. The purpose this study to determine SRF expression pattern in murine pancreas examine role pancreatic gene expression. Immunohistochemical analysis wild-type LacZ staining from knock-in animals showed that restricted β cells. bound rat insulin promoter II (RIP II) serum element, element conserved both I promoters. activated RIP II, binding exon 5-encoded...
// Aloke Sarkar 1 , Kumudha Balakrishnan 1, 3, 4 Jefferson Chen Viralkumar Patel Sattva S. Neelapu 2 John McMurray Varsha Gandhi Department of Experimental Therapeutics, The University Texas Health Science Center, Houston, Texas, USA Lymphoma and Myeloma, 3 Leukemia, UT MD Anderson Cancer Graduate School Biomedical Sciences, Correspondence to: Gandhi, e-mail: vgandhi@mdanderson.org Keywords: lymphoma, MCL, pro-caspase-3, Zn-ligands, B-PAC-1 Received: November 13,...
Vigorous host immune reactivity to neuroblastoma may correlate with better prognosis, but identification of human cytotoxic T-lymphocyte (CTL) responses has been relatively unsuccessful. We generated neuroblastoma-reactive CTL lines from two leukocyte antigen (HLA) A2 + patients by stimulation peripheral blood lymphocytes (PBLs) irradiated autologous tumor cells pretreated interferon-γ in the presence low concentrations interleukin-2 (5 U/mL). These lyse do not kill HLA mismatched allogeneic...
Abstract Ataxia telangiectasia mutated (ATM) is obligatory to initiate cellular responses DNA double-strand breaks and repair preserve genomic integrity while loss of ATM leads increased intracellular reactive oxygen species (ROS), accumulation aberrant mitochondria, leading abnormal mitochondrial homeostasis thereby exasperate cancer progression. frequently altered in several human cancers including 20-50% mantle cell lymphoma (MCL). Despite known induce global autophagy certain cells, the...
Abstract The serine/threonine protein kinase Ataxia telangiectasia mutated (ATM), plays a critical role in DNA damage response specifically to agents that induce double strand breaks. Recently, mitochondrial autophagy (mitophagy)-associated non-nuclear functions have been attributed ATM AT fibroblast (Valentin-Vega YA et al., Blood 119: 1490; 2012). Our investigations suggested similar of mantle cell lymphoma (MCL) lines (Sarkar, A Proc. AACR, 74: # 313; 2014). This is clinically important,...