A5082386891- Cytokine Signaling Pathways and Interactions
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Parasites and Host Interactions
- Tuberculosis Research and Epidemiology
- Parasitic infections in humans and animals
- interferon and immune responses
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- RNA Research and Splicing
- Clostridium difficile and Clostridium perfringens research
- T-cell and B-cell Immunology
- Infectious Diseases and Tuberculosis
- Parasite Biology and Host Interactions
- IL-33, ST2, and ILC Pathways
- Salmonella and Campylobacter epidemiology
- Viral Infections and Immunology Research
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Heat shock proteins research
- Erythrocyte Function and Pathophysiology
- Biomarkers in Disease Mechanisms
- Multiple Sclerosis Research Studies
Medical College of Wisconsin
2024
Osaka International University
2013-2022
Osaka University
2013-2022
All India Institute of Medical Sciences Jodhpur
2019-2020
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2006-2017
Soka University
2016
Immune Regulation (United Kingdom)
2013
The AT-rich interactive domain-containing protein 5a (Arid5a) plays a critical role in autoimmunity by regulating the half-life of Interleukin-6 (IL-6) mRNA. However, signaling pathways underlying Arid5a-mediated regulation IL-6 mRNA stability are largely uncharacterized. Here, we found that during early phase lipopolysaccharide (LPS) stimulation, NF-κB and an NF-κB-triggered IL-6-positive feedback loop activate Arid5a gene expression, increasing expression via stabilization Subsequently,...
Aryl hydrocarbon receptor (AHR) plays critical roles in various autoimmune diseases such as multiple sclerosis by controlling interleukin-17 (IL-17)–producing T-helper (T H 17) and regulatory T cells. Although transcription factors cytokines have been identified key participants 17 generation, the role of microRNAs this process is poorly understood. In study, we found that expression microRNA (miR)-132/212 cluster up-regulated AHR activation under 17-inducing, but not T-inducing conditions....
Balance in signal transducer and activator of transcription (STAT) activation is a key factor regulating the fate naive CD4+ T cells. Here, we demonstrate that AT-rich interactive domain-containing protein 5a (Arid5a) cells directs to differentiate into inflammatory cells, especially Th17 through selective stabilization Stat3 (but not Stat1 Stat5) mRNA an IL-6–dependent manner. Loss Arid5a led reduction STAT3 level under Th17-polarizing conditions, whereas STAT1 STAT5 Arid5a-deficient were...
Abstract Aryl hydrocarbon receptor (Ahr), a transcription factor, plays critical role in autoimmune inflammation of the intestine. In addition, microRNAs (miRNAs), small non-coding oligonucleotides, mediate pathogenesis inflammatory bowel diseases (IBD). However, precise mechanism and interactions these molecules IBD have not yet been investigated. We analyzed Ahr Ahr-regulated miRNAs colonic inflammation. Our results show that deficiency intestinal epithelial cells mice exacerbated dextran...
Background. Symptoms and signs of neurocysticercosis (NCC) are nonspecific depend upon several factors, including the host immune response to parasite. Toll-like receptors (TLRs) play an important role in innate immunity. Susceptibility humans NCC relation TLR polymorphism is unknown. The present study examines TLR4 human its symptomatic disease. Methods. A total 140 patients with (82 [ie, active epilepsy] 58 asymptomatic) 150 healthy control subjects were examined for Asp299Gly Thr399Ile...
Significance Septic shock is one of the major causes morbidity and mortality throughout world. Despite extensive efforts, septic remains a medical challenge. In this study, using Arid5a-deficient mice, we demonstrated critical role protein in lipopolysaccharide (LPS)-induced through regulation IFN-γ expression T cells by preventing mRNA degradation its transcription factor T-bet. Further, identified conserved stem loop structure at 3′UTR T-bet required for binding Arid5a during action. Our...
Objectives: To determine the expression of proinflammatory and anti-inflammatory cytokines in lymphocytes from progressive recovery phases Guillain-Barre ´syndrome (GBS) after stimulation with Campylobacter jejuni outer membrane proteins.Design: Case-control study.
Abstract AT‐rich interactive domain‐containing protein 5a (Arid5a) is an RNA‐binding (RBP) required for autoimmunity via stabilization of interleukin‐6 ( Il6 ) and signal transducer activator transcription 3 STAT3 mRNAs. However, the roles Arid5a in Th17 cells its association with remain unknown. Here, we show that levels OX40 are correlated CD4 + T under conditions IL‐6‐dependent manner. Lack reduced expression repressed IL‐17 production response to ligation. stabilized mRNA by recognizing...
SUMMARY Matrix metalloproteinases (MMPs) are the major endopeptidases involved in proteolysis of blood brain barrier (BBB) during central nervous system (CNS) infections. The present study detected serum levels and activities MMP-2 MMP-9 patients with neurocysticercosis (NCC) their association symptomatic disease. In total, 68 individuals NCC (36 active seizures 32 asymptomatic individuals) 37 healthy controls were enrolled for study. Serum measured by ELISA gel zymography respectively. Mean...
Sinha S, Prasad KN, Jain D, Nyati KK, Pradhan Agrawal S. Immunoglobulin IgG Fc-receptor polymorphisms and HLA class II molecules in Guillain–Barré syndrome.Acta Neurol Scand: 2010: 122: 21–26.© 2010 The Authors Journal compilation © Blackwell Munksgaard. Objective – To analyze host genetic factors immunoglobulin G Fc receptors (FcγRs) human leukocyte antigen (HLA) GBS patients. Methods FcγRIIA, IIIA IIIB were studied 80 each patients healthy controls by allele specific PCR. DRβ1 DQβ1 typing...
Thalidomide and its derivatives, collectively referred to as immunomodulatory drugs (IMiDs), are effective inhibitors of inflammation known inhibit TLR-induced TNFα production. The identification Cereblon the receptor for these compounds has led a rapid advancement in our understanding IMiD properties; however, there remain no studies addressing role mediating suppressive effect IMiDs on TLR responses. Here, we developed Cereblon-deficient mice using CRISPR-Cas9 system. cytokine responses...
Significance Obesity is now considered an epidemic problem worldwide. To develop effective interventions against obesity, we need to understand precisely the regulatory mechanism of adipogenesis, a process forming adipocytes from fibroblast cells. In this study, revealed that Arid5a protein regulates adipogenesis and development obesity in mice. inhibits by suppressing transcription peroxisome proliferator activated receptor gamma 2 (Ppar-γ2), which main facilitator adipogenesis. Further,...
Abstract The role of matrix metalloproteinases (MMPs) and cytokines in the pathogenesis Guillain‐Barré syndrome (GBS) largely remains unknown. We studied MMP‐2, MMP‐9, tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β) disease progression recovery patients with GBS. Sixty‐five GBS 68 healthy controls were enrolled study. Serum levels TNF‐α, IL‐1β analyzed by ELISA, activities MMPs measured zymography. Expression was higher progressive phase lower than controls. A positive correlation...