A5052655740- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Radiation Therapy and Dosimetry
- Nuclear Physics and Applications
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Particle Detector Development and Performance
- Atomic and Subatomic Physics Research
- Radiopharmaceutical Chemistry and Applications
- Numerical methods in inverse problems
- Seismic Imaging and Inversion Techniques
- Radiation Dose and Imaging
- Digital Radiography and Breast Imaging
- Model Reduction and Neural Networks
- CCD and CMOS Imaging Sensors
- Radioactive Decay and Measurement Techniques
- Radiation Effects in Electronics
- Graphite, nuclear technology, radiation studies
- Advanced X-ray Imaging Techniques
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2018-2025
Centre National de la Recherche Scientifique
2018-2025
Inserm
2018-2025
Université Claude Bernard Lyon 1
2018-2025
Centre Léon Bérard
2020-2024
Institut National des Sciences Appliquées de Lyon
2022-2024
Centre de Recherche en Cancérologie de Lyon
2022
Instituto de Física Corpuscular
2012-2020
Universitat de València
2012-2020
Institut de Physique des 2 Infinis de Lyon
2019-2020
Compton imaging devices have been proposed and studied for a wide range of applications. We developed camera prototype which can be operated with two or three detector layers based on monolithic lanthanum bromide ([Formula: see text]) crystals coupled to silicon photomultipliers (SiPMs), used proton verification in hadron therapy. In this work, we present the results obtained our laboratory tests radioactive sources simulation studies. Images [Formula: text]Na an text]Y successfully...
A Compton telescope for dose monitoring in hadron therapy is under development at IFIC. The system consists of three layers LaBr3 crystals coupled to silicon photomultiplier arrays. Na-22 sources have been successfully imaged reconstructing the data with an ML-EM code. Calibration and temperature stabilization are necessary prototype operation low coincidence rates. spatial resolution 7.8 mm FWHM has obtained first imaging tests.
Monte Carlo simulation of particle tracking in matter is the reference method field medical physics. It heavily used various applications such as 1) patient dose distribution estimation different therapy modalities (radiotherapy, protontherapy or ion therapy) for radio-protection investigations ionizing radiation-based imaging systems (CT, nuclear imaging), 2) development numerous detectors, X-ray (conventional CT, dual-energy, multi-spectral, phase contrast … ), (PET, SPECT, Compton Camera)...
Abstract Rigid patient motion can cause artifacts in single photon emission computed tomography (SPECT) images, compromising the diagnosis and treatment planning. Exponential data consistency conditions (eDCCs) are mathematical equations describing redundancy of exponential SPECT measurements. It has been recently shown that eDCCs be used to detect projections.
 This study aimed at developing a fully data-driven method based on estimate correct for translational SPECT.
 If...
Given the strong variations in sensitivity of Compton cameras for detection events originating from different points field view (FoV), correction is often necessary image reconstruction. Several approaches calculation matrix have been proposed literature. While most these models are easily implemented and can be useful many cases, they usually assume high angular coverage over scattered photon, which not case our prototype. In this work, we derived an analytical model that allows us to...
To identify range deviations by using Compton cameras (CCs), tomographic image reconstruction of CC data is needed. Within this context, usually performed maximum likelihood expectation maximization (MLEM), and more recently, the origin ensemble (OE) algorithm. In article, we investigate how MLEM OE affect precision accuracy estimated deviations. particular, focus on effects selection, statistical fluctuations, artifact reduction. The use external information beam path through a hodoscope...
Compton cameras are gamma-ray imaging systems which have been proposed for a wide variety of applications such as medical imaging, nuclear decommissioning or homeland security. In the design and optimization system Monte Carlo simulations play an essential role. this work, we propose generic module to perform analyses Camera is included in open-source GATE/Geant4 platform. Several digitization stages implemented within mimic performance most commonly employed detectors (e.g. monolithic...
Abstract Objective . We introduce a versatile methodology for the accurate modelling of PET imaging systems via Monte Carlo simulations, using Geant4 application tomographic emission (GATE) platform. Accurate involves incorporation complete analytical signal processing chain, called digitizer in GATE, to emulate different count rates encountered actual positron tomography (PET) systems. Approach The proposed approach consists two steps: (1) replicate detection chain real systems, covering...
The interest in using continuous monolithic crystals positron emission tomography (PET) has grown the last years. Coupled to silicon photomultipliers (SiPMs), detector can combine high sensitivity and resolution, two main factors be maximized a tomograph. In this work, position determination capability of comprised mm3 LYSO crystal coupled an -pixel array SiPMs is evaluated. 3D interaction γ-rays estimated analytical model light distribution including reflections on facets crystal. Monte...
Abstract The IRIS group at IFIC Valencia is developing a three-layer Compton camera for treatment monitoring in proton therapy. system composed of three detector planes, each made <?CDATA $\mathrm{LaBr_3}$?> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:mi mathvariant="normal">L</mml:mi> mathvariant="normal">a</mml:mi> mathvariant="normal">B</mml:mi> <mml:msub> mathvariant="normal">r</mml:mi> <mml:mn>3</mml:mn> </mml:msub> </mml:mrow> </mml:math>...
A method is proposed to model by a generative adversarial network the distribution of particles exiting patient during Monte Carlo simulation emission tomography imaging devices. The resulting compact neural then able generate patient, going towards detectors, avoiding costly particle tracking within patient. As proof concept, evaluated for single photon computed (SPECT) and combined with another modeling detector response function (ARF-nn). complete rotating SPECT acquisition can be...
Compton Cameras are electronically collimated photon imagers suitable for sub-MeV to few MeV gamma-ray detection. Such features desirable enable in vivo range verification hadron therapy, through the detection of secondary Prompt Gammas. A major concern with this technique is poor image quality obtained when incoming energy unknown. more than two detector planes (multi-layer Cameras) have been proposed as a solution, given that these devices incorporate signal sequences interactions...
Continuous crystals can potentially obtain better intrinsic detector spatial resolution compared to pixelated crystals, additionally providing depth of interaction (DoI) information from the light distribution. To achieve high performance sophisticated position estimation algorithms are required. There a number in literature applied different crystal dimensions and photodetectors. However, properties photodetector array geometries have an impact on algorithm performance. In this work we...
Detectors based on Silicon Photomultipliers (SiPMs) coupled to continuous crystals are being tested in medical physics applications due their potential high resolution and sensitivity. To cope with the granularity required for a very good spatial resolution, SiPM matrices large amount of elements needed. be able read information coming from each individual channel, dedicated ASICs employed. The VATA64HDR16 ASIC is 64-channel, charge-sensitive amplifier that converts collected charge into...
A Monte Carlo virtual source model named PHID (photon from Ion decay) that generates photons emitted in the complex decay chain process of alpha-emitter radionuclides is proposed, typically for use during simulation SPECT image acquisition.
Compton cameras (CCs) and collimated gamma are competing devices suitable for prompt detection in range verification of particle therapy. In this article, we evaluate the first approach from point view tomographic reconstruction step by comparing it to second. We clear any technological constraints considering a simple geometry, ideal detecting stages, mono-energetic synthetic phantom. To end, both analytic (filtered back-projection) iterative (list-mode maximum-likelihood...
Objective.Following previous works on virtual sources model with Generative Adversarial Network (GAN), we extend the proof of concept for generating back-to-back pairs gammas timing information, typically Monte Carlo simulation Positron Emission Tomography(PET) imaging.Approach.A conditional GAN is trained once from a low statistic in given attenuation phantom and enables generation various activity source distributions. training input set exiting phantom, tracked positron emitters,...
Within the frame of CLaRyS collaboration, we discuss assets using a reduced-intensity in vivo treatment control phase during one or few beam spots at beginning particle therapy session. By doing so can improve considerably conditions for secondary radiation detection and radiography. This also makes Time-of-Flight (ToF) resolutions 100 ps rms feasible both transmitted particles radiations, by means single-projectile counting mode beam-tagging monitor with time position registration. opens up...