Merve Yigin
A5005697882- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- thermodynamics and calorimetric analyses
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Prion Diseases and Protein Misfolding
- Vitamin C and Antioxidants Research
SLAC National Accelerator Laboratory
2021
Koç University
2020-2021
The COVID-19 pandemic has resulted in 198 million reported infections and more than 4 deaths as of July 2021 (covid19.who.int). Research to identify effective therapies for includes: (1) designing a vaccine future protection; (2) de novo drug discovery; (3) identifying existing drugs repurpose them immediate treatments. To assist repurposing design, we determine two apo structures severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease at ambient temperature by serial...
Oligomerization of Pr55
Abstract The COVID19 pandemic has resulted in 25+ million reported infections and nearly 850.000 deaths. Research to identify effective therapies for includes: i) designing a vaccine as future protection; ii) structure-based drug design; iii) identifying existing drugs repurpose them immediate treatments. To assist repurposing design, we determined two apo structures of Severe Acute Respiratory Syndrome CoronaVirus-2 main protease at ambienttemperature by Serial Femtosecond X-ray...
ABSTRACT HIV-1 continues to be a global health concern since AIDS was first recognized by the World Health Organization (WHO). It is estimated that there were 38 million people infected with and 1.5 deaths in 2019 alone. A better understanding of details HIV late-stage life cycle, involving Pr55 Gag attachment membrane for further oligomerization release virion, will provide us new avenues potential treatment. Inositol hexakisphosphate (IP6) an abundant endogenous cyclitol molecule its...
Abstract HIV-1 continues to be a global health concern since AIDS was first recognized by the World Health Organization (WHO). It is estimated that there were 38 million people infected with and 1.5 deaths in 2019 alone. A better understanding of details HIV late-stage life cycle, involving Pr55 Gag attachment membrane for further oligomerization release virion, will provide us new avenues potential treatment. Inositol hexakisphosphate (IP6) an abundant endogenous cyclitol molecule its...