A5004754985- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Coronary Artery Anomalies
- Atrial Fibrillation Management and Outcomes
- Autophagy in Disease and Therapy
- Obstructive Sleep Apnea Research
- Photoacoustic and Ultrasonic Imaging
- Cardiac tumors and thrombi
- Aortic Thrombus and Embolism
- Cardiac Fibrosis and Remodeling
- Heme Oxygenase-1 and Carbon Monoxide
- Financial Reporting and Valuation Research
- Cardiac Structural Anomalies and Repair
- Neuroscience of respiration and sleep
- Cardiovascular Issues in Pregnancy
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Sleep and Wakefulness Research
- Acute Kidney Injury Research
- Calcium signaling and nucleotide metabolism
- Cardiac pacing and defibrillation studies
- Cardiac Ischemia and Reperfusion
Osaka University
2019-2024
Toyonaka Municipal Hospital
2024
National Sagamihara Hospital
2023
Kamiichi General Hospital
2023
Osaka Police Hospital
2013-2017
Mitochondrial deoxyribonucleic acid, containing the unmethylated cytidine-phosphate-guanosine motif, stimulates Toll-like receptor 9 to induce inflammation and heart failure. A small chemical, E6446 [(6-[3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl]benzo[d]oxazole)], is a specific inhibitor in cardiomyocytes. In this study, we showed that exerts beneficial effects for prevention treatment of pressure overload-induced failure mice. When administered before operation...
Atrial functional mitral and tricuspid regurgitation due to atrial fibrillation (AF) are common causes of heart failure with preserved ejection fraction, but standard treatment conventional diuretics can often lead renal dysfunction. Kampo Goreisan, a traditional Eastern-Asian herbal medicine that regulates body water balance via the aquaporin-incorporated reabsorption system be used as an alternative therapy without causing burden. In this report, we describe case successful Goreisan...
Drug-eluting stents (DES) have reduced late loss and target lesion revascularization through the inhibition of neointimal hyperplasia, but instead increased risk very stent failure due to incomplete coverage neoatherosclerosis. Although newer DES are more effective safer than first-generation DES, difference in condition stented lesions between Resolute zotarolimus-eluting (R-ZES) Endeavor (E-ZES) on angioscopy has not been reported.Consecutive patients who received R-ZES (n=46) or E-ZES for...
Heart failure has high morbidity and mortality in the developed countries. Autophagy is important for quality control of proteins organelles heart. Rubicon (Run domain Beclin-1-interacting cysteine-rich domain-containing protein) been identified as a potent negative regulator autophagy endolysosomal trafficking. The aim this study was to investigate vivo role Rubicon-mediated endosomal trafficking We generated cardiomyocyte-specific Rubicon-deficient mice subjected pressure overload by means...
Abstract Heart failure is a leading cause of mortality in developed countries. Cell death key player the development heart failure. Calcium-independent phospholipase A 2 β (iPLA β) produces lipid mediators by catalyzing lipids and induces nuclear shrinkage caspase-independent cell death. Here, we show that lysophosphatidylserine generated iPLA necrotic cardiomyocyte death, as well contractile dysfunction mediated through its receptor, G protein-coupled receptor 34 (GPR34)....
Aortic mural thrombus is associated with atherosclerosis in a vast majority of cases and could result multiple organ damage, leading to higher morbidity mortality rates. Although aspirin be effective for primary prevention atherosclerosis-induced aortic thrombus, resistance, which refers the inadequate response therapy, allows progression thrombus. Classically, warfarin an treatment thromboembolic diseases, while recent years, direct oral anticoagulants (DOACs) have shown superior safety...
Abstract Cor triatriatum sinister (CTS) is a relatively rare congenital condition characterized by an abnormal septum dividing the left atrium, morphologically presenting as three atria. Although most individuals with heart failure related to CTS undergo surgical treatment in childhood, those larger fenestrations may remain asymptomatic until they reach age where surgery less viable, challenges. In our case study, we report on elderly woman who declined all invasive treatments and developed...
Obstructive sleep apnoea syndrome (O-SAS) induces excessive activity of the sympathetic nervous system, resulting in secondary hypertension. Although continuous positive airway pressure (CPAP) is first-line therapy for O-SAS, poor adherence to CPAP uncontrollable resistant We present a case O-SAS-related hypertension successfully treated with sacubitril/valsartan alone. Polysomnography before treatment showed markedly increased apnoea-hypopnoea index (44.8/hour). While receiving and...
Yellow plaques detected by coronary angioscopy have been regarded as vulnerable and associated with distal embolization or slow/no-flow phenomenon during intervention. This is the first report that compared findings of near-infrared spectroscopy (NIRS) in a patient who suffered no-flow A 41-year-old male silent myocardial ischemia received Coronary angiogram revealed diffuse stenosis right artery. Target lesion was examined NIRS angioscopy. can detect lipid core plaque, which presented an...
Although long-term rather than short-term efficacy of new coronary stents is very important for patients, it usually evaluated by the one-year results randomized comparison trials. When Cypher-sirolimus-eluting stent (C-SES) was compared with Endeavor-zotarolimus-eluting (E-ZES), significantly better C-SES; however, 5-year E-ZES due to higher event rate in C-SES after one year. angioscopic images those at year demonstrated neointimal coverage and suggested risk complications E-ZES, many...
Drug-eluting stents (DESs) in comparison with bare metal (BMSs) have reduced early target lesion revascularization (TLR) through exerting an inhibitory effect on smooth muscle cell hyperplasia but also increased the risk of stent thrombosis and TLR after 1 year, other words, very-late failure (VLSF). Neoatherosclerosis or atherosclerosis progression is thought to be major mechanism regarded as a ‘final common pathway VLSF.’ Atherosclerosis can detected by various intracoronary imaging...