Józef Roskosz

ORCID: 0000-0001-6434-7394
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About
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Research Areas
  • Thyroid Cancer Diagnosis and Treatment
  • Thyroid and Parathyroid Surgery
  • Thyroid Disorders and Treatments
  • Neuroendocrine Tumor Research Advances
  • Radiopharmaceutical Chemistry and Applications
  • BRCA gene mutations in cancer
  • Adrenal and Paraganglionic Tumors
  • Head and Neck Anomalies
  • Genetic factors in colorectal cancer
  • Pituitary Gland Disorders and Treatments
  • Radiation Dose and Imaging
  • Cancer, Hypoxia, and Metabolism
  • Neuroblastoma Research and Treatments
  • Nutrition and Health Studies
  • Global Cancer Incidence and Screening
  • Lung Cancer Research Studies
  • Protease and Inhibitor Mechanisms
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Nutrition, Genetics, and Disease
  • Advanced Differential Geometry Research
  • Gene expression and cancer classification
  • Ophthalmology and Eye Disorders
  • PI3K/AKT/mTOR signaling in cancer
  • Cancer-related Molecular Pathways
  • Bone health and treatments

The Maria Sklodowska-Curie National Research Institute of Oncology
2001-2020

Centrum Onkologii
2001-2018

Medical University of Silesia
2009

Lateral ankle sprains (LASs) are the most prevalent musculoskeletal injury in physically active populations. They also have a high prevalence general population and pose substantial healthcare burden. The recurrence rates of LASs high, leading to large percentage patients with LAS developing chronic instability. This chronicity is associated decreased physical activity levels quality life associates increasing post-traumatic osteoarthritis, all which generate financial costs that larger than...

10.2967/jnumed.106.035535 article EN Journal of Nuclear Medicine 2007-06-01

PURPOSE: The study was undertaken to evaluate the frequency of inherited medullary thyroid carcinoma (MTC) among patients with apparent sporadic disease. A stepwise algorithm used depending on clinical indices and age patient at MTC diagnosis. PATIENTS AND METHODS: One hundred sixteen verified by postoperative pathologic examination were subjected genetic analysis RET exons 10, 11, 13, 14, 16 means polymerase chain reaction, restriction endonuclease digestion, DNA sequencing. RESULTS: Among...

10.1200/jco.2001.19.5.1374 article EN Journal of Clinical Oncology 2001-03-01

Significant advances have been made in thyroid can­cer research recent years, therefore relevant clinical guidelines need to be updated. The current Polish "Diagnostics and Treatment of Thyroid Carcinoma" formulated at the "Thyroid Cancer Other Malignancies Endocrine Glands" conference held Wisła November 2015 [1].

10.5603/ep.2018.0014 article EN cc-by-nc-nd Endokrynologia Polska 2018-02-06

The aim of this study is to compare the effectiveness 131I therapy between three groups DTC patients who received 30, 60 or 100 mCi for thyroid remnant ablation after total thyroidectomy and were postoperatively judged with low risk cancer recurrence. project was designed as a two-stage, prospective randomized clinical trial. In 1998-2001 in early comparison treatment 30 vs suggested lower activity be less effective, whereas 2003-2005 showed no significant differences. present comprises...

10.1186/1756-6614-3-9 article EN cc-by Thyroid Research 2010-01-01

In 30-50% of patients with metastatic non-medullary thyroid cancer the metastases are not radioiodine-avid and so there is no effective treatment. Retinoids have demonstrated inhibition tumor growth induction radioiodine uptake. The aim our study was to assess benefits retinoic acid (RA) treatment re-differentiate non-functional NMTC metastases.In this prospective study, 53 non avid disease (45) or hyperthyroglobulinemia (8) were treated 13-cis-retinoic (13-CRA) [1.0 mg/kg/day over 1st week...

10.1186/1756-6614-2-8 article EN cc-by Thyroid Research 2009-08-01

Adequate postoperative risk assessment currently constitutes the principle of DTC treatment and further management. The aim study - a retrospective factors influencing relapse.The group consisted 510 staged pT1b-T4N0-N1M0, in whom total thyroidectomy complementary radioiodine (RAI) were carried out. In 71% papillary thyroid cancer was diagnosed, whereas remaining 29% follicular carcinoma. Based on TNM classification from 1997, T1 feature diagnosed 11.6%, T2 35.1%, T3 8.4%, T4 9,4%, while...

10.5603/ep.2016.0001 article EN cc-by-nc-nd Endokrynologia Polska 2016-02-17

Although postoperative radioiodine (RAI) therapy has been used in patients with differentiated thyroid carcinoma (DTC) for many years, there is still lack of data defining the timing RAI administration. A retrospective analysis was carried out to answer question whether time treatment demonstrated any impact on long-term outcomes, particularly low-risk DTC.The analyzed group involved 701 DTC staged pT1b-T4N0-N1M0, who underwent total thyroidectomy and therapy. According interval between...

10.1007/s13139-019-00608-8 article EN cc-by Nuclear Medicine and Molecular Imaging 2019-09-05

The value of postoperative radiotherapy in the treatment medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer question whether adjuvant showed any impact on risk local recurrence and there were differences response between hereditary sporadic MTC. Methods A retrospective analysis involved 254 MTC patients, among them 73 patients with a disease. Two hundred twenty-four including 43 persons at high relapse, underwent only initial...

10.1530/ec-19-0387 article EN cc-by-nc-nd Endocrine Connections 2020-01-01

Introduction: Radioactive iodine (RAI) therapy may induce or worsen orbitopathy (GO) in Graves’ disease (GD). The aim of this study was a prospective assessment the risk GO exacerbation GD patients cohort submitted to RAI for hyperthyroidism. Material and methods: 208 consecutive treated with 131I 2007 were enrolled. analysis performed on 156 strictly monitored one year. Glucocorticosteroid (GCS) prophylaxis administered if symptoms history present, cases tobacco smokers even without...

10.5603/ep.2014.0006 article EN Endokrynologia Polska 2014-02-19
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