A5044375389- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- Head and Neck Anomalies
- Neuroendocrine Tumor Research Advances
- Bioinformatics and Genomic Networks
- PI3K/AKT/mTOR signaling in cancer
- Radiation Dose and Imaging
- Gene expression and cancer classification
- Genetic factors in colorectal cancer
- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Ion channel regulation and function
- Marine Biology and Environmental Chemistry
- Bipolar Disorder and Treatment
- Global Cancer Incidence and Screening
- Parathyroid Disorders and Treatments
- S100 Proteins and Annexins
- Carcinogens and Genotoxicity Assessment
- Advanced Radiotherapy Techniques
- Advanced Breast Cancer Therapies
- Medication Adherence and Compliance
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pituitary Gland Disorders and Treatments
State Higher Vocational School in Głogów
2024
The Maria Sklodowska-Curie National Research Institute of Oncology
2013-2023
Centrum Onkologii
2001-2018
Endocrine Society
2016
Lateral ankle sprains (LASs) are the most prevalent musculoskeletal injury in physically active populations. They also have a high prevalence general population and pose substantial healthcare burden. The recurrence rates of LASs high, leading to large percentage patients with LAS developing chronic instability. This chronicity is associated decreased physical activity levels quality life associates increasing post-traumatic osteoarthritis, all which generate financial costs that larger than...
The guidelines Thyroid Cancer 2022 are prepared based on previous Polish recommendations updated in 2018. They consider international - American Association (ATA) 2015 and National Comprehensive Network (NCCN); however, they adapted according to the ADAPTE process. strength of quality scientific evidence assessed GRADE system ATA NCCN recommendations. core changes made is inclusion results those studies that have already proven themselves prospectively. These extensions allow de-escalation...
PURPOSE: The study was undertaken to evaluate the frequency of inherited medullary thyroid carcinoma (MTC) among patients with apparent sporadic disease. A stepwise algorithm used depending on clinical indices and age patient at MTC diagnosis. PATIENTS AND METHODS: One hundred sixteen verified by postoperative pathologic examination were subjected genetic analysis RET exons 10, 11, 13, 14, 16 means polymerase chain reaction, restriction endonuclease digestion, DNA sequencing. RESULTS: Among...
Significant advances have been made in thyroid cancer research recent years, therefore relevant clinical guidelines need to be updated. The current Polish "Diagnostics and Treatment of Thyroid Carcinoma" formulated at the "Thyroid Cancer Other Malignancies Endocrine Glands" conference held Wisła November 2015 [1].
Selection of novel molecular markers is an important goal cancer genomics studies. The aim our analysis was to apply the multivariate bioinformatical tools rank genes – potential papillary thyroid (PTC) according their diagnostic usefulness. We also assessed accuracy benign/malignant classification, based on gene expression profiling, for PTC. analyzed a 180-array dataset (90 HG-U95A and 90 HG-U133A oligonucleotide arrays), which included collection 57 PTCs, 61 benign tumors, 62 apparently...
The aim of this study is to compare the effectiveness 131I therapy between three groups DTC patients who received 30, 60 or 100 mCi for thyroid remnant ablation after total thyroidectomy and were postoperatively judged with low risk cancer recurrence. project was designed as a two-stage, prospective randomized clinical trial. In 1998-2001 in early comparison treatment 30 vs suggested lower activity be less effective, whereas 2003-2005 showed no significant differences. present comprises...
In 30-50% of patients with metastatic non-medullary thyroid cancer the metastases are not radioiodine-avid and so there is no effective treatment. Retinoids have demonstrated inhibition tumor growth induction radioiodine uptake. The aim our study was to assess benefits retinoic acid (RA) treatment re-differentiate non-functional NMTC metastases.In this prospective study, 53 non avid disease (45) or hyperthyroglobulinemia (8) were treated 13-cis-retinoic (13-CRA) [1.0 mg/kg/day over 1st week...
Abstract Background Differential diagnosis between malignant follicular thyroid cancer (FTC) and benign adenoma (FTA) is a great challenge for even an experienced pathologist requires special effort. Molecular markers may potentially support differential FTC FTA in postoperative specimens. The purpose of this study was to derive molecular post-operative diagnosis, the form simple multigene mRNA-based classifier that would differentiate tissue samples. Methods A created based on combined...
Adequate postoperative risk assessment currently constitutes the principle of DTC treatment and further management. The aim study - a retrospective factors influencing relapse.The group consisted 510 staged pT1b-T4N0-N1M0, in whom total thyroidectomy complementary radioiodine (RAI) were carried out. In 71% papillary thyroid cancer was diagnosed, whereas remaining 29% follicular carcinoma. Based on TNM classification from 1997, T1 feature diagnosed 11.6%, T2 35.1%, T3 8.4%, T4 9,4%, while...
Although postoperative radioiodine (RAI) therapy has been used in patients with differentiated thyroid carcinoma (DTC) for many years, there is still lack of data defining the timing RAI administration. A retrospective analysis was carried out to answer question whether time treatment demonstrated any impact on long-term outcomes, particularly low-risk DTC.The analyzed group involved 701 DTC staged pT1b-T4N0-N1M0, who underwent total thyroidectomy and therapy. According interval between...
Available methods, including serum thyroglobulin (Tg) measurement and whole-body scan (WBS) performed after radioiodine administration, allow for a precise diagnostics in differentiated thyroid cancer (DTC). However, some asymptomatic patients demonstrate negative WBS despite high Tg concentration. In these subjects, fluorodeoxyglucose-positron emission tomography (FDG-PET) should be considered. The primary aim of our study was to evaluate diagnostic value FDG-PET hyperthyroglobulinemia....
Radioiodine [RAI]-resistant advanced and progressive differentiated thyroid cancer [DTC], although rare, constitutes a real challenge as its prognosis is poor available therapeutic options, until now, have been limited. Discovery of crucial role distinct tyrosine kinases in DTC pathogenesis opened up new options systemic treatment. Lenvatinib an oral potent multi kinase inhibitor [MKI] different growth factor receptors including VEGFR1/Flt-1, VEGFR2/KDR, VEGFR3, FGFR1,2,3,4, PDGFR-β well RET...
The value of postoperative radiotherapy in the treatment medullary thyroid carcinoma (MTC) has not been unequivocally demonstrated. Therefore our study aimed to answer question whether adjuvant showed any impact on risk local recurrence and there were differences response between hereditary sporadic MTC. Methods A retrospective analysis involved 254 MTC patients, among them 73 patients with a disease. Two hundred twenty-four including 43 persons at high relapse, underwent only initial...
The role of radiotherapy in advanced medullary thyroid carcinoma (MTC) is confined to patients whom surgical treatment or the administration tyrosine kinase inhibitors are not possible contraindicated. High fractionated radiation doses during radiosurgery stereotactic applied reduce cancer-related symptoms and stabilize irradiated lesions. This study aimed retrospectively evaluate therapeutic effect MTC patients.The group involved 11 patients, treated due 16 cancer lesions, mainly bone...