A5010390049- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Diabetic Foot Ulcer Assessment and Management
- Infective Endocarditis Diagnosis and Management
- Pressure Ulcer Prevention and Management
- Bacterial Identification and Susceptibility Testing
- Drug-Induced Adverse Reactions
- Biosimilars and Bioanalytical Methods
- Wound Healing and Treatments
- Rheumatoid Arthritis Research and Therapies
- Muscle activation and electromyography studies
- Orthopedic Infections and Treatments
- Hematological disorders and diagnostics
- Vascular Procedures and Complications
- Neuroscience and Neural Engineering
- Spinal Fractures and Fixation Techniques
- Pharmacovigilance and Adverse Drug Reactions
- Intramuscular injections and effects
- Intracranial Aneurysms: Treatment and Complications
- Pharmaceutical Economics and Policy
- Antibiotics Pharmacokinetics and Efficacy
- Otolaryngology and Infectious Diseases
- Atrial Fibrillation Management and Outcomes
- Clinical Laboratory Practices and Quality Control
- EEG and Brain-Computer Interfaces
Loyola University Medical Center
2024
The Kids Research Institute Australia
2018-2023
The University of Western Australia
2018-2023
Royal Perth Hospital
2022-2023
Fiona Stanley Hospital
2019-2022
Tortuosity of the cavernous internal carotid artery (cICA) complicates neuro-endovascular access. Improved assessment cICA tortuosity could improve procedural outcomes. This study attempts to refine classification through analysis its effect on mechanical thrombectomy (MT) outcomes and externally validate previously scales. Retrospective single center review 191 patients who underwent transfemoral anterior circulation MT over 5 years. Four parameters were measured. Regression was performed...
Since 1955, the recommended strategy for rheumatic heart disease (RHD) secondary prophylaxis has been benzathine penicillin G [BPG; 1.2 MU (900 mg)] injections administered intramuscularly every 4 weeks. Due to dosing frequency, pain, and programmatic challenges, adherence is suboptimal. It previously demonstrated that BPG delivered subcutaneously at a standard dose safe tolerable favorable pharmacokinetics, setting scene improved regimens with less frequent administration. The safety,...
Benzathine penicillin G has been used as monthly deep intramuscular (IM) injections since the 1950s for secondary prevention of acute rheumatic fever and heart disease (RHD). Injection frequency pain are major programmatic barriers adherence, prompting calls development better long-acting preparations to prevent RHD. We hypothesized that subcutaneous (SC) administration benzathine could delay absorption when compared with IM injections.To compare pharmacokinetic profile tolerability...
Benzathine benzylpenicillin G (BPG) is recommended as secondary prophylaxis to prevent recurrence of acute rheumatic fever and subsequent heart disease (RHD). Following intramuscular injection, BPG hydrolysed benzylpenicillin. Little known the pharmacokinetics following in populations at risk RHD.We conducted a longitudinal pharmacokinetic study children adolescents receiving throughout six monthly cycles BPG. Dried blood spot samples were assayed with LC-MS/MS. Benzylpenicillin...
Objective Secondary prophylaxis through long-term antibiotic administration is essential to prevent the progression of acute rheumatic fever heart disease (RHD). Benzathine penicillin G (BPG) has been shown be most efficacious for this purpose; however, adverse events associated with BPG have anecdotally reported. This study therefore aimed collate case reports RHD prophylaxis. Study design A literature review was used explore reported reactions and inform development a report questionnaire....
Abstract Benzathine penicillin G (BPG) is used as first‐line treatment for most forms of syphilis and secondary prophylaxis against rheumatic heart disease (RHD). Perceptions that poor quality BPG linked to reported adverse effects therapeutic failure may impact RHD control programs. Clinical networks web‐based advertising were obtain vials from a wide range countries. The was assessed using high performance liquid chromatography assay capable detecting relevant impurities degradation...
Abstract Among 125 inpatients with diabetic foot infections managed by a multidisciplinary ulcer unit, knowledge of methicillin‐resistant Staphylococcus aureus colonisation status assisted decision‐making to prescribe appropriately or with‐hold empiric anti‐methicillin‐resistant therapy. Despite adherence national guidelines, apparent overuse anti‐pseudomonal therapy was frequent, providing potential antimicrobial stewardship opportunities.
Abstract Background Benzathine penicillin G (BPG) is the cornerstone of secondary prophylaxis to prevent Streptococcus pyogenes infections, which precede acute rheumatic fever (ARF). The paucity pharmacokinetic (PK) data from children and adolescents populations at highest risk ARF heart disease (RHD) poses a challenge for determining optimal dosing frequency injections undermines efforts develop improved regimens. Methods We conducted 6 month longitudinal PK study young people receiving BPG...
Trans-phalangeal and trans-metatarsal amputation, collectively termed 'minor amputations' are important procedures for managing infections of diabetes-related foot ulcers (DFU). Following minor international guidelines recommend a prolonged course antibiotics if residual infected bone on intra-operative samples identified, but the quality evidence underpinning these is low. In this study, we examined concordance microbiological results from proximal cultures compared to superficial wound...
Abstract BackgroundTrans-phalangeal and trans-metatarsal amputation, collectively termed ‘minor amputations’ are important procedures for managing infections of diabetes-related foot ulcers (DFU). Following minor international guidelines recommend a prolonged course antibiotics if residual infected bone on intra-operative samples identified, but the quality evidence underpinning these is low. In this study, we examined concordance microbiological results from proximal cultures compared to...