A5070347388- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Dermatological diseases and infestations
- Bacterial Identification and Susceptibility Testing
- Otolaryngology and Infectious Diseases
- Indigenous Health, Education, and Rights
- Dermatological and COVID-19 studies
- Zoonotic diseases and public health
- Injury Epidemiology and Prevention
- Climate Change and Health Impacts
- Indigenous Studies and Ecology
- Dermatology and Skin Diseases
- Musculoskeletal Disorders and Rehabilitation
- Agriculture and Farm Safety
- Rabies epidemiology and control
- Influenza Virus Research Studies
- Social Issues and Sustainability
- Acne and Rosacea Treatments and Effects
- Misinformation and Its Impacts
- Vector-borne infectious diseases
- Antibiotic Use and Resistance
- Qualitative Research Methods and Ethics
- Youth Development and Social Support
- Emergency and Acute Care Studies
The Kids Research Institute Australia
2019-2025
The University of Western Australia
2016-2025
Princess Margaret Hospital for Children
2024
The RHD Endgame Strategy: the blueprint to eliminate rheumatic heart disease in Australia by 2031 (the Strategy) is (RHD) 2031. Aboriginal and Torres Strait Islander people live with one of highest per capita burdens world. Strategy synthesises information compiled across 5-year lifespan End Rheumatic Heart Disease Centre Research Excellence (END CRE). Data results from priority research projects several disciplines complemented literature reviews, systematic reviews narrative reviews....
Insufficient and poorly maintained housing plumbing in many remote Australian Indigenous communities Australia results reduced capacity to maintain personal hygiene, contributing infectious disease inequalities. Infections from Streptococcus pyogenes (Strep A) sequalae are often noted be the result of contextual poverty; a product over 230 years discriminatory practice that has excluded people basic human rights healthy, afforded most nation. The solutions for eliminating diseases inequity...
<h3>Introduction</h3> The early years are a critical period in child9s health and development, yet most preschool children fail to meet physical activity guidelines. Outside of the home neighbourhood, spend large proportion time within childhood education care (ECEC) services such as long day care. Research is required determine how design outdoor (and indoor) spaces provides opportunities or constraints for activity. A significant evidence gap surrounds what objectively measured attributes...
Since 1955, the recommended strategy for rheumatic heart disease (RHD) secondary prophylaxis has been benzathine penicillin G [BPG; 1.2 MU (900 mg)] injections administered intramuscularly every 4 weeks. Due to dosing frequency, pain, and programmatic challenges, adherence is suboptimal. It previously demonstrated that BPG delivered subcutaneously at a standard dose safe tolerable favorable pharmacokinetics, setting scene improved regimens with less frequent administration. The safety,...
Background: Monthly intramuscular injections of benzathine penicillin G (BPG) remain the cornerstone secondary prophylaxis for acute rheumatic fever and heart disease (RHD). The barriers to successful delivery BPG may be patient- or service-delivery-dependent. Objective: aim present study was explore perceived acceptability implementation challenges treatment RHD, from perspective healthcare providers (HCPs). Methodology: A descriptive qualitative using semi-structured interview guides...
Reflexivity is crucial for researchers and health professionals working within Aboriginal health. provides a tool non-Aboriginal to contribute the broader intention of reframing historical academic positivist paradigms into Indigenous research methodologies (IRM) privilege voices in knowledge construction decision-making. This practice requires transition from safe familiar environments unfamiliar uncomfortable spaces. space often referred as 'third space'-the 'in-between' that can be...
The in-vivo plasma concentration of penicillin needed to prevent Streptococcus pyogenes pharyngitis, recurrent acute rheumatic fever, and progressive heart disease is not known. We used a human challenge model assess the minimum required streptococcal pharyngitis. In CHIPS, randomised, double-blind, placebo-controlled, trial, healthy adult volunteers were randomly assigned by computer-generated random sequence target steady-state concentrations (placebo, 3, 6, 9, 12, or 20 ng/mL). study was...
Background Four-weekly intramuscular (IM) benzathine penicillin G (BPG) injections to prevent acute rheumatic fever (ARF) progression have remained unchanged since 1955. A Phase-I trial in healthy volunteers demonstrated the safety and tolerability of high-dose subcutaneous infusions BPG which resulted a much longer effective exposure, fewer injections. Here we describe experiences young people living with ARF participating Phase-II S ub C utaneous I njections B P (SCIP). Methodology...
SummaryBackgroundHealthy skin is important for maintaining overall physical and cultural health wellbeing. However, remote-living Australian Aboriginal children contend with disproportionally high rates of Streptococcus pyogenes (Strep A) infected impetigo. The SToP Trial was a large stepped-wedge cluster randomised trial See, Treat, Prevent (SToP) activities implemented between 2019 2022 in the Kimberley region Western Australia, during which decrease impetigo observed. We aim to evaluate...
Secondary prophylaxis to prevent rheumatic heart disease (RHD) progression, in the form of four-weekly intramuscular benzathine benzylpenicillin G (BPG) injections, has remained unchanged since 1955. Qualitative investigations into patient preference have highlighted need for long-acting penicillins be delivered less frequently, ideally with reduced pain. We describe experience healthy volunteers participating a phase-I safety, tolerability and pharmacokinetic trial subcutaneous infusions...
Abstract Background Rheumatic heart disease (RHD) is a preventable yet deadly condition resulting from untreated Group A Streptococcus infection. Despite being eliminated most high-income countries, RHD and its precursor acute rheumatic fever (ARF) persist in developing countries settings of disadvantage. In Australia, Aboriginal Torres Strait Islander people experience among the world's highest rates. Following five years research, investigation advocacy, Endgame Strategy provides technical...
Abstract Background Leavers Festivals have become an institution for Australian youth to celebrate the completion of secondary school. Reported hazardous consumption alcohol by leavers has focused concern on risk‐taking behaviour. In response this, campaigns such as “Don't Drink and Drown” targeted reduce during aquatic activities. This research investigated intended actual consumption, particularly activities at a Festival located in coastal town Dunsborough, southern Western Australia....
Achieving healthy skin requires the prevention of infectious diseases that affect skin. Prevention activities range from environmental health improvements to address inequities in living situations, through community-wide treatment programs reduce transmission and improve health. In this paper we discuss pathogens cause conditions arise when is infected, burden disease northern Australia, some current research underway high burden, which predominantly affects remote-living Aboriginal Torres...
Introduction For millennia, Aboriginal people’s ways of knowing, doing and being were shared through art, song, dance. Colonisation silenced these ways, affecting loss self-determination for people. Over the past decade in Australia, hip-hop projects have become culturally appropriate approaches health promotion. When community led, worldviews centralised, workshops are more likely to be effective. In 2020, during COVID-19 pandemic, a community-led promotion music video, ‘HipHop2SToP’ was...
Regular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since 1950s. As pharmacological correlate protection remains unknown, it is difficult to recommend changes this established regimen. Determining minimum effective exposure required prevent
Background: Healthy skin is important for maintaining overall physical and cultural health wellbeing. However, remote-living Australian Aboriginal children contend with disproportionally high rates of Streptococcus pyogenes (Strep A) infected impetigo. The SToP Trial was a large stepped-wedge cluster randomised control trial 'See', 'Treat', 'Prevent' activities implemented between 2019 2022 in the Kimberley region Western Australia, during which decrease impetigo observed. We aim to evaluate...
Background: Skin infections affect physical and, through stigma, social-emotional health. When untreated, they can cause life-threatening conditions. We aimed to assess the effect of a holistic, co-designed, region-wide skin control program.Methods: The SToP Trial is pragmatic, cluster-randomised, stepped-wedge Trial, involving participants aged 0-18 years in nine remote communities Kimberley, Western Australia. involves programmatic interventions three domains: 'See' (skin checks, infection...