A5027310468- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Otolaryngology and Infectious Diseases
- Neonatal and Maternal Infections
- Adolescent Sexual and Reproductive Health
- Rabies epidemiology and control
- Bacterial Identification and Susceptibility Testing
- Dermatological diseases and infestations
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Cystic Fibrosis Research Advances
- Emergency and Acute Care Studies
- Hematological disorders and diagnostics
- Trauma and Emergency Care Studies
- Global Maternal and Child Health
- Cardiac Valve Diseases and Treatments
- Pneumonia and Respiratory Infections
- Clinical Reasoning and Diagnostic Skills
- Adolescent and Pediatric Healthcare
- Child and Adolescent Psychosocial and Emotional Development
- Vaccine Coverage and Hesitancy
- Phytoplasmas and Hemiptera pathogens
- Dermatology and Skin Diseases
- Hypothalamic control of reproductive hormones
The Kids Research Institute Australia
2016-2024
The University of Western Australia
2017-2024
Stanford University
2023
Princess Margaret Hospital for Children
2023
Perth Children's Hospital
2023
Harvard University
2021-2023
Harvard Global Health Institute
2022-2023
University Hospitals of Cleveland
2021
Case Western Reserve University
2021
KU Leuven
2019
Background In 2018, the World Health Organization prioritized control of acute rheumatic fever (ARF) and heart disease (RHD), including surveillance. We developed strategies for estimating contemporary ARF/RHD incidence prevalence in Australia (2015-2017) by age group, sex, region Indigenous non-Indigenous Australians based on innovative, direct methods. Methods Results This population-based study used linked administrative data from 5 Australian jurisdictions. A cohort ARF (age <45 years)...
Rheumatic heart disease (RHD) remains a of international importance, yet little has been published about progression in contemporary patient cohort. Multi-state models provide well-established method estimating rates transition between states, and can be used to evaluate the cost-effectiveness potential interventions. We aimed create multi-state model for RHD using serial clinical data from cohort Australian patients.
The RHD Endgame Strategy: the blueprint to eliminate rheumatic heart disease in Australia by 2031 (the Strategy) is (RHD) 2031. Aboriginal and Torres Strait Islander people live with one of highest per capita burdens world. Strategy synthesises information compiled across 5-year lifespan End Rheumatic Heart Disease Centre Research Excellence (END CRE). Data results from priority research projects several disciplines complemented literature reviews, systematic reviews narrative reviews....
Rheumatic heart disease (RHD) remains a leading cause of cardiovascular morbidity and mortality in children young adults disadvantaged populations. The emergence echocardiographic screening provides the opportunity for early detection intervention. Using our own multistate model RHD progression derived from Australian register data, we performed cost-utility analysis indigenous children, with dual aims informing policy decisions Australia providing that could be adapted other countries.
The World Health Organization published the preferred product characteristics for a Group A Streptococcus (Strep A) vaccine in 2018. Based on these parameters age of vaccination, efficacy, duration protection from vaccine-derived immunity, and vaccination coverage, we developed static cohort model to estimate projected health impact Strep at global, regional, national levels by country-income category. We used analyse six strategic scenarios. introduction between 2022 2034 primary scenario,...
BACKGROUND AND OBJECTIVES: Early first sexual intercourse (FSI) is a risk factor for unplanned teenage pregnancy, sexually transmitted infection, and adverse social, emotional, physical health outcomes in adolescence into adulthood. The aim of this study was to examine relationships between internalizing (eg, anxious/depressed, withdrawn) externalizing delinquent, aggressive) behavior problems childhood age at FSI. METHODS: We used large, population-based birth cohort (The Western Australian...
Invasive group A streptococcal (Strep A) infections occur when Streptococcus pyogenes, also known as beta-hemolytic Streptococcus, invades a normally sterile site in the body. This article provides guidelines for establishing surveillance invasive Strep infections. The primary objective of is to monitor trends rates infection and determine demographic clinical characteristics patients with laboratory-confirmed infection, age- sex-specific incidence population defined geographic area, risk...
Recent research has documented a wide range of health, economic, and social benefits conferred by vaccination, beyond the direct reductions in morbidity, mortality, future healthcare costs traditionally captured economic evaluations. In this paper, we describe societal that would likely stem from widespread administration safe effective vaccines against Streptococcus pyogenes (Strep A), which was estimated to be fifth-leading cause infectious disease deaths globally prior COVID-19 pandemic....
Acute rheumatic fever (ARF) and heart disease (RHD) persist as public health issues in developing countries among disadvantaged communities high-income countries, with rates Aboriginal Torres Strait Islander peoples Australia the highest recorded globally. A robust evidence base is critical to support policy recommendations for eliminating RHD, but available data are fragmented incomplete. The End RHD Australia: Study of Epidemiology (ERASE) Project aims provide a comprehensive database ARF...
ObjectivesIn preparation for the future arrival of a group A Streptococcus (GAS) vaccine, this study estimated economic and health burdens GAS diseases in New Zealand (NZ).MethodsThe annual incidence was based on extrapolation average number primary healthcare episodes managed each year general practices (2014–2016) hospitalizations occurring (2005–2014). Disease multiplied by cost diagnosing managing an episode disease at level care to estimate burden.ResultsGAS affected 1.5% population...
Rheumatic heart disease (RHD) is a major contributor to cardiac morbidity and mortality globally. This study aims estimate the probability predictors of progressing non-fatal cardiovascular complications death in young Australians after their first RHD diagnosis.This retrospective cohort used linked register, hospital, data from five Australian states territories (covering 70% whole population 86% Indigenous population). Progression uncomplicated all-cause (surgical intervention, failure,...
Younger age at menarche (AAM) may put girls risk for earlier first sexual intercourse (FSI). Young FSI has far-reaching negative outcomes. We describe the longitudinal relationship between AAM and in a large prospective birth cohort.AAM was collected from 554 Western Australia (Raine) Pregnancy Cohort Study, prospectively 10 or retrospectively 14. Age ages 17 20. Cox regression models likelihood of by years since younger (<12 years) older (≥14 relative to average (12-13 years).Girls with...
Adolescent and parent reports of adolescent mental health problems often correlate poorly, understanding this discrepancy has clinical importance. Yet contextual factors have only been inconsistently explained. At the 14- 17-year follow-ups Western Australian Pregnancy Cohort (Raine) Study, 1,596 parent-child dyads completed parent-reported Child Behaviour Checklist (CBCL) adolescent-rated Youth Self-Report (YSR). Maternal, family, adolescent, were examined as potential predictors...
Introduction Skin is important in Australian Aboriginal culture informing kinship and identity. In many remote communities, scabies impetigo are very common. Untreated skin infections painful, itchy frequently go untreated due to under-recognition lack of awareness their potential serious complications. We hypothesise that the infection burden communities can be reduced by implementing streamlined training treatment pathways integrated with environmental health promotion activities, tested...
Well publicised, rapid onset deaths in previously healthy children from invasive group A streptococcal disease (iGAS) Australia recent years have highlighted the emerging burden of iGAS.1-3 Here we explore evidence and knowledge gaps to inform clinicians, public health units Australian regarding iGAS definition epidemiological trends Australia. is associated with high morbidity, mortality substantial expenditure.4, 5 Clinical forms include sepsis, toxic shock syndrome, necrotising fasciitis,...
Group A Streptococcus causes a wide range of diseases from relatively mild infections including pharyngitis to more severe illnesses such as invasive and rheumatic heart disease (RHD). Our aim is estimate the cost-effectiveness hypothetical Strep vaccine on multiple manifestations at global-level. Cost-effectiveness analyses were carried out by building potential epidemiological impact vaccines that align with WHO's Preferred Product Characteristics for vaccines. Maximum vaccination costs...
Abstract The spectrum of diseases caused by Streptococcus pyogenes (Strep A) ranges from superficial to serious life-threatening invasive infections. We conducted a scoping review published articles between 1980 and 2021 synthesize evidence state transitions across the Strep A disease spectrum. identified 175 reporting 262 distinct observations transitions. Among included articles, transition an or toxin-mediated another (i.e., recurrent ARF, RHD death) was described 115 times (43.9% all...