A5056450018- Forensic Toxicology and Drug Analysis
- Hormonal and reproductive studies
- Ginseng Biological Effects and Applications
- Analytical Chemistry and Chromatography
- Pharmaceutical Quality and Counterfeiting
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Veterinary Pharmacology and Anesthesia
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Sensors
- Alcohol Consumption and Health Effects
- Phytochemicals and Antioxidant Activities
- Advanced Chemical Sensor Technologies
- Sexual function and dysfunction studies
- Natural product bioactivities and synthesis
- Hair Growth and Disorders
- Food Quality and Safety Studies
- Psychedelics and Drug Studies
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Synthesis and Biological Evaluation
- Anesthesia and Sedative Agents
- Insect and Pesticide Research
- Neurotransmitter Receptor Influence on Behavior
Kyungsung University
2015-2024
Kangbuk Samsung Hospital
2016
Sungkyunkwan University
2016
National Forensic Institute
2012
Seoul National University
2006-2008
To investigate whether or not the radical scavenging activity of ginseng is enhanced by heat processing, we evaluated effects white (WG), red (RG, steamed at 98—100 °C) and sun (SG, 120 on nitric oxide, superoxide (O2−), hydroxyl (·OH) radicals peroxynitrite (ONOO−). Heat-treated (RG SG) showed better O2−, ONOO− ·OH-scavenging activities than WG. In particular, SG were stronger those RG. Furthermore, maltol, salicylic acid, vanillic acid p-coumaric known as principal antioxidant components...
Betulin is a representative compound of Betula platyphylla, tree species belonging to the Betulaceae family. In this investigation, we revealed that betulin showed anticancer activity on human lung cancer A549 cells by inducing apoptosis and changes in protein expression profiles were observed. Upon flow cytometry analysis, surface betulin-treated was found be annexin-V positive propidium iodide (PI) negative, which indicated apoptotic. order identify molecular players involved...
Centipeda minima (L.) A. Braun & Asch is a well-studied plant in Chinese medicine that used for the treatment of several diseases. A recent study has revealed effects extract Cetipeda (CMX) standardized by brevilin inducing hair growth. However, mechanism action CMX human follicle dermal papilla cells (HFDPCs) not yet been identified. We aimed to investigate molecular basis underlying effect on growth HFDPCs. induced proliferation HFDPCs, and transcript-level expression Wnt family member...
Etomidate, with efficacy similar to that of propofol, has been used as a propofol substitute because is designated narcotic drug, and an increase in the frequency illegal distribution misuse reported Korea. Previous analytical studies on etomidate blood urine. For long-term use timing estimation, method for analysis using hair should be developed. Therefore, this study, LC-MS/MS was developed determine its major metabolite hair. Human samples were segmented after washing eliminate possible...
Hyperactivation of phosphoinositol 3-kinase (PI3K) has been suggested to be a potential mechanism for endoplasmic reticulum (ER) stress-enhanced airway hyperresponsiveness, and PI3K inhibitors have examined as asthma therapeutics. However, the regulatory linking ER stress related pathological signals in not defined. To elucidate these pathogenic pathways, we investigated influence selective PI3Kδ inhibitor, IC87114, on inflammation an ovalbumin/lipopolysaccharide (OVA/LPS)-induced model. In...
Two analogs of sildenafil and vardenafil in food were detected by column liquid chromatography (LC) with a photodiode array detector. They isolated preparative LC; their structures established mass spectrometry nuclear magnetic resonance spectrometry. One analog was found to be methisosildenafil (compound A), 5-(5-(3,5-dimethylpiperazin-1-ylsulfonyl)-2-ethoxy-phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]-pyrimidin-7(6H)-one. It is dimethylpiperazine ring substituted for the methylpiperazine...
Chronic neurodegenerative diseases are typically associated with oxidative stress conditions leading to neuronal cell death. We aimed investigate the neuroprotective effect of three pyranocoumarins (decursin, decursinol angelate, and decursinol) targeting factors. Decursin (also known as dehydro-8-prenylnaringenin) is a prenylated coumarin compound consisting ring system prenyl group attached one carbons in ring. As secondary metabolite plants, pyranocoumarin decursin from Angelica gigas...
Aim This study aimed to qualitatively identify the ranges of factors involved in tablet compression process for ivabradine Sustained Release (SR) tablets. Materials and Methods A full factorial design experiments was used three (pre- main-compression force paddle rotation time) SR For robust tableting, responses (content uniformity, friability, dissolution) were evaluated as critical quality attributes via analysis variance using Design Expert software. Results The main significantly...
Janus kinase 3 (JAK3) inhibitors have been used effectively in the treatment of several cases alopecia universalis and its variants. Our study aims to evaluate whether emulsion extract brevilin A from Centipeda minima (CMX) stimulates hair regrowth a clinical trial, as JAK3 inhibitor, combined with network pharmacology-based analysis. CMX showed potent inhibition concentration-dependent manner. Significant differences total count, terminal anagen count baseline 24 weeks were observed between...
Proteomics is a powerful tool to study molecular pathways and identify protein changes in cells. Anticancer drugs have been used proteomics evaluate pathways. Ginsenosides Rg5 Rk1 are key components of heat-processed ginseng, acknowledged for its anticancer properties causing apoptosis some cancer In this work, ginsenosides were applied lung cells the first time, proteins differentially affected by these treatment analyzed. Twenty-five specific from treated A549 compared After Rk1,...
Proteomics separates and analyzes proteins for investigation at the cellular level in regard to disease processing by analyzing proteins' expression, function, structure, post-translational modification, protein–protein interaction. In general forensic investigations, postmortem interval was evaluated measuring changes body temperature after death, along with entomological knowledge. These investigations may be restrictive subjective because of external factors. The objectives this study are...
A gas chromatography-mass spectrometry (GC-MS) method for the determination of propofol in human plasma has been developed and validated. Propofol was extracted from by using mixed-mode cation exchange/reversed-phase (MCX) cartridges. As easily volatilizes during concentration, 100% methanol injected directly into GC-MS to elute propofol. Despite avoiding concentration process eluted solution, lower limit quantization (LLOQ) 25 ng/mL. The validated exhibited good linearity (R (2) = 0.9989)...
버섯 내의 ergocalciferol, 즉 비타민 D의 함량을 증가시키기 위하여 많은 연구가 진행되고 있다. 본 연구의 목표는 자외선 조사를 통해 버섯을 선정하고 선정된 버섯의 ergocalciferol 함량이 증가한 제조 조건을 확립하여 제품개발 및 상업화를 위함이다. 연구에 사용된 새송이(Pleurotus eryngii), 느타리(Pleurotus ostreatus), 팽이(Flammulina velutipes), 양송이(Agaricus bisporus), 표고(Lentinula edodes) 5종의 대상으로 미세분말화한 후 조사에 따른 함량의 증진 효과를 조사하였다. 버섯은 30분 동안 크게 증가하였으며, 그중 표고버섯이 함량(76.12±2.53 μg/g)과 전환율(2.98%) 증진에 효과적이었다. 시간별 조사 시 표고버섯의 함량과 전환율이 높은 시간은 35.54 ±1.11 μg/g 5.56%로 15분이었다. 지역별 가장 지역은 함량 99.92±3.71 전환율...