A5044511006- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- COVID-19 epidemiological studies
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 diagnosis using AI
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- Anesthesia and Pain Management
- Electrolyte and hormonal disorders
- Venous Thromboembolism Diagnosis and Management
- Kawasaki Disease and Coronary Complications
- Opioid Use Disorder Treatment
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Biosensors and Analytical Detection
- Mental Health Treatment and Access
- Heparin-Induced Thrombocytopenia and Thrombosis
- IL-33, ST2, and ILC Pathways
Imperial College Healthcare NHS Trust
2020-2024
Imperial College London
2020-2021
St Mary's Hospital
2021
St Mary's Hospital
2021
St. Mary's Hospital
2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Intensive Care National Audit & Research Centre
2021
Abstract Background The prevalence and persistence of antibodies following a peak SARS-CoV-2 infection provides insights into its spread in the community, likelihood reinfection potential for some level population immunity. Methods Prevalence antibody positivity England, UK (REACT2) with three cross-sectional surveys between late June September 2020. 365104 adults used self-administered lateral flow immunoassay (LFIA) test IgG. A laboratory comparison LFIA results to neutralization activity...
Accurate antibody tests are essential to monitor the SARS-CoV-2 pandemic. Lateral flow immunoassays (LFIAs) can deliver testing at scale. However, reported performance varies, and sensitivity analyses have generally been conducted on serum from hospitalised patients. For use in community testing, evaluation of finger-prick self-tests, non-hospitalised individuals, is required.Sensitivity analysis was 276 participants. All had tested positive for by reverse transcription PCR were ≥21 days...
The time-concentrated nature of the first wave COVID-19 epidemic in England March and April 2020 provides a natural experiment to measure changes antibody positivity at population level before onset second initiation vaccination programme. Three cross-sectional national surveys with non-overlapping random samples undertaken between late June September (REACT-2 study). 365,104 adults completed questionnaires self-administered lateral flow immunoassay (LFIA) tests for IgG against SARS-CoV-2....
Emerging evidence suggests ethnic minorities are disproportionately affected by coronavirus disease 2019 (COVID-19). Detailed clinical analyses of multicultural hospitalized patient cohorts remain largely undescribed. We performed regression, survival, and cumulative competing risk to evaluate factors associated with mortality in patients admitted for COVID-19 3 large London hospitals between 25 February 5 April, censored as 1 May 2020. Of 614 (median age, 69 [interquartile range, 25] years)...
To evaluate the performance of new lateral flow immunoassays (LFIAs) suitable for use in a national coronavirus disease 2019 (covid-19) seroprevalence programme (real time assessment community transmission 2-React 2). Diagnostic accuracy study. Laboratory analyses were performed United Kingdom at Imperial College, London and university facilities London. Research clinics finger prick sampling run two affiliated NHS trusts. Sensitivity on sera stored from 320 previous participants React 2...
Background & aims Although metabolic risk factors are associated with more severe COVID-19, there is little evidence on outcomes in patients non-alcoholic fatty liver disease (NAFLD). We here describe the clinical characteristics and of NAFLD a cohort hospitalised for COVID-19. Methods This study included all consecutive admitted COVID-19 between February April 2020 at Imperial College Healthcare NHS Trust, either imaging available dated within one year from admission or known diagnosis...
Abstract Background England has experienced high rates of SARS-CoV-2 infection during the COVID-19 pandemic, affecting in particular minority ethnic groups and more deprived communities. A vaccination programme began December 2020, with priority given to administering first dose largest number older individuals, healthcare care home workers. Methods cross-sectional community survey undertaken between 26 January 8 February 2021 as fifth round REal-time Assessment Community Transmission-2...
Psoriatic arthritis (PA) may respond to disease-modifying antirheumatic therapy. The value of assessing disease activity with indices devised for rheumatoid (RA) was investigated in 72 patients seronegative PA. Thirty had a peripheral polyarthritis including the distal interphalangeal joints (DIPJs) and 15 symmetrical sparing DIPJs (RA-like). Significant correlations (Spearman rank test) were seen between clinical variables (pain score, grip strength, Ritchie articular index summated...
Abstract Patients with strong clinical features of COVID-19 negative real time polymerase chain reaction (RT-PCR) SARS-CoV-2 testing are not currently included in official statistics. The scale, characteristics and relevance this group well described. We performed a retrospective cohort study two large London hospitals to characterize the demographic, clinical, hospitalization outcome swab-negative patients. found 1 5 patients swab suspicion received diagnosis within documentation, discharge...
Abstract Introduction The upwards trend in opioid prescribing poses concern for older adults given risks associated with prolonged use.[1] With patients 65 years or being predominantly prescribed stronger opioids, minimising duration of therapy is important to reduce falls, fracture and hospitalisation risk.[2] Studies assessing the associations between initial prescription attributes use have yet be conducted an Irish setting. Aim This study aims assess long-term opioid-naive initiated on...
Abstract Introduction Osteoarthritis is a chronic, progressive joint disease, associated with frequent pain, and functional decline. The primary risk factor for developing osteoarthritis advanced age. Older patients are more susceptible to the adverse effects of commonly prescribed analgesics such as opioids non-steroidal anti-inflammatory drugs (NSAIDs), owing greater prevalence comorbidities age-related changes in this cohort. analgesic burden prescribing trends cohort largely unknown...
Abstract Patients with strong clinical features of COVID-19 negative real time polymerase chain reaction (RT-PCR) SARS-CoV-2 testing are not currently included in official statistics. The scale, characteristics and relevance this group thus unknown. We performed a retrospective cohort study two large London hospitals to characterize the demographic, clinical, hospitalization outcome swab-negative patients. found 1 5 patients swab suspicion received diagnosis within documentation, discharge...
Despite increasing use of in vitro models that closely resemble vivo human biology, their application understanding downstream effects airway toxicity, such as inflammation, are at an early stage. In this study, we used various assays to examine the inflammatory response induced MucilAirTM tissues and A549 cells exposed three products known induce toxicity. Reduced barrier integrity was observed following exposure each product, with reduced viability increased cytotoxicity also shown....
You have accessJournal of UrologyCME1 Apr 2023MP15-01 THE NEW PANDEMIC: MONKEYPOX AND ITS UROLOGICAL PRESENTATIONS Alex Murray, Piotr Śluzar, Anna Daunt, Aatish Patel, Nori Achyuta, Geraldine O'Hara, and Tet Yap MurrayAlex Murray More articles by this author , ŚluzarPiotr Śluzar DauntAnna Daunt PatelAatish Patel AchyutaNori Achyuta O'HaraGeraldine O'Hara YapTet View All Author Informationhttps://doi.org/10.1097/JU.0000000000003235.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack...
You have accessJournal of UrologyCME1 Apr 2023MP15-03 MONKEYPOX AND THE PENIS: AN EMPIRICAL CARE PATHWAY Piotr Sluzar, Alex Murray, Anna Daunt, Aatish Patel, Achyuta Nori, Geraldine O'Hara, and Tet Yap SluzarPiotr Sluzar More articles by this author , MurrayAlex Murray DauntAnna Daunt PatelAatish Patel NoriAchyuta Nori O'HaraGeraldine O'Hara YapTet View All Author Informationhttps://doi.org/10.1097/JU.0000000000003235.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)