A5026812653- Parasitic Infections and Diagnostics
- Toxoplasma gondii Research Studies
- Coccidia and coccidiosis research
- Neuropeptides and Animal Physiology
- Amoebic Infections and Treatments
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Redox biology and oxidative stress
- Signaling Pathways in Disease
- Viral Infections and Immunology Research
- Infective Endocarditis Diagnosis and Management
- Clostridium difficile and Clostridium perfringens research
- Parasites and Host Interactions
- Heat shock proteins research
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2024
Infectiologie Animale et Santé Publique
2018-2024
Université de Tours
2019
Wellcome Centre for Molecular Parasitology
2018-2019
Centre Val de Loire
2019
University of Glasgow
2019
Targeting parasitic endonuclease CPSF3 with an oxaborole offers a potent and selective candidate treatment against cryptosporidiosis.
Apicomplexan parasites are global killers, being the causative agents of diseases like toxoplasmosis and malaria. These known to be hypersensitive redox imbalance, yet little is understood about cellular roles their various regulators. The apicoplast, an essential plastid organelle, a verified apicomplexan drug target. Nuclear-encoded apicoplast proteins traffic through ER multiple sub-compartments place function. We propose that thioredoxins contribute control protein trafficking function...
Summary Apicomplexan parasites cause diseases such as malaria and toxoplasmosis. The apicomplexan mitochondrion shows striking differences from common model organisms, including fundamental processes mitochondrial translation. Despite evidence that translation is essential for parasite survival, it largely understudied. Progress has been restricted by the absence of functional assays to detect translation, a lack knowledge proteins involved in process inability identify mitoribosomes. We...
Coccidia are obligate intracellular protozoan parasites responsible for human and veterinary diseases. Eimeria tenella, the aetiologic agent of caecal coccidiosis, is a major pathogen chickens. In Toxoplasma gondii, some kinases from rhoptry compartment (ROP) key virulence factors. ROP hijack modulate many cellular functions pathways, allowing T. gondii survival development. E. tenella's kinome comprises 28 putative members kinase family; most them predicted, as pseudokinases their have...
ABSTRACT Background Human cryptosporidiosis is distributed worldwide, and it recognised as a leading cause of acute diarrhoea death in infants low- middle-income countries. Besides immune status, the higher incidence severity this gastrointestinal disease young children could also be attributed to digestive environment. For instance, human physiology undergoes significant changes with age, however role variability plays Cryptosporidium parvum pathogenesis not known. In study, we analysed for...
Summary Apicomplexan parasites cause diseases such as malaria and toxoplasmosis. The apicomplexan mitochondrion shows striking differences from common model organisms, including in fundamental processes mitochondrial translation. Despite evidence that translation is essential for survival, it largely understudied. Progress has been restricted by the absence of functional assays to detect translation, a lack knowledge proteins involved process inability identify mitoribosomes. Using mRNA...