Chagas disease, caused by the parasite Trypanosoma cruzi, affects millions of people in South America. The current treatments are limited, have severe side effects, and only partially effective. Drug repositioning, defined as finding new indications for already approved drugs, has potential to provide therapeutic options Chagas. In this work, we conducted a structure-based drug repositioning approach with over 130,000 3D protein structures identify drugs that bind targets thus represent...

Theory predicts that parasites can affect and thus drive their hosts' niche. Testing this prediction is key, especially for vector-borne diseases including Chagas disease. Here, we examined the niche use of seven triatomine species occur in Mexico, based on whether they are infected or not with Trypanosoma cruzi, vectors causative disease, respectively. Presence data triatomines (Triatoma barberi, T. dimidiata, longipennis, mazzottii, pallidipennis, phyllosoma picturata) were used divided...

Background: Chagas disease, a zoonosis transmitted mainly by hematophagous insects of the subfamily Triatominae, is caused Trypanosoma cruzi, classified into six discrete typing units (DTUs: TcI-TcVI and Tcbat). Methods: Insect vectors were collected from 84 human dwellings in municipality Santo Domingo Tehuantepec, Oaxaca, Mexico; 4.76% infested. DTUs determined using conventional nested PCR. Results: The infection rate was 43.6%. All infected with TcI while one specimen showed mixed TcII....

Triatomine insects are vectors of Trypanosoma cruzi, the causal agent Chagas disease. The insect-parasite interaction has been studied in relation to transmission and prevalence this For most triatomines, however, several crucial aspects insect immune response still unknown. example, only for Rhodnius prolixus Triatoma infestans activity phenoloxidase (PO) its zymogen prophenoloxidase (proPO) reported hemolymph anterior midgut (AM). aim study was gain insight into T. cruzi infection an...

Abstract Little is known about how the virulence of a human pathogen varies in environment it shares with its vector. This study focused on whether Trypanosoma cruzi (Trypanosomatida: Trypanosomatidae), causal agent Chagas' disease, related to altitude. Accordingly, Triatoma dimidiata (Hemiptera: Reduviidae) specimens were collected at three different altitudes (300, 700 and 1400 m a.s.l.) Chiapas, Mexico. The parasite was then isolated infect uninfected T. from same altitudes, as well...

Infection by the nematode Enterobius vermicularis (Enterobiasis) is most common helminth parasitosis in humans. It closely related to poverty, and a higher prevalence observed children, those who can cause important complications. Due this, we evaluated of Enterobiasis children from marginalized community southeastern Mexico. Additionally, analyzed possible cases ectopic infection girls presence coinfections with other pathogens. Of 904 found 21%, being than boys. determined E. vagina 11 had...

A wide variety of mammals are involved in the sylvatic cycle Trypanosomacruzi, causative agent Chagas disease. In many areas Latin America where T.cruzi is endemic, this poorly known, and its main reservoirs have not been identified. study we analyzed infection bats other small from an Ecological Reserve southeastern Mexico. From January through March 2021, captured wild individuals to extract cardiac peripheral blood, was detected by PCR mini-exon gene. bats, prevalence 16.36%, while...

En 1909, Carlos Justiniano Chagas describió por primera vez las manifestaciones clínicas de la enfermedad Chagas. El parásito hemoflagelado Trypanosoma cruzi (agente) se caracteriza presencia un flagelo, y en su citoplasma presenta organelos como el citostoma, los glicosomas, reservosomas núcleo. ciclo vida T. inicia cuando vector defeca sobre piel del hospedero sus heces contienen tripomastigotes metacíclicos, que infectan células vertebrado. Los vectores esta pertenecen a Subfamilia...

Abstract Background Relatively little is known about how pathogens transmitted by vector insects are affected changing temperatures analogous to those occurring in the present global warming scenario. One expectation that, like their ectothermic vectors, an increase temperature could reduce fitness. Here, we have investigated effect of high on abundance Trypanosoma cruzi parasites during infection Triatoma pallidipennis . Methods We exposed T. nymphs two strains (Morelos and Chilpancingo)...

RESUMENIntroducción. El parásito Trypanosoma cruzi es el agente etiológico de la enfermedad Chagas. Su transmisión a través insectos subfamilia Triatominae, donde Triatoma dimidiata uno los vectores principales en México y Centro América. La del depende factores como tasa infección las distintas especies tiempo defecación después alimentación. Objetivo. Evaluar con T. cinco estadios determinar postprandial. Material métodos. Treinta individuos cada estadio fueron alimentados sangre infectada...

Ecoepidemiology is an emerging field that attempts to explain how biotic, environmental, and even social factors influence the dynamics of infectious diseases. Particularly in vector-borne diseases, study under this approach offers us overview pathogens, vectors, hosts coexist a given region their ecological determinants. As result this, risk predictions can be established changing environment it may impact human populations. This paper aimed at evaluating some ecoepidemiological...

Parasitic diseases, predominantly prevalent in developing countries, are increasingly spreading to high-income nations due shifting migration patterns. The World Health Organization (WHO) estimates approximately 300 million annual cases of giardiasis. emergence drug resistance and associated side effects necessitates urgent research address this growing health concern. In study, we evaluated over eleven thousand pharmacological compounds sourced from the FDA database assess their impact on...

Triatomine bugs carry the parasitic protozoa Trypanosoma cruzi, causal agent of Chagas disease. It is known that both parasite and entomopathogenic fungi can decrease bug survival, but combined effect pathogens not known, which relevant for biological control purposes. Herein, survival triatomine Meccus pallidipennis (Stal, 1872) was compared when it coinfected with fungus Metarhizium anisopliae (Metschnikoff) T. acted separately. The immune response insect also studied, using phenoloxidase...

Background: Triatomine bugs are natural vectors of Trypanosoma cruzi, which causes Chagas disease or American trypanosomiasis. The role sylvatic triatomine species as T. cruzi in Mexico remains to be fully understood. Our research on the epidemiology Southeastern involved sampling triatomines rural settings. Materials and Methods: A was collected a peridomestic environment dwelling state Chiapas. identified morphologically an adult female Eratyrus cuspidatus Stal. Results: Microscopic...

Background: The Trypanosoma cruzi parasite is the causal agent of Chagas disease, recognized by World Health Organization as a neglected tropical disease. Currently there are seven discrete typing units (DTUs) T. distributed in America, but still gaps about its distribution some endemic regions. Materials and Methods: Seventeen isolated from Chiapas Oaxaca Mexico were identified amplification C-5 sterol desaturase gene. Results: Three DTUs cruzi, TcI (6), TcII (10), TcIV (1) detected...

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Introducción. El 30 de enero 2020, la OMS declaró emergencia sanitaria por aparición un nuevo coronavirus: SARS-CoV-2, que provoca enfermedad COVID-19. En las primeras fases una pandemia, adoptar conductas precaución es crucial para prevenir rápida propagación enfermedad. Objetivo. Analizar percepciones riesgo, emociones y comportamientos jóvenes estudiantes residentes regiones rurales e indígenas gran marginación Chiapas, México, sobre el Metódos. Se aplicó encuesta a del Colegio...