A5033746969- Insect Utilization and Effects
- RNA and protein synthesis mechanisms
- Insect and Arachnid Ecology and Behavior
- Mechanisms of cancer metastasis
- Animal and Plant Science Education
- DNA Repair Mechanisms
- Calpain Protease Function and Regulation
- Retinal Development and Disorders
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Ubiquitin and proteasome pathways
- Toxoplasma gondii Research Studies
- PARP inhibition in cancer therapy
- Metabolism, Diabetes, and Cancer
- Glycosylation and Glycoproteins Research
South China Agricultural University
2024
University of Nebraska Medical Center
2014-2019
Hunan Normal University
2013-2014
The mammalian small ubiquitin-like modifiers (SUMOs) are actively involved in regulating differentiation of different cell types. However, the functional differences between SUMO isoforms and their mechanisms action remain largely unknown. Using ocular lens as a model system, we demonstrate that SUMOs display distinct functions epithelial cells into fiber cells. During differentiation, SUMO1 SUMO2/3 displayed expression, localization, targets, suggesting differential functions. Indeed,...
BRCA1 C-terminal domains are found in a specialized group of 23 proteins that function the DNA damage response to protect genomic integrity. domain phosphatase 1 (CTDP1) is only with human proteome, yet direct participation has not been reported. Examination CTDP1 domain-specific protein interaction network revealed 103 high confidence interactions enriched proteins, including FANCA and FANCI central Fanconi anemia repair pathway necessary for resolution interstrand crosslink damage....
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction FA pancreas β cells is unknown. Therefore, we sought evaluate functional role FANCA, most commonly mutated gene in FA, glucose-stimulated insulin secretion (GSIS). This study reveals that FANCA FANCB knockdown impairs GSIS human cell line EndoC-βH3. To identify potential pathways by which...
The extracellular signal-regulated kinase (ERK) is one of the three major types mitogen-activated protein kinases. Previous studies showed that ERKs mediate various signaling pathways for cell proliferation, differentiation, survival and transformation in mammals. In present study, we use goldfish as a model system demonstrate ERK kinases play important roles promoting embryonic regulate development eye trunk vertebrates. are highly expressed multiple tissues including lens epithelial cells,...
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