A5082402657- Plasmonic and Surface Plasmon Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Advanced Fiber Optic Sensors
- Photonic and Optical Devices
- Optical Coatings and Gratings
- Biosensors and Analytical Detection
- Analytical Chemistry and Sensors
- RNA modifications and cancer
- Metamaterials and Metasurfaces Applications
- Gas Sensing Nanomaterials and Sensors
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Spectroscopy and Laser Applications
- Advanced Fiber Laser Technologies
- Cancer-related molecular mechanisms research
- Photonic Crystal and Fiber Optics
- Nanomaterials and Printing Technologies
- Tracheal and airway disorders
- RNA Research and Splicing
- Polydiacetylene-based materials and applications
- Polymer Surface Interaction Studies
- Protein Interaction Studies and Fluorescence Analysis
- Nonlinear Optical Materials Studies
- RNA Interference and Gene Delivery
Dalian University of Technology
2015-2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Harbin Medical University
2023-2024
Third Affiliated Hospital of Harbin Medical University
2023-2024
Arizona State University
2023
Vertex Pharmaceuticals (United States)
2023
Harbin Normal University
2022-2023
Liaocheng University
2023
Rationale: Elexacaftor/tezacaftor/ivacaftor has been shown to be safe and effective in people with cystic fibrosis (CF) aged ≥6 years ≥1 F508del-CFTR allele but not studied younger children. Objectives: To evaluate the safety, pharmacokinetics, pharmacodynamics, efficacy of elexacaftor/tezacaftor/ivacaftor children CF 2 through 5 years. Methods: In this Phase 3, open-label, two-part study (Parts A B), weighing <14 kg (on Day 1) received elexacaftor 80 mg once daily, tezacaftor 40 ivacaftor...
Dense arrays of well-dispersed gold nanoparticles (AuNPs) on optical fibers are shown to bridge the gap in sensitivity and sensing performance between localized surface plasmon resonance (LSPR) classical SPR sensing. A simple self-assembly method relying a poly(styrene- b-4-vinylpyridine) (PS- b-P4VP) block copolymer brush layer was used immobilize AuNPs different diameters from 10 92 nm fibers. In comparison with standard AuNP deposition methods using (3-aminopropyl)trimethoxysilane (APTMS)...
A 24-week, phase 3, open-label study showed elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was safe and efficacious in children aged 6-11 years with cystic fibrosis (CF) one or more
Abstract Localized surface plasmon resonance (LSPR) biosensors, which enable nanoscale confinement and manipulation of light, offer the enhanced sensitivity electromagnetic energy localization. The integration LSPR with fiber-optic technology has led to development compact versatile sensors for miniaturization remote sensing. This comprehensive review explores various sensor configurations, fiber types, geometric shapes, highlighting their benefits in terms sensitivity, integration,...
A novel surface plasmon resonance (SPR) thermometer based on liquid crystal (LC) filled hollow fiber is demonstrated in this paper. was internally coated with silver and then LC. The SPR response to temperature studied using modeling verified experimentally. results that the refractive index of LC decreases increasing variation can be detected by wavelength shift resonance. sensitivities were 4.72 nm/°C range 20 34.5 °C 0.55 36 50 °C, At phase transition between nematic isotropic phases LC,...
We present a novel multilayer-coated surface plasmon resonance sensor for dual refractive index range measurements based on capillary structure. The sensing elements include an internally coated Ag layer and externally bilayer of Au with overlayer thin indium tin oxide (ITO). internal was sensitive to higher (RI) medium while the external Au/ITO lower medium. evaluated performance by measuring RI changes in two channels, sensitivities were -1951 nm/RIU 2496 nm/RIU, respectively. This...
In this article, a tilted fiber Bragg grating (TFBG) plasmonic sensor based on thymine (T) - Hg (T-Hg-T) base asymmetric pairing and Au nanoparticles (AuNPs), which can be used for highly sensitive selective ultra-low-concentration <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> detection, has been demonstrated. As is known, TFBG provide an effective mean to easily excite the surface plasmon resonance (SPR) phenomenon while coated with...
Oesophageal squamous cell carcinoma (ESCC) is a lethal malignancy. Immune checkpoint inhibitors (ICIs) showed great clinical benefits for patients with ESCC. We aimed to construct model predicting prognosis and response ICIs by integrating diverse programmed death (PCD) forms.
This study aimed to reveal the interactions and coordination between culture, ecology, tourism. Using Jiangsu, Zhejiang, Shanghai, Anhui (JZSA1) region of China as area, we constructed an eco-cultural tourism system evaluation index system, calculated coupling degree (CCD2) using coupled model, identified influencing factors obstacle model. The findings show that CCD JZSA continuously improved from 2009 2019 reached intermediate level in 2019. However, there was still obvious regional...
We previously reported lncRNA HAR1A as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the delicate working mechanisms of this remain obscure. Herein, we demonstrated that ectopic expression inhibited proliferation, epithelial-mesenchymal transition (EMT), migration, and invasion NSCLC cells enhanced paclitaxel (PTX) sensitivity vitro vivo. identified oncogenic protein annexin 2 (ANXA2) potential interacting patterner HAR1A. overexpression ANXA2 ubiquitination accelerated...
Well-dispersed and dense layers of gold nanorods (AuNRs) on optical fibers are shown to regulate the longitudinal peak wavelength enhance sensing performances localized surface plasmon resonance (LSPR) biosensors. A simple self-assembly method relying a brush-like monolayer poly(styrene)-b-poly(acrylic acid) (PS-b-PAA) diblock copolymer was used immobilize AuNRs with various aspect ratios from 2.33 4.60 fibers. Both experimental simulation results illustrated that particle ratio, deposition...
Abstract Biomolecular detection at a low concentration is usually the most important criterion for biological measurement and early stage disease diagnosis. In this paper, highly sensitive nanoplasmonic biosensing approach demonstrated by achieving near‐infrared plasmonic excitation on continuous gold‐coated nanotriangular array. Near‐infrared incident light small angle excites surface plasmon resonance with much higher spectral sensitivity compared traditional configuration, due to its...
A metallic nanoring array supports two plasmonic modes with a complementary sensing scheme for detecting broad range of biomolecules.
To overcome low surface coverage and aggregation of particles, which usually restricts the sensitivity resolution conventional localized plasmon resonance (LSPR) fiber-optic sensors, we propose a simple self-assembled templating technique that uses nanometer thickness block copolymer (BCP) layer poly(styrene-b-4-vinylpyridine) to form 33 nm gold nanoparticle (AuNP) monolayer with high uniformity density for LSPR sensing. The wavelength this PS-b-P4VP templated methodology is 592 its...
A high performance humidity sensor using tilted fiber Bragg grating (TFBG) and functional graphene oxide (GO)/multi-walled carbon nanotubes (MWCNTs) hybrid nano-materials was proposed. The humidity-sensitive material with three-dimensional (3D) structure synthesized by the MWCNTs GOs. Comparing traditional two dimensional (2D) GOs film, water molecules could be absorbed effectively due to larger ripples more holes in GO/MWCNTs layers. molecule will fill entire space 3D instead of air, which...
Herein, we report the simultaneously application of surface plasmon resonance (SPR) spectroscopy and electrochemistry (EC) technology for real-time quantitative investigation heavy metal ions, with high selectivity sensitivity. A optical fiber coated over nanometric gold film then modified a dithiol self-assembled monolayer 1,6-hexanedithiol (HDT) was developed as dual mode electrochemical-surface (EC-SPR) sensor. The limit detection proposed sensor exposed in Hg <sup...
A sandwich type titled fiber Bragg grating (TFBG) plasmonic sensor based on self-assembled p-mercaptophenylboronic acid (PMBA) monolayer and Au nanoparticles (AuNPs), has been demonstrated successfully applied for sensitive stable low-concentration glucose detection. The was immobilized with PMBA acting as the highly recognition molecule instead of a traditional unstable enzyme. In experiments, high sensitivity detection is achieved, establishing competitive limit (LOD) 295 pM large dynamic...
Localized surface plasmon resonance (LSPR) and lossy mode (LMR) are excited simultaneously by the gold nanoparticle (AuNP) arrays top-coated polyelectrolyte layer on optical fibers. The well-dispersed dense AuNP ordered diblock copolymer-template have LSPR sensing characteristics, whereas layer-by-layer coated film carries LMR-based sensitivity enhancement. Both experimental simulation results illustrated that thickness of is key factor affecting properties proposed polyelectrolyte-enhanced...
Abstract The capacity to identify small amounts of pathogens in real samples is extremely useful. Herein, we proposed a sensitive platform for detecting using cyclic DNA nanostructure@AuNP tags (CDNA) and cascade primer exchange reaction (cPER). This employs wheat germ agglutinin-modified Fe 3 O 4 @Au magnetic nanoparticles (WMRs) bind the E. coli O157:H7, then triggers cPER generate branched products CDNA tag hybridization with high stability amplified SERS signals. It can target as low...