A5021935819- Oral microbiology and periodontitis research
- Gut microbiota and health
- Salivary Gland Disorders and Functions
- Liver Disease Diagnosis and Treatment
- Infant Nutrition and Health
- Preterm Birth and Chorioamnionitis
- Antimicrobial Peptides and Activities
- Oral and gingival health research
- dental development and anomalies
- S100 Proteins and Annexins
- Bone and Dental Protein Studies
Tokyo Medical and Dental University
2016-2019
The University of Tokyo
2017-2018
Abstract Increasing evidence indicates that periodontitis affects non-alcoholic fatty liver disease (NAFLD). We examined the relationship between periodontal bacterial infection and clinical/biochemical parameters in 52 NAFLD patients. Anti- Aggregatibacter actinomycetemcomitans ( Aa ) antibody titers correlated positively with visceral fat, fasting plasma insulin, HOMA-IR; negatively liver/spleen ratio. C57BL/6J mice (8-weeks-old) were given or saline (control) for 6 weeks, fed either...
Many risk factors related to the development of non-alcoholic fatty liver disease (NAFLD) have been proposed, including most well-known diabetes and obesity as well periodontitis. As periodontal pathogenic bacteria produce endotoxins, treatment can result in endotoxemia. The aim this study was investigate effects intravenous, sonicated Porphyromonas gingivalis (Pg) injection on glucose/lipid metabolism, steatosis, gut microbiota mice. Endotoxemia induced C57BL/6J mice (8 weeks old) by...
Increasing evidence suggests that periodontitis can exacerbate diabetes, and gut bacterial dysbiosis appears to be linked with the diabetic condition. The present study examined effects of oral administration periodontopathic bacterium, Porphyromonas gingivalis, on microbiota systemic conditions in streptozotocin-induced mice.Diabetes was induced by streptozotocin injection C57BL/6J male mice (STZ). STZ wild-type (WT) were orally administered P. gingivalis (STZPg, WTPg) or saline (STZco,...
Background and Objective Periodontal disease is a chronic infectious that results in bone loss. Many epidemiological studies have reported the progression of periodontal tissue destruction patients with diabetes; however, associated mechanism remains unclear. In this study, we comprehensively investigated how diabetes affects alveolar loss using ligature‐induced periodontitis model streptozotocin‐induced diabetic (STZ) mice. Material Methods Diabetes was induced by intraperitoneal injection...
Periodontitis is an inflammatory disease caused by pathogenic oral microorganisms that induce the destruction of periodontal tissue. We sought to identify relevant differentially expressed genes (DEGs) and clarify mechanism underlying rapid alveolar bone loss using ligature-induced periodontitis in mice. A silk ligature was tied around maxillary left second molar 9-week-old C57BL/6 J male In-vivo micro-CT analysis revealed ligation induced severe loss. RNA-sequencing analysis, examine host...
Growing evidence indicates an association between periodontitis and delivery outcome; however, the mechanism is unclear. This study aimed to investigate influence of Porphyromonas gingivalis (Pg) infection on outcome in mice.Bacteremia was induced pregnant Slc:ICR mice (8 weeks old) by intravenous injection Pg. Mice were randomly divided into a control group (CO), those receiving Pg at gestational day 1 (GD1), 15 (GD15) or every (ED). Delivery outcome, infection, gene expression placenta...