A5083526006- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- RNA regulation and disease
- Congenital heart defects research
- Congenital Heart Disease Studies
- RNA Research and Splicing
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Coronary Artery Anomalies
- Sleep and Wakefulness Research
Max Planck Florida Institute for Neuroscience
2017-2024
University of Cambridge
2014
Neurocentre Magendie
2012-2014
Université de Bordeaux
2014
Inserm
2012-2014
The cerebellar system helps modulate and fine-tune motor action. Purkinje cells (PCs) provide the sole output of cortex, therefore, any involvement in activity must be driven by changes PC firing rates. Several different cell types influence including excitatory input from parallel fibers inhibition molecular layer interneurons (MLIs). Similar to PCs, MLI is fibers, MLIs feed-forward onto PCs. To aid experimental assessment how contributes function behavior, we characterized a new knock-in...
Abstract The signals in cerebellar Purkinje cells sufficient to instruct motor learning have not been systematically determined. Therefore, we applied optogenetics mice autonomously excite and measured the effect of this activity on plasticity induction adaptive behavior. Ex vivo, excitation channelrhodopsin-2-expressing elicits dendritic Ca 2+ transients with high-intensity stimuli initiating spiking that additionally contributes response. Channelrhodopsin-2-evoked potentiate co-active...
Procedural memories formed in the cerebellum response to motor errors depend on changes Purkinje cell (PC) spiking patterns that correct movement when erroneous context is repeated. Because molecular layer interneurons (MLIs) inhibit PCs, learning-induced MLI output may participate reshaping PC patterns. However, it remains unclear whether error-driven learning alters activity and such are necessary for memory engram. We addressed this knowledge gap by measuring manipulating flocculus of...
Abstract Neurodevelopmental disorders are thought to arise from intrinsic brain abnormalities. Alternatively, they may disrupted crosstalk among tissues. Here we show the local reduction of two vestibulo-cerebellar lobules, paraflocculus and flocculus, in mouse models humans with 22q11.2 deletion syndrome (22q11DS). In mice, this paraflocculus/flocculus dysplasia is associated haploinsufficiency Tbx1 gene. also leads impaired cerebellar synaptic plasticity motor learning. However, neural...
Abstract Procedural memories formed in the cerebellum response to motor errors depend on changes Purkinje cell (PC) spiking patterns that correct movement when erroneous context is repeated. Because molecular layer interneurons (MLIs) inhibit PCs, learning-induced MLI output may participate reshaping PC patterns. Yet, it remains unclear whether error-driven learning alters activity and such are necessary for memory engram. We addressed this knowledge gap by measuring manipulating flocculus...