Saverio Continisio

ORCID: 0000-0001-6595-9990
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About
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Research Areas
  • Cardiac Valve Diseases and Treatments
  • Aortic Disease and Treatment Approaches
  • Infective Endocarditis Diagnosis and Management
  • Cardiac Imaging and Diagnostics
  • Cardiovascular Issues in Pregnancy
  • Cardiac Arrhythmias and Treatments
  • Cardiovascular Function and Risk Factors
  • Cardiac Structural Anomalies and Repair
  • Coronary Interventions and Diagnostics
  • COVID-19 Clinical Research Studies
  • Coronary Artery Anomalies
  • Cardiovascular Disease and Adiposity
  • Atrial Fibrillation Management and Outcomes
  • Acute Myocardial Infarction Research
  • Cardiac, Anesthesia and Surgical Outcomes
  • Central Venous Catheters and Hemodialysis
  • Acute Ischemic Stroke Management
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Cardiac Health and Mental Health
  • Biomarkers in Disease Mechanisms
  • Venous Thromboembolism Diagnosis and Management
  • Lipoproteins and Cardiovascular Health
  • Pulmonary Hypertension Research and Treatments
  • Peripheral Artery Disease Management
  • Vascular Procedures and Complications

University of Padua
2021-2024

Gruppo di Ricerca Geriatrica
2024

Alfaisal University
2023

King Faisal Specialist Hospital & Research Centre
2023

Azienda Ospedaliera di Padova
2021

Coronary access (CA) after transcatheter aortic valve replacement (TAVR) with supra-annular heart valves (THV) can be challenging. Specific Evolut R/Pro and Acurate Neo THVs orientations are associated reduced neo-commissure overlap coronary ostia, while SAPIEN 3 THV cannot oriented. With the ALIGN-ACCESS study (TAVR Commissural Alignment Followed by Access), we investigated impact of commissural alignment on feasibility CA TAVR.We performed angiography TAVR intra-annular 3, R/Pro, in 206...

10.1161/circinterventions.121.011045 article EN Circulation Cardiovascular Interventions 2022-02-01

Background The impact of transcatheter aortic valve replacement (TAVR) leaflet design on long-term device performance is still unknown. This study sought to compare the clinical and hemodynamic outcomes intra- (IA) versus supra-annular (SA) TAVR designs up-to 10-years following implantation. Methods Consecutive patients with at least 5-years follow-up for severe symptomatic stenosis from June 2007 December 2016 were included. Bioprosthetic failure (BVF) deterioration (HVD) defined according...

10.3389/fcvm.2022.924958 article EN cc-by Frontiers in Cardiovascular Medicine 2022-06-08

In patients undergoing transcatheter aortic valve implantation (TAVI), the presence of a low-flow, low-gradient (LFLG) status has been associated with higher mortality at short-term follow-up.

10.4244/eij-d-24-00442 article EN EuroIntervention 2024-11-01

Objective The European Society of Cardiology guidelines have recently defined new cut-offs for pulmonary hypertension (PH) and vasculature resistance (PVR; median artery pressure (mPAP) >20 instead 25 mm Hg PVR >2 3 Wood unit). prognostic value this updated classification after transcatheter aortic valve implantation (TAVI) is unknown. Methods 579 consecutive patients treated by TAVI with preprocedural right heart catheterisation evaluation were included. Patients grouped as: (1) no...

10.1136/heartjnl-2023-322881 article EN Heart 2023-07-06

Clinical evidence has emphasized the importance of coronary plaques’ characteristics, rather than lumen stenosis, for outcome cardiovascular events. Coronary computed tomographic angiography (CCTA) a well-established role as non-invasive tool assessing plaques. The aim this study was to compare clinical characteristics and CCTA-derived information stable patients with non-severe plaques in predicting major adverse cardiac events (MACEs) during follow-up. We retrospectively selected 371 (64%...

10.3390/diagnostics12061446 article EN cc-by Diagnostics 2022-06-12

Among vascular closure devices (VCDs), the novel collagen plug-based MANTA VCD is first designed for large bore percutaneous access. We aimed to assess features and predictors of access-site complications in an unselected trans-femoral transcatheter aortic valve replacement (TF-TAVR) population.Patients undergoing arteriotomy with 18F following TF-TAVR at a tertiary care center from September 2019 January 2021 were prospectively analyzed. Primary Outcome was access-site-related according...

10.3389/fcvm.2022.832242 article EN cc-by Frontiers in Cardiovascular Medicine 2022-02-28

Although the primary cause of death in COVID-19 infection is respiratory failure, there evidence that cardiac manifestations may contribute to overall mortality and can even be death. More importantly, it recognized associated with a high incidence thrombotic complications.Evaluate if coronary artery calcium (CAC) score was useful predict in-hospital (in-H) patients COVID-19. Secondary end-points were needed for mechanical ventilation intensive care unit admission.Two-hundred eighty-four...

10.1002/clc.23809 article EN Clinical Cardiology 2022-03-30

To assess the impact of conventional transcatheter heart valve (THV) commissural alignment techniques on THV/coronary overlap and coronary access (CA) after aortic replacement (TAVR) in bicuspid (BAV).Specific Evolut Pro/Pro + Acurate Neo2 THV orientations are associated with reduced neo-commissural ostia tricuspid anatomy. Whether standard orientation effective also setting BAV anatomy has not been studied.The DA VINCI (Definition trAnscatheter Valve orIeNtation biCuspId valve) pilot study...

10.3389/fcvm.2022.1056496 article EN cc-by Frontiers in Cardiovascular Medicine 2022-12-12

Abstract Background Spontaneous coronary artery dissection (SCAD) is one of the causes acute syndrome, myocardial infarction (MI) and sudden death. Although gold standard for diagnosis invasive angiography, Coronary Computed Tomography Angiography (CCTA) a new useful tool follow–up (FU). Treatment could involve conservative or an approach with percutaneous intervention (PCI) bypass grafting. AIMS: 1) analyze clinical CCTA features at baseline patients SCAD; 2) evaluate anatomic outcome...

10.1093/eurheartjsupp/suad111.076 article EN European Heart Journal Supplements 2023-05-01

Abstract Funding Acknowledgements Type of funding sources: None. Background Spontaneous coronary artery dissection (SCAD) is one the causes acute syndrome (ACS), myocardial infarction (MI) and sudden death (SD). Diagnosis done with angiography (CA); nevertheless, computed tomography (CCTA) a new useful tool in diagnosis at follow-up. Treatment could involve conservative approach or an invasive percutaneous intervention (PCI) bypass grafting (CABG). Purpose 1) analyze clinical CCTA features...

10.1093/ehjci/jead119.070 article EN European Heart Journal - Cardiovascular Imaging 2023-06-01

Abstract Background Computed tomographic (CT) coronary angiography represents a non–invasive approach to assess plaque characteristics that provides information change treatment of artery disease (CAD) and asses risk stratification. Purpose Analyze the differences in composition between patients with different features: soft unstable plaques, hard stable plaques no plaques; identify whether there is relationship density pericoronary fat attenuation index (pFAI). Materials methods: 372...

10.1093/eurheartj/suac011.046 article EN European Heart Journal Supplements 2022-05-01

Abstract Introduction Transcatheter aortic valve replacement (TAVR) has become the treatment of choice in elderly patients affected by severe stenosis (AS). In with low-flow low-gradient (LFLG) AS, a clear benefit TAVR over conservative been demonstrated. Notwithstanding, classical LFLG (cLFLG) AS have shown worse early post-procedural outcomes compared to those high-gradient (HG) AS. Purpose Given absence data, we aimed evaluate long-term survival (up 10 years) after cLFLG and paradoxical...

10.1093/eurheartj/ehac544.1570 article EN European Heart Journal 2022-10-01

Abstract Background Pulmonary embolism (P.E.) is defined as an acute occlusion/subocclusion of pulmonary vascular vessels with a ranging clinical manifestation. A reperfusion therapy (preferably systemic thrombolysis) represents the first line for high-risk patients. However, percutaneous treatment option should be considered when thrombolysis contraindicated or has failed. Case report 73 y.o. male, former smoker history hypertension and dyslipidemia, was admitted hemorrhagic stroke...

10.1093/eurheartjsupp/suac121.252 article EN European Heart Journal Supplements 2022-12-14

Abstract Background Spontaneous coronary artery dissection (SCAD) is one of the causes acute syndrome (ACS) and sudden death (SD). This condition predominantly affects young women with a few or no conventional risk factors for CAD. Diagnosis traditionally made invasive angiography (ICA); nevertheless, computed tomography (CCTA) going to be new useful tool in diagnosis at follow-up these patients. Conventional treatment could involve conservative approach medical therapy an percutaneous...

10.1093/eurheartjsupp/suac121.178 article EN European Heart Journal Supplements 2022-12-14

Abstract Although the primary cause of death in COVID-19 infection is respiratory failure, there are evidences that cardiac manifestations may contribute to overall mortality and can even be death. More importantly, it recognized associated with a high incidence thrombotic complications. Two-hundred-eighty-four patients proven SARS-CoV-2 who had non-contrast Chest CT at our facility were analysed for coronary calcium score. Clinical radiological data retrieved. Patients higher inflammatory...

10.1093/eurheartj/suab135.016 article EN European Heart Journal Supplements 2021-12-01

In the last decades, wide use of surgical aortic bioprostheses translated into an increased rate valve degeneration and dysfunction. However, most patients are excluded from re-do due to high or prohibitive operative risk. this clinical context, valve-in-valve transcatheter implantation (ViV-TAVI) has been shown be effective. Nevertheless, some relevant concerns, such as elevated residual transvalvular gradient coronary artery obstruction, still remain. Detailed information regarding...

10.1714/3723.37138 article EN PubMed 2021-12-01
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