A5035071000- Salmonella and Campylobacter epidemiology
- Mycobacterium research and diagnosis
- Urinary Tract Infections Management
- Identification and Quantification in Food
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Mycology
- Antibiotics Pharmacokinetics and Efficacy
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Medical Device Sterilization and Disinfection
- COVID-19 epidemiological studies
- Occupational exposure and asthma
- Pediatric Urology and Nephrology Studies
- Listeria monocytogenes in Food Safety
- Viral Infections and Outbreaks Research
- Hepatitis B Virus Studies
- Pneumonia and Respiratory Infections
- Indoor Air Quality and Microbial Exposure
- Spinal Dysraphism and Malformations
- Tuberculosis Research and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Fecal contamination and water quality
- Intestinal Malrotation and Obstruction Disorders
- Bacillus and Francisella bacterial research
- Viral gastroenteritis research and epidemiology
University of Cincinnati
2024
Emory University
2018-2021
University of Cincinnati Medical Center
2008-2013
Abstract Background Gepotidacin (GEP) is a novel, bactericidal, first-in-class triazaacenaphthylene antibacterial that inhibits bacterial DNA replication by unique mechanism of action, distinct binding site, and provides well-balanced inhibition (for most uncomplicated urinary tract infection (uUTI) uropathogens N. gonorrhoeae)) two different Type II topoisomerase enzymes. We present the activity GEP against molecularly characterized gonorrhoeae isolates collected from patients in Australia,...
Abstract Background Gepotidacin (GEP) is a novel oral antibacterial under development for the treatment of uncomplicated urinary tract infection (uUTI) and gonorrhea. This study reports drug resistance rates large collections Escherichia coli (EC) Klebsiella pneumoniae (KPN) isolates from GEP uropathogen global surveillance studies vs 2 Phase 3 (Ph3) uUTI trials. Methods A total (G [global]/US [a subset United States]) 4481/2763 EC 1769/1296 KPN were collected (2019–2022). From an unbiased...
Abstract Background Gepotidacin is a novel, bactericidal, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by unique mechanism of action, distinct binding site and provides well-balanced inhibition (for most uUTI uropathogens) two different type II topoisomerase enzymes. This study reports on the in vitro activity gepotidacin other oral antibiotics tested against contemporary Klebsiella pneumoniae clinical isolates collected from patients with urinary...
Abstract Background Gepotidacin (GEP) is a novel, bactericidal, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by unique mechanism of action, distinct binding site and provides well-balanced inhibition (for most uUTI uropathogens) two different type II topoisomerase enzymes. This study reports the activity GEP other oral antibiotics against K. pneumoniae, including molecularly characterized fluoroquinolone (FQ) not susceptible (NS) isolates collected...
Abstract Background Gepotidacin (GEP) is a novel, bactericidal, first-in-class triazaacenaphthylene antibacterial that inhibits bacterial DNA replication by unique mechanism of action, distinct binding site, and provides well-balanced inhibition (for most uncomplicated urinary tract infection [uUTI] uropathogens Neisseria gonorrhoeae) two different type II topoisomerase enzymes. GEP recently completed phase 3 trials for the treatment uUTI. This study reports activity other oral...
Abstract Background Gepotidacin (GEP) is a novel, bactericidal, first-in-class triazaacenaphthylene antibacterial that inhibits bacterial DNA replication by unique mechanism of action, distinct binding site and provides well-balanced inhibition (for most uncomplicated urinary tract infections [uUTI] uropathogens Neisseria gonorrhoeae) two different type II topoisomerase enzymes GEP completed phase 3 trials for treatment uUTI This study reports the activity other oral antibacterials against...
Background Antecedents for infantile hypertrophic pyloric stenosis (IHPS) vary across studies; therefore, we conducted a multistate, population‐based retrospective study of the prevalence and descriptive epidemiology IHPS in United States (US). Methods Data cases ( n = 29,554) delivered from 1999–2010 enumerated 11 US birth defect surveillance programs, along with data live births 14,707,418) within same period jurisdictions, were analyzed using Poisson regression to estimate per 10,000...
Enteric fever is a severe systemic infection caused by Salmonella enterica serovar Typhi (ST) and Paratyphi A (SPA). Detection of ST SPA in wastewater can be used as surveillance strategy to determine burden identify priority areas for water, sanitation, hygiene interventions vaccination campaigns. However, sensitive specific detection environmental samples has been challenging. In this study, we developed validated two methods concentrating detecting ST/SPA from wastewater: the Moore swab...
Background Despite the development and enforcement of preventive guidelines by governments, COVID-19 continues to spread across nations, causing unprecedented economic losses mortality. Public places remain hotspots for transmission due large numbers people present; however measures are poorly enforced. Supermarkets among high-risk establishments high interactions involved, which makes compliance with paramount importance. However, until now, there has been limited evidence on set prevention...
ABSTRACT An ATP-based biocide susceptibility assay for mycobacteria was developed by optimizing the cell lysis and conditions. Compared to conventional agar plating method, rapid (1.5 h) showed high sensitivity specificity as determined receiver operating characteristic (ROC) analysis. The test species, M ycobacterium immunogenum , M. chelonae abscessus various susceptibilities glutaraldehyde- isothiazolone-based biocides.
Nontuberculous mycobacteria (NTM) have been associated with hypersensitivity pneumonitis in machinists. Only two species of NTM, namely Mycobacterium immunogenum and chelonae, reported thus far to the ability colonize contaminated metalworking fluids (MWFs). Here, we report, for first time, presence characterization (phenotypic genotypic) a third species, abscessus, colonizing these harsh alkaline machining fluids. Two morphotypes, smooth (S) rough (R), were isolated (two isolates each) from...
ABSTRACT Mechanisms underlying susceptibility to anthrax infection are unknown. Using a phylogenetically diverse panel of inbred mice and spores Bacillus anthracis Ames, we investigated host pulmonary anthrax. Susceptibility profiles for survival time organ pathogen load differed across strains, indicating distinct genetic controls. Tissue kinetics analysis showed greater systemic dissemination in susceptible DBA/2J (D) but higher terminal bacterial resistant BALB/cJ (C) mice. Interestingly,...
Microorganisms colonizing modern water-based metalworking fluids (MWFs) have been implicated in various occupational respiratory health hazards to machinists. An understanding of the exposure risks from specific microbial groups/genera/species (pathogenic or allergenic) and their endotoxins need for strategies effective, timely fluid management warrant real-time extended tracking establishment diversity prevailing fluid-related factors. In current study, community composition, succession,...
Understanding of the occupational exposure risk scenario and disease etiology associated with industrial metalworking fluids (MWFs) requires knowledge development composition their microbial diversity in relation to underlying fluid management factors. In this study, a managed synthetic MWF operation freshly recharged following dumping, cleaning, recharge (DCR) process was tracked real time for community changes over period 1.25 years (65 weeks). The developed very high bacterial counts...
Graphical Abstract Phages infecting Bacteroides fragilis strain GB-124 and non-source specific somatic coliphages (SOMCPH) were deployed for identification of fecal contamination pathways in Kolkata, India. Analyses environmental samples representative nine different exposure pathways, pooled sewage from shared community toilets pumping stations showed the presence both SOMCPH phages all sample types.
We conducted a needs assessment among parents/guardians of children and independent adults with spina bifida, served by the Spina Bifida Association Georgia (SBAGA). The objective was to assess if SBAGA is adequately meeting its constituents identify challenges opportunities improve services.The survey targeted all members in 2017. Survey questions were drafted separately for children, bifida. Both closed- open-ended response options provided. pilot-tested, administered English Spanish,...
Abstract Enteric fever is a severe systemic infection caused by Salmonella enterica serovar Typhi (ST) and Paratyphi A (SPA). Detection of ST SPA in wastewater can be used as surveillance strategy to determine burden identify priority areas for water, sanitation, hygiene interventions vaccination campaigns. However, sensitive specific detection environmental samples has been challenging. In this study, we developed validated two methods concentrating detecting ST/SPA from wastewater: the...
Abstract Background Gepotidacin is a novel, bactericidal, first-in-class triazaacenapthylene antibiotic that inhibits bacterial DNA replication by distinct mechanism of action and binding site provides well-balanced inhibition 2 different Type II topoisomerase enzymes. This study reports on the in vitro activity gepotidacin other oral antibiotics when tested against contemporary Escherichia coli Staphylococcus saprophyticus clinical isolates collected from patients with UTIs for uUTI global...
The protocol describes method for qualitative detection (presence/ absence) of Salmonella Typhi and Paratyphi A on produce by enrichment culture followed real-time PCR.
The protocol describes method for qualitative detection (presence/ absence) of Salmonella Typhi and Paratyphi A in street food by enrichment culture followed real-time PCR.