A5062651541- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Development and Disorders
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Advanced Fluorescence Microscopy Techniques
- Zebrafish Biomedical Research Applications
- Health disparities and outcomes
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Neuroscience, Education and Cognitive Function
- Retinal Diseases and Treatments
- Health and Well-being Studies
- Signaling Pathways in Disease
- Conducting polymers and applications
- stochastic dynamics and bifurcation
- Health and Wellbeing Research
- Ion channel regulation and function
- Climate Change and Health Impacts
- Supramolecular Self-Assembly in Materials
- Nerve injury and regeneration
University College London
2015-2025
King's College London
2013-2017
Max Planck Institute of Neurobiology
2008-2013
Max Planck Society
2008-2010
Boston University
2004-2008
A fundamental property of neuronal circuits is the ability to adapt altered sensory inputs. It well established that functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, degree which plasticity inhibitory neurons accompanies less clear. Here, we use two-photon imaging monitor fine structure mouse visual cortex after deprivation induced retinal lesions. We find a subset carry dendritic spines, form glutamatergic...
We summarize here the results presented and subsequent discussion from meeting on Integrating Hebbian Homeostatic Plasticity at Royal Society in April 2016. first outline major themes meeting. next provide a synopsis of outstanding questions that emerged end finally suggest potential directions research we believe are most promising to develop an understanding how these two forms plasticity interact facilitate functional changes brain.This article is part themed issue 'Integrating...
In hippocampal slice models of epilepsy, two behaviors are seen: short bursts electrical activity lasting 100 msec and seizure-like seconds. The originate from the CA3 region, where there is a high degree recurrent excitatory connections. Seizures CA1, fewer attempting to explain this behavior, we simulated model networks neurons using several types neurons. were connected in ring containing predominantly local connections some long-distance random connections, resulting small-world network...
Homeostatic regulation has been shown to restore cortical activity in vivo following sensory deprivation, but it is unclear whether this recovery uniform across all cells or specific a subset of the network. To address issue, we used chronic calcium imaging behaving adult mice examine individual excitatory and inhibitory neurons same region layer 2/3 monocular visual cortex enucleation. We found that only fraction homeostatically recover after deprivation show no recovery. Prior did were...
Background: The global population is experiencing a demographic shift towards older ages, which has the potential to increase prevalence of ageing-related diseases and associated healthcare costs. Promoting healthy ageing behaviours, such as physical social activity, been shown reduce disability frailty among people improve their life satisfaction. To this aim, several Healthy Ageing Centres have established across nine municipalities in Bosnia Herzegovina support behaviours populations....
The use of transgenic mice in which subtypes neurons are labeled with a fluorescent protein has greatly facilitated modern neuroscience research. GAD65-GFP mice, have GABAergic interneurons GFP, widely used many research laboratories, although the properties cells not been studied detail. Here we investigate these hippocampal area CA1 and show that they constitute ∼20% this area. majority them expresses either reelin (70±2%) or vasoactive intestinal peptide (VIP; 15±2%), while expression...
Signal and noise correlations, a prominent feature of cortical activity, reflect the structure function networks during sensory processing. However, in addition to reflecting network properties, correlations are also shaped by intrinsic neuronal mechanisms. Here we show that spike threshold transforms creating nonlinear interactions between signal inputs; even when input correlation is constant, spiking varies with both strength inputs. We characterize these effects systematically vitro mice...
Previous studies have demonstrated the presence of functional glycine receptors (GlyRs) in hippocampus. In this work, we examine baseline activity and activity-dependent modulation GlyRs region CA1. We find that strychnine-sensitive are open resting CA1 pyramidal cell, creating a state tonic inhibition “shunts” magnitude EPSPs evoked by electrical stimulation Schaffer collateral inputs. This GlyR-mediated shunting conductance is independent presynaptic rate; however, pairs postsynaptic...
Homeostatic regulation is essential for stable neuronal function. Several synaptic mechanisms of homeostatic plasticity have been described, but the functional properties synapses involved in homeostasis are unknown. We used longitudinal two-photon imaging dendritic spine calcium signals visual and retrosplenial cortices awake adult mice to quantify sensory deprivation-induced changes responses functionally identified spines. found that spines whose activity selectively correlated with...
Transgenic mice with mosaic, Golgi-staining-like expression of enhanced green fluorescent protein (EGFP) have been very useful in studying the dynamics neuronal structure and function. In order to further investigate molecular events regulating structural plasticity, it would be express multiple proteins same sparse neurons, allowing co-expression functional or co-labeling subcellular compartments other proteins. However, has difficult obtain reproducible subset neurons for direct comparison...
The impacts of climate change on mental health are starting to be recognized and may exacerbated for populations at disproportionate risk or inequalities, including some people living in low- middle-income countries, children, indigenous populations, rural communities, among others. Here, we conduct a rapid scoping review reviews summarize the research date risk. This highlights direct indirect effects change, common issues that have been studied related events, date. outlines key gaps field...
This work investigates the effect of synaptic input location on both single cell dynamics and small network behavior. Using spike time response curves (STRCs), we measure how inputs expected firing a periodically cell. By changing from soma, most convenient place to record, dendrite, where excitatory occur biologically, see difference in effects these inputs. Dendritic given early interspike interval (ISI) causes greatest advance time. Somatic when later ISI. The differences between STRCs...
Abstract Homeostatic regulation is essential for neuronal function. Several synaptic mechanisms of homeostatic plasticity have been described, but the functional properties synapses involved in homeostasis are unknown. We used longitudinal two-photon imaging dendritic spine calcium signals visual and retrosplenial cortices awake mice to quantify sensory deprivation-induced changes responses functionally identified spines. found that spines whose activity selectively correlated with intrinsic...