A5063161362- Neurogenetic and Muscular Disorders Research
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Medical Imaging Techniques and Applications
- Photodynamic Therapy Research Studies
- Electrical and Bioimpedance Tomography
- Pluripotent Stem Cells Research
- Amyotrophic Lateral Sclerosis Research
- Synthesis and Biological Evaluation
- Central Venous Catheters and Hemodialysis
- Click Chemistry and Applications
- Metabolism, Diabetes, and Cancer
- Muscle Physiology and Disorders
- Nanoplatforms for cancer theranostics
- CRISPR and Genetic Engineering
- Synthesis and biological activity
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Dialysis and Renal Disease Management
Stanford University
2018-2025
Stratford University
2024
Gladstone Institutes
2024
Palo Alto University
2022
Efforts to genetically reverse C9orf72 pathology have been hampered by our incomplete understanding of the regulation this complex locus. We generated five different genomic excisions at
Despite advances in treatments, multiple myeloma (MM) remains an incurable cancer where relapse is common. We developed a circulating tumor DNA (ctDNA) approach order to characterize genomics, monitor treatment response, and detect early MM. By sequencing 412 specimens from 64 patients with newly diagnosed or relapsed/refractory disease, we demonstrate the correlation between ctDNA key clinical biomarkers, as well patient outcomes. further extend our simultaneously track CAR-specific...
Abstract Introduction: Localized cancers are increasingly treated with neoadjuvant therapies prior to resection. For operable breast cancers, this approach can aid in breast-conservation, therapeutic response assessment, and prognostication. patients residual disease, addition of adjuvant therapy reduce recurrence risk improve outcomes. Pathological assessments responses, however, imperfectly predict survival, resulting under- over-treatment many patients. Current liquid biopsies also...
To circumvent Warburg effect, several clinical trials for different cancers are utilising a combinatorial approach using metabolic reprogramming and chemotherapeutic agents including metformin. The majority of these interventions work via indirectly activating AMP-activated protein kinase (AMPK) to alter cellular metabolism in favour oxidative phosphorylation over aerobic glycolysis. effect drugs is dependent on glycaemic insulin conditions. Therefore, development small molecules, which can...
Triple negative breast cancer is an aggressive, heterogeneous disease with high recurrence and metastasis rates even modern chemotherapy regimens thus in need of new therapeutics. Here, three novel synthetic analogues chalcones, plant-based molecules that have demonstrated potency against a wide variety cancers, were investigated as potential therapeutics for triple cancer. These compounds exhibit IC50 values ∼5 μM cell lines are more potent than nontumor according to viability experiments....
Abstract Peritoneal dialysis (PD) patients are at high risk for peritonitis, an infection of the peritoneum that affects 13% PD users annually. Relying on subjective peritonitis symptoms results in delayed treatment, leading to hospitalisation costs, peritoneal scarring, and premature transition haemodialysis. We have developed tested a low-cost, easy-to-use technology uses microscopy image analysis screen across effluent drain tube. Compared other technologies, our prototype is made from...
Abstract Background: Neoadjuvant chemotherapy (NAC) for locally advanced breast cancer can down-stage disease prior to surgery, monitor chemo-sensitivity, and provide key prognostic information via pathologic response that guides adjuvant treatment. Greater residual as assessed by the burden (RCB) index is associated with inferior outcomes but imperfectly predicts recurrence, particularly in triple negative (TNBC) where there heterogeneity of across RCB scores. As an alternative PCR,...
Abstract Background Efforts to genetically reverse C9orf72 pathology have been hampered by our incomplete understanding of the regulation this complex locus. Method We generated five different genomic excisions at locus in a patient‐derived iPSC line and WT (11 total isogenic lines), examined gene expression pathological hallmarks C9 FTD/ALS motor neurons differentiated from these lines. Comparing series removed confounding effects backgrounds allowed us probe specific changes. A coding SNP...