A5016893692- Biochemical Analysis and Sensing Techniques
- Asymmetric Hydrogenation and Catalysis
- Molecular Sensors and Ion Detection
- Cancer, Hypoxia, and Metabolism
- Advanced Chemical Sensor Technologies
- Ammonia Synthesis and Nitrogen Reduction
- Metabolism and Genetic Disorders
- Chemical Reactions and Isotopes
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Analytical Chemistry and Sensors
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Hydrogen Storage and Materials
- Aluminum toxicity and tolerance in plants and animals
- Antibiotic Resistance in Bacteria
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Coordination Chemistry and Organometallics
- 14-3-3 protein interactions
- Heat shock proteins research
- Peroxisome Proliferator-Activated Receptors
Stanford University
2018-2024
Palo Alto University
2018-2022
Stanford Medicine
2019
University of California, Santa Cruz
2011-2017
Y-box binding protein-1 (YB-1) is a proto-oncogenic protein associated with translation regulation. It plays crucial role in the development and progression of triple-negative breast cancer (TNBC). In this study, we describe promising approach to inhibit YB-1 using SU056, small-molecule inhibitor. SU056 physically interacts reduces its expression, which helps restrain TNBC. Proteome profiling analysis indicates that inhibition by can alter proteins regulate translation, an essential process...
While alternative methods of preparing dichloroindium hydride (HInCl2) via the in situ reduction InCl3 using lithium amino borohydride (LAB) were explored, generation HInCl2 from by sodium (NaBH4) was also re-evaluated for comparison. The reductive capability InCl3/NaBH4 system found to be highly dependent on solvent used. Investigation 11B NMR spectroscopic analyses indicated that reaction with NaBH4 THF generates along borane–tetrahydrofuran (BH3·THF) situ. Nitriles underwent primary...
To circumvent Warburg effect, several clinical trials for different cancers are utilising a combinatorial approach using metabolic reprogramming and chemotherapeutic agents including metformin. The majority of these interventions work via indirectly activating AMP-activated protein kinase (AMPK) to alter cellular metabolism in favour oxidative phosphorylation over aerobic glycolysis. effect drugs is dependent on glycaemic insulin conditions. Therefore, development small molecules, which can...
With the aim of discerning between different sugar and alcohols biomedical relevance, such as gut permeability, arrays 2-component probes were assembled with up to six boronic acid-appended viologens (BBVs): 4,4′-o-BBV, 3,3′-o-BBV, 3,4′-o-BBV, 4,4′-o,m-BBV, 4,7′-o-PBBV, pBoB, each coupled fluorophore 8-hydroxypyrene, 1,3,6-trisulfonic acid trisodium salt (HPTS). These screened for their ability discriminate lactulose, l-rhamnose, 3-O-methyl-d-glucose, xylose. Binding studies mannitol,...
Although organoboronic acids are efficient high-throughput sugar sensors, they have not been pursued for gut permeability studies. A modification of the lactulose/mannitol assay is described by which small intestinal assessed at time urine collection using a lactulose/riboflavin ratio.Volunteers ingested 50mg riboflavin and either 5 g mannitol or 10 lactulose. Urine was collected 6 hrs. Riboflavin assayed autofluorescence. removed C18 solid phase extraction. Lactulose were then...
Abstract There remains a need in clinics and research to have simple sensitive detection systems that allow the quantification of sugar markers biomedical relevance such as sugars lactulose mannitol for noninvasive gut permeability assessment. We prepared new class boronic acid-appended naphthyl-pyridinium receptor compounds chemosensors. These were studied their ability act modular internal charge transfer (ICT) fluorescent probes or donor/acceptor pair ensembles where compound can quencher...
Surgical resection and radiotherapy are an effective treatment in many head neck squamous cell carcinomas (HNSCC), but others, the development of resistance limits efficacy permits disease progression. We developed a novel multiwell radiation dosing method to increase throughput our investigation activity podophyllotoxin SU093 acting as radiosensitizer HNSCC models FaDu SCC-25. These vitro studies showed that combining with 5 Grays ionizing acted synergistically apoptosis decrease its...
Surge protector: A two-component peroxynitrite-generating platform has been engineered to release peroxynitrite (PN) in situ under the control of light. The system, which is constructed by layering sol–gel matrices containing xanthine oxidase (bottom layer) and a metal nitrosyl (top layer), allows studies PN chemistry at varying fluxes its precursors.
To address carbohydrates that are commonly used in biomedical applications with low binding affinities for boronic acid based detection systems, two chemical modification methods were utilized to increase sensitivity. Modified analyzed using a component fluorescent probe on acid-appended viologen-HPTS (4,4'-o-BBV). Carbohydrates normally giving poor signals (fucose, l-rhamnose, xylose) subjected sodium borohydride (NaBH4) reduction ambient conditions 1 h yielding the corresponding sugar...
Methods for the in situ generation of dichloroindium hydride (HInCl 2 ) via reduction InCl 3 with various reducing agents, such as tributyltin (tributylstannane; Bu SnH), diisobutylaluminum (DIBAL-H), triethylsilane (Et SiH), lithium aminoborohydride (LAB), and sodium borohydride (NaBH 4 ), solvents are reviewed compared.The use /NaBH system addition to forming HInCl , also generated borane that was trapped BH -tetrahydrofuran (THF).Carefully controlling activity these agents allows...
Abstract Ovarian cancer, the most common gynecologic malignancy, is a leading cause of cancer deaths in women. Seventy percent patients at diagnosis present with stage III or IV disease, which tumor has disseminated beyond ovaries and pelvic organs to distant sites. Despite resection chemotherapy, 80% diagnosed advanced epithelial ovarian develop recurrent disease overall prognosis poor. Resistance chemotherapeutic agents such as carboplatin paclitaxel (taxane-based drugs) accounts for lack...
A natural compound screen identified several anticancer compounds, among which azapodophyllotoxin (AZP) was found to be the most potent. AZP caused decreased viability of both mouse and human lymphoma renal cell cancer (RCC) tumor-derived lines. Novel derivatives were synthesized screened identifying NSC750212 inhibit growth RCC in vitro vivo. nanoimmunoassay used assess mode action On basis structure its action, disrupts tubulin polymerization. Through desorption electrospray ionization...
Abstract Aberration in the protein translation can lead to changes expression that serve as drivers of tumor progression. Ribosomes are a molecular machine acts hub for synthesis, and dysregulation ribosome function is causative cancer formation. Our investigation on causes breast progression has identified small molecule ‘SU056’ shows efficacy against TNBC models. SU056 treatment inhibits growth clonogenic potential cells (MDA-MB-231, MDA-MB-468, SUM159, 4T1, EMT6 E0771), by arresting cell...
Abstract Review: 50 refs.
Abstract Nitriles containing halide moieties undergo tandem reduction giving dehalogenated amines such as (IV).
Abstract Hyperglycemic and hyper insulin condition are the signature symptoms for type two diabetes which is most favorable development of cancer. Women having a has 20-27% high risk to develop breast cancer including triple negative (TNBC). Microenvironment hyperglycemic, leads therapy resistance. According ‘Warburg’s effect’ cells consume amount glucose in comparison normal via aerobic glycolysis process. To take care this currently, several clinical studies going on combination 2...