A5086594436- Prostate Cancer Treatment and Research
- Veterinary Oncology Research
- Vector-Borne Animal Diseases
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Bird parasitology and diseases
- CAR-T cell therapy research
- Herpesvirus Infections and Treatments
- Oral and Maxillofacial Pathology
- Tannin, Tannase and Anticancer Activities
- Virus-based gene therapy research
- T-cell and Retrovirus Studies
- Protease and Inhibitor Mechanisms
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Helminth infection and control
- Travel-related health issues
- Advanced Breast Cancer Therapies
- Parasite Biology and Host Interactions
- Animal Disease Management and Epidemiology
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- Coccidia and coccidiosis research
- Brucella: diagnosis, epidemiology, treatment
Mayo Clinic in Florida
2021-2024
Jacksonville College
2021-2024
WinnMed
2021-2024
Sylvester Comprehensive Cancer Center
2024
Nemours Children’s Clinic
2021-2023
Bursa Uludağ Üni̇versi̇tesi̇
2012-2021
The Ohio State University
2019-2021
Ankara University
2003
Chemotherapy-induced peripheral neuropathy (CIPN), a side effect of chemotherapy, is particularly difficult to treat. We explored whether phosphosulindac (PS), modified NSAID, could treat CIPN.
Metastatic castration-resistant prostate cancer (mCRPC) is an aggressive malignancy with poor outcomes. To investigate novel therapeutic strategies, we characterized three new metastatic patient derived-tumor xenograft (PDTX) models and developed 3D spheroids from each to molecular targeted therapy combinations including CDK4/6 inhibitors (CDK4/6i) AKT (ATKi). tissue was collected PDTX were established using whole-exome sequencing. these PDTXs show resistance patterns test molecular-targeted...
Matrix Metalloproteinases (MMPs) are drivers of many diseases including cancer and established targets for drug development. Tissue inhibitors metalloproteinases (TIMPs) human proteins that inhibit MMPs being pursued the development anti-MMP therapeutics. TIMPs possess attractive properties a candidate, such as complete MMP inhibition, low toxicity immunogenicity, high tissue permeability others. A major challenge with TIMPs, however, is their formulation delivery, these quickly cleared from...
Matrix metalloproteinases (MMPs) are significant drivers of many diseases, including cancer, and established targets for drug development. Tissue inhibitors (TIMPs) endogenous MMP being pursued the development anti-MMP therapeutics. TIMPs possess attractive properties candidates, such as complete inhibition, low toxicity, immunogenicity, high tissue permeability. However, a major challenge with is their rapid clearance from bloodstream due to small size. This study explores method extending...
Matrix metalloproteases (MMPs) are endogenous proteases that responsible for degradation of extracellular matrix (ECM) proteins and cell surface antigens. The breakdown ECM participates in the local invasion distant metastases malignant tumors. Canine transmissible venereal tumor (CTVT) is a naturally occurring contagious round neoplasm dogs affects mainly external genitalia both sexes. CTVT generally locally invasive tumor, but also common puppies immunocompromised dogs. We investigated...
Abstract Background Osteoblastic bone metastasis represents the most common complication in men with prostate cancer (PCa). During progression and metastasis, PCa cells acquire properties similar to a phenomenon called osteomimicry, which promotes their ability metastasize, proliferate, survive microenvironment. The mechanism of osteomimicry resulting osteoblastic is unclear. Methods We developed characterized novel canine prostatic cell line (LuMa) that will be useful investigate...
Human Dickkopf-1 (Dkk-1) upregulates a noncanonical Wnt/JNK pathway, resulting in osteoclast stimulation, cell proliferation, and epithelial-to-mesenchymal transition (EMT) of cancer cells. Ace-1-Dkk-1, canine prostate (PCa) line overexpressing Dkk-1, was used to investigate Wnt signaling pathways PCa tumor growth. SP600125, JNK inhibitor, examine whether it would decrease growth bone phenotype cells vitro vivo. Ace-1-VectorYFP-Luc Ace-1-Dkk-1YFP-Luc were transplanted subcutaneously, while...
Adult T-cell leukemia/lymphoma has a unique relationship to bone including latency in the marrow, and development of invasion, osteolytic tumors humoral hypercalcemia malignancy. To study these conditions, we established characterized novel mouse model ATL metastasis. Patient-derived cell lines three that do not express HTLV-1 oncoprotein Tax (ATL-ED, RV-ATL, TL-Om1), an vitro transformed human line with high expression (HT-1RV), negative lymphoma (Jurkat) were injected intratibially into...
Summary The detection of bovine viral diarrhea virus (BVDV) in a female Holstein calf presented with perosomus elumbis, congenital anomaly, is reported here. A cow dystocia was evaluated and an abnormal dead detected during vaginal examination. retrieved via caesarean section exhibited abnormalities characteristic PE, such as vertebral pelvic malformations. These were further confirmed using radiographic necropsy examinations. At cerebellar hypoplasia additional finding, which typical lesion...
A Maedi-Visna virus (MVV) infection was diagnosed in a 10-month-old lamb from Turkish flock. The animal suddenly showed nervous signs and died within 2 days. At necropsy, different pulmonary lesions were observed. Coenurus cerebralis cyst also present the right-brain hemisphere. Severe nonpurulent meningoencephalitis lymphoproliferative pneumonia detected by histopathology. MVV proviral DNA demonstrated polymerase chain reaction (PCR) formalin-fixed paraffin-embedded samples collected brain...
This report describes the inflammation caused by Capillaria hepatica in liver of a female stray dog approximately 2 months old for first time Turkey. Histopathological examination revealed severe granulomatous hepatitis with occasional adult nematodes and abundant eggs hepatic parenchyma. The present case differs from other capillariasis cases age presence mature parasites inflammation.
A 4-year old, primiparous, female Anatolian Shepherd dog was presented for evaluation of type II vaginal prolapse with alopecia the left perineal skin. Hematological analyses demonstrated leukocytosis and thrombocytopenia. Estradiol (E2) progesterone (P4) levels were 156 pg/mL 2.3 ng/mL, respectively. The smear predominantly (at least 80%) made up anuclear superficial cells. An abdominal ultrasonography revealed a heterogeneous multicystic mass anechoic areas adjacent to caudal pole kidney....
This paper describes a case of fibrinopurulent epididymitis and orchitis in Merino ram owing to Brucella melitensis biovar 3, detected by histopathology, bacteriology, PCR. Gross lesions included enlargement the scrotum abundant fibrinous exudate adhesions between testicular tunics. Histopathologic were characterized epididymal abscesses atrophy. B. was cultured from as well internal organs ram. After conventional biotyping procedures applied, isolate identified 3. The also confirmed spp....
Common magpies (Corvidae: Pica pica) distribute through rural and urban areas of Turkey. Because theirdistribution in urbanised regions, may have some potential infectious agents which relate to domestic animals andhumans. In this study, eight common brought the animal hospital need medical intervention were examined for endo-parasites bacteria a one-year period. Additionally, histopathologic examinations with related organs carried out along withendo-parasitical, cytological microbial...
ABSTRACT Most thyroid cancer deaths are attributed to a subset of poorly differentiated, metastatic tumors. To improve treatment options for these aggressive cancers, we developed novel thyroid-stimulating hormone receptor (TSHR)-targeted chimeric antigen T (CART) cell therapy, which demonstrated antigen-specific activation and antitumor efficacy against TSHR-overexpressing lines in vitro vivo . However, de- differentiated cancers downregulate TSHR. We therefore potent strategy by combining...
Abstract Oncocytic carcinoma (Hurthle cell carcinoma) has the highest incidence of metastasis among differentiated thyroid cancers. Metastatic disease is reported at initial diagnosis in 10-20% patients and 34% overall. Thyroid-stimulating hormone receptor (TSHR) expression limited to gland. It abundantly expressed on tumor cells, making TSHR a compelling target for advanced cancer diagnostics therapeutics. We developed potent anticancer strategy treating oncocytic using novel stimulating...
<p>Supplementary Figure 4</p>
<p>Supplementary Figure 3</p>
<p>Supplementary Figure 6</p>
<p>Supplementary Figure 7</p>
<p>Supplementary Figure 1</p>
<p>Supplementary Figure 5</p>
<p>Supplementary Figure 2</p>