A5052040863- Sports Performance and Training
- Microbial Metabolites in Food Biotechnology
- Cardiovascular and exercise physiology
- Wheat and Barley Genetics and Pathology
- Exercise and Physiological Responses
- Thyroid Cancer Diagnosis and Treatment
- Food composition and properties
- Plant Physiology and Cultivation Studies
- Phytase and its Applications
- Muscle metabolism and nutrition
- Crop Yield and Soil Fertility
- Celiac Disease Research and Management
- Insect behavior and control techniques
- RNA Interference and Gene Delivery
- Botanical Research and Applications
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Mycotoxins in Agriculture and Food
- Epigenetics and DNA Methylation
- Economic and Financial Impacts of Cancer
- Nasal Surgery and Airway Studies
- Glycosylation and Glycoproteins Research
- Genetically Modified Organisms Research
- Hedgehog Signaling Pathway Studies
- Cocoa and Sweet Potato Agronomy
National Research Council
2022
University of Foggia
2012-2018
University of Perugia
2017
University of Palermo
1972-2014
Temple University
2008-2012
Philadelphia University
2012
Temple College
2012
University of Genoa
2009
University of Siena
2008
Istituto di Biologia e Biotecnologia Agraria
1959
Abstract MicroRNAs (miRs) are short endogenous RNAs that regulate gene expression by incomplete pairing with messenger RNAs. An increasing number of studies show mammalian microRNAs play fundamental roles in various aspects cellular function including differentiation, proliferation, and cell death. Recent findings demonstrating the presence mature neuronal dendrites suggest their possible involvement controlling local protein translation synaptic function. HIV‐1 Encephalopathy (HIVE) is a...
The breeding of citrus triploid hybrids started at Istituto Sperimentale per l'Agrumicoltura spell out in Acireale, Italy, 1978 (Starrantino and Reforgiato, 1981). strategy used has been to cross a monoembryonic 2x female parent with 4x male parent. imbalance between the embryo endosperm ploidy (3:4) makes seeds from such crossings incapable germinating vivo. However, vitro cultivation rescue embryos. In this paper we report main characteristics 22 different parents, including sweet orange [...
Abacavir is one of the most efficacious nucleoside analogues, with a well-characterized inhibitory activity on reverse transcriptase enzymes retroviral origin, and has been clinically approved for treatment AIDS. Recently, shown to inhibit also human telomerase activity. Telomerase seems be required in essentially all tumours immortalization subset cells, including cancer stem cells. In fact, many cells are dependent their continued replication therefore an attractive target therapy....
Survivin is involved in human cancer and responsible for aggressive biological behavior poor clinical outcomes several malignancies. Thus, we hypothesized that the upregulation of survivin protein expression may be enhanced parallel with transition toward a poorly differentiated phenotype thyroid carcinomas.The was evaluated, using standard linked streptavidin-biotin horseradish peroxidase technique technique, series 56 carcinomas (42 papillary, 4 differentiated, 10 anaplastic carcinomas)...
Epithelial-Mesenchymal Transition (EMT) and angiogenesis are crucial events for development of aggressive often fatal Oral Squamous Cell Carcinomas (OSCCs). Both promote cancer progression metastasis development, but while the former induces loss E-cadherin expression and, hence cadherin switching; latter produces hematic blood vessel neo-formation contribute to OSCC cell growth, tumor mass dissemination. Cyclooxygenase-2 (COX-2) has an important role, not only in angiogenic mechanisms, also...
A three-year study (2007-2009) was carried out on green asparagus under tunnel in Campania (southern Italy) with the purpose of verifying both possibility to practise organic management and annual double harvest order extend eco-compatible production period avoid expensive imports. Comparisons among eight experimental treatments were made. Treatments obtained by factorial combination two crop methods (conventional organic) four spring summer periods 90-day total duration (75 days plus 15...
In the last decade, nutritional and health benefits of Opuntia (Opuntia ficus-indica (L.) Mill.) were discussed by academic scientists private companies. particular, introduction this substance in frequently consumed foods, like, for example, pasta bakery products, could have a wide diffusion due to its rich composition polyphenols, vitamins, polyunsaturated fatty acids, amino acids. The identified natural cactus compounds are responsible biologically relevant activities including...
Obstructive sleep apnoea syndrome can cause growth delay in children. Adeno-tonsillectomy resolve the most cases. The aim ofour study is to examine modifications clinical and laboratory immunological parameters food intake changes OSAS childrenafter surgery. Twenty-eight children with severe associated adeno-tonsillar hypertrophy were submitted paediatric evaluation tocalculate auxologic (weight, height, BMI standard deviation scores), a blood draw evaluate (GH; IGF-1)...
Cdk9 and Cdk7 are cdc2-like serine/threonine kinases that stabilize RNA transcript elongation through polII carboxyl terminal domain (CTD) phosphorylation considered suitable targets for cancer therapy. The effects of flavopiridol siRNA-mediated inhibition and/or were analyzed in human glioblastoma prostate cell lines. One finding revealed could substitute each other CTD contrast to the vitro system. Thus, a simultaneous might be required both targeting malignant cells developing platform...
Simple epithelial keratins appear early during embryonic development and are expressed in non-stratified, ductal pseudo-stratified tissues. CK19, the lowest molecular weight keratin, is also basal layer of squamous epithelia mucosal surfaces. Previous studies have shown that High Risk-Human Papilloma Virus (HR-HPV) infection induces cell immortalization via E6 E7 viral proteins this, turn, impairs cytokeratin expression cancerous cells lines derived from uterine cervix. Here, we demonstrate...
Hyaluronic acid (HA) plays a significant role in tissue repair of mucosal surfaces and, consequently, surgical injury remodelling nasal mucosa.To assess the effect high-molecular-weight HA administered by aerosol on morphofunctional recovery ciliated cells damaged trauma.A single-blind, prospective, randomized trial was carried out with 94 patients who were randomly assigned, after endoscopic turbinoplasty, either to treatment saline solution irrigation (control group, n = 47) or douches...
The criteria of “Distinctness, Uniformity and Stability” as well a high "overall quality index” are used to register the Italian modern varieties national register. Differently, local conservation can be certified under different EU Directives having, overall objective, preservation biodiversity containment genetic erosion. In recent years, products derived from an-cient grains perceived healthier more sustainable by consumer, especially in Italy, with...
Aim of this work is to provide a detailed comparison clinical-pathologic features between well-differentiated and poorly differentiated tumors according their BRAF RASSF1A status. We analyzed methylation by MSP mutation LCRT-PCR with LightMix® kit V600E in neoplastic thyroid tissues. Immunohistochemical evaluation expression was also performed standard automated LSAB-HRP technique. An overall higher degree over-expression than normal parenchyma surrounding (P < 0.05) has been found all...
The main hypothesis of this work is that facultative and obligate heterofermentative Lactobacillus species can differently impact the final characteristics pizza. objective was to evaluate separately behaviors (OHS), such as sanfranciscensis, brevis, rossiae, (FHS), including plantarum, curvatus, in sourdoughs be used for pizza production. production experimental pizzas carried out with semolina (Triticum turgidum L. ssp. durum). acidification process—which followed by pH, total titratable...
Pasta is a staple food of the Mediterranean Diet, and it traditionally made durum wheat semolina. In Sicily, production its transformation into semolina, bread, pasta are well-developed economic sectors. For pasta, there wide supply commercial brands, whether coming from conventional industrial manufacturing or medium to small local handcrafted production. Both landraces, such as Timilia Russello, used for production, but landraces are, most, transformed pasta. The market has risen in recent...
The criteria of “Distinctness, Uniformity and Stability” as well a high “overall quality index” are used to register the Italian modern varieties national register. Differently, local conservation can be certified under different EU Directives that facilitate, an overall objective, preservation biodiversity containment genetic erosion. In recent years, products derived from ancient grains perceived healthier more sustainable by consumers, especially in Italy, with consequent higher market...
The contribution of fat oxidation to energy production during exercise is influenced by intensity exercise. aim this study was assess the relationship between highest value rate (FATmax) and oxygen uptake (VO2) in sedentary type 2 diabetes (T2D) patients vs healthy subjects. Sedentary T2D subjects were evaluated a graded test, detected. Data show that not impaired positive linear correlation FATmax both VO2 VO2max suggests even muscle oxidative capacity might increase response aerobic training.