A5032967875- Animal Nutrition and Physiology
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Animal Behavior and Welfare Studies
- Trypanosoma species research and implications
- Spanish Linguistics and Language Studies
- Research on Leishmaniasis Studies
- Fatty Acid Research and Health
- Neuroscience and Neural Engineering
- Synthesis and Biological Evaluation
- Microbial Metabolites in Food Biotechnology
- Advanced Memory and Neural Computing
- linguistics and terminology studies
- Peroxisome Proliferator-Activated Receptors
- Ovarian function and disorders
- EEG and Brain-Computer Interfaces
- Gut microbiota and health
- Genetic and phenotypic traits in livestock
- Ruminant Nutrition and Digestive Physiology
- Linguistics and Discourse Analysis
- Meat and Animal Product Quality
- Reproductive Physiology in Livestock
- Language, Metaphor, and Cognition
- Probiotics and Fermented Foods
- Seed Germination and Physiology
Icahn School of Medicine at Mount Sinai
2024
Nutrition Sciences (Belgium)
2017-2023
New York University
2015-2021
Royal Dutch Society for the Promotion of Dentistry
2020
Vlaams Instituut voor Biotechnologie
2019
Nutritional Research Foundation
2018
Ghent University
2002-2016
Dankook University
2016
University of York
2014
Universidad Pedro de Gante
2013
Silicon micromachining and thin-film technology were used to fabricate iridium stimulating arrays which can be excite discrete volumes of the central nervous system. multichannel probes with thicknesses ranging from 1 40 mu m arbitrary two-dimensional shape fabricated using a high-yield, circuit-compatible process. Iridium sites are shown have similar characteristics wire electrodes. Accelerated pulse testing over eight million 100 A biphasic current pulses on 8000 m/sup 2/ demonstrated...
The parasitic protists of the Trypanosoma genus infect humans and domestic mammals, causing severe mortality huge economic losses. most threatening trypanosomiasis is Chagas disease, affecting up to 12 million people in Americas. We report a way selectively kill by blocking glycosomal/peroxisomal import that depends on PEX14-PEX5 protein-protein interaction. developed small molecules efficiently disrupt This results mislocalization glycosomal enzymes, metabolic catastrophe, it kills...
Prebiotics can modulate gut fermentation and improve intestinal barrier function in mammals. First, inulin profile was tested a three-step vitro model of the piglet's gastro-intestinal tract combining hydrolysis – dialysis step to batch fermentation. Then, differential effects digested (after steps) or fermented step) on expression immune-related genes IPEC-J2 cells were investigated by high-throughput qPCR. Inulin associated with elevated short-chain fatty acids butyrate levels. Upregulated...
Contents Frozen‐thawed semen from six bulls with high (> 60%) and low (20–35%) in vitro fertility was used for studying the predictive value of simple sperm quality tests respect to fertilization (IVF) outcome as assessed by pronucleus (PN) formation ability. Sperm parameters, such concentration, motility, progressive live‐dead ratio, morphology, membrane integrity, mitochondrial activity acrosomal status were analysed using both conventional automatic techniques at three time points...
The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of African trypanosomiasis (HAT) Chagas disease. Drugs currently available to treat these neglected diseases leave much be desired. Herein we report optimization a novel class N-(2-(2-phenylthiazol-4-yl)ethyl)amides, carbamates, ureas, which rapidly, selectively, potently kill both species trypanosome. mode action compounds is unknown but does not involve CYP51 inhibition....
Lapatinib, an approved epidermal growth factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, causative agent human African trypanosomiasis (HAT). Previous work culminated in 1 (NEU-1953), which part series typically associated with poor aqueous solubility. In this report, we present various medicinal chemistry strategies that were used to increase solubility and improve physicochemical profile without sacrificing...
A probe designed for the highly selective long-term stimulation of neuronal assemblies in central nervous system is described. The micromachined multishank incorporates CMOS circuitry to control output current on 16 iridium oxide (IrO) electrode sites. Serial site addresses and amplitude data are loaded into at 4 MHz converted analog stimulus currents. dissipates only 80 mu W from +or-5-V supplies when not delivering currents uses five external leads. It permits IrO sites be activated by...
Abstract The inclusion of fibre-rich ingredients in diets is one possible strategy to enhance intestinal fermentation and positively impact gut ecology, barrier immunity. Nowadays, inulin-type fructans are used as prebiotics the feed piglets manipulate ecology for health purposes. Likewise, some by-products could be considered sustainable inexpensive reduce disorders at weaning. In present study, chicory root pulp, citrus rye bran soya hulls were tested a three-step vitro model piglet’s...
Abstract In the present study, efforts were made towards identifying carbohydrates and glycoproteins involved in bovine vitro fertilization (IVF). matured cumulus–oocyte complexes (COCs) inseminated presence of a variety to determine which glycoconjugates act as competitive inhibitors oocyte penetration. Among tested, D ‐mannose, fucoidan, dextran sulfate, fibronectin most potent penetration (90% or more inhibition), while L ‐fucose vitronectin inhibited rate lesser extent (around 50%...
Echium oil (source of stearidonic acid) and linseed α-linolenic were evaluated as alternatives for fish in the diet sows to increase docosahexaenoic acid (DHA) status offspring. The hypothesis was that echium would be more efficient than DHA concentration, it bypasses enzyme Δ6-desaturase. In addition, determined whether adding PUFA affected plasma oxidative status. Sows fed either a palm or containing 1% oil, from d 73 gestation during lactation (n = 16 per dietary treatment). Total...
Almost three decades have passed since Kachru (1985) proposed his three-circle model of World Englishes. Although this is often challenged, few would deny its significance in opening the dialogue and raising awareness issues related to The context project described paper South Korea, one what Kachru's refers as an ‘expanding circle country’. Reflecting on idea Korea country’, article briefly examines how has expanded continues expand a nation, juxtaposing it alongside university speaking...
Summary N‐3 polyunsaturated fatty acids ( PUFA ) are essential for foetal development. Hence, including n‐3 in the sow diet can be beneficial reproduction. Both amount and form (precursor vs . long chain of supplementation important this respect. Furthermore, have negative effects, such as decreased arachidonic acid ARA concentration increased oxidative stress. This study aimed to compare efficacy increase eicosapentaenoic EPA docosahexaenoic DHA concentrations piglet, when different linseed...
We investigated the use of citrus pulp (CP) as a novel prebiotic capable exerting microbiota and immunomodulating capacities to alleviate weaning stress. Inulin (IN), well-known prebiotic, was used for comparison. Hundred 28 male weaned piglets 21 days old were assigned 32 pens 4 each. Piglets one four treatments, i.e., control, IN supplemented at 0.2% (IN0.2%), CP either (CP0.2%) or 2% (CP2%). On d10-11 d31-32 post-weaning, pig per pen euthanized intestinal sampling evaluate growth...