A5040128628- Enzyme Structure and Function
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Photosynthetic Processes and Mechanisms
- Bacterial Genetics and Biotechnology
- Amino Acid Enzymes and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Protein Structure and Dynamics
- Probiotics and Fermented Foods
- Porphyrin Metabolism and Disorders
Philipps University of Marburg
2017-2024
Max Planck Institute for Terrestrial Microbiology
2020-2021
Loewe Center for Synthetic Microbiology
2020
Ectoine and hydroxyectoine are effective microbial osmostress protectants, but can also serve as versatile nutrients for bacteria. We have studied the genetic regulation of ectoine import catabolism in marine Roseobacter species Ruegeria pomeroyi identified three transcriptional regulators involved these processes: GabR/MocR-type repressor EnuR, feast famine-type regulator AsnC two-component system NtrYX. The corresponding genes widely associated with uptake catabolic gene clusters (enuR,...
Abstract The hydroxyacid glycolate is a highly abundant carbon source in the environment. Glycolate produced by unicellular photosynthetic organisms and excreted at petagram scales to environment, where it serves as growth substrate for heterotrophic bacteria. In microbial metabolism, first oxidized glyoxylate enzyme oxidase. recently described β-hydroxyaspartate cycle (BHAC) subsequently mediates carbon-neutral assimilation of into central metabolism ubiquitous Alpha- Gammaproteobacteria....
When faced with increased osmolarity in the environment, many bacterial cells accumulate compatible solute ectoine and its derivative 5-hydroxyectoine. Both compounds are not only potent osmostress protectants, but also serve as effective chemical chaperones stabilizing protein functionality. Ectoines energy-rich nitrogen carbon sources that have an ecological impact shapes microbial communities. Although biochemistry of 5-hydroxyectoine biosynthesis is well understood, our understanding...
The hydroxyacid glycolate is a highly abundant carbon source in the environment. Glycolate produced by unicellular photosynthetic organisms and excreted at petagram scales to environment, where it serves as growth substrate for heterotrophic bacteria. In microbial metabolism, first oxidized glyoxylate enzyme oxidase. recently described β-hydroxyaspartate cycle (BHAC) subsequently mediates carbon-neutral assimilation of into central metabolism ubiquitous Alpha- Gammaproteobacteria. Although...
The compatible solutes ectoine and 5-hydroxyectoine are widely synthesized by bacteria as osmostress protectants. These nitrogen-rich tetrahydropyrimidines can also be exploited nutrients microorganisms. Many ectoine/5-hydroxyectoine catabolic gene clusters associated with a regulatory (enuR: nutrient utilization regulator) encoding repressor protein belonging to the MocR/GabR sub-family of GntR-type transcription factors. Focusing on EnuR from marine bacterium Ruegeria pomeroyi, we show...