A5079117637- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Liver Disease Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Cardiovascular Function and Risk Factors
- Obesity and Health Practices
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Adrenal and Paraganglionic Tumors
- Ovarian function and disorders
- Pancreatic function and diabetes
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ion channel regulation and function
- Metabolism, Diabetes, and Cancer
- Dialysis and Renal Disease Management
- Retinal Imaging and Analysis
KPC Medical College and Hospital
2013-2025
Medical College and Hospital, Kolkata
2012-2024
National University Hospital
2014
Institute of Post Graduate Medical Education and Research
2013-2014
Bose (United States)
2014
North Bengal Medical College and Hospital
2012
Abstract Introduction: Cortisol concentration is often estimated by competitive chemiluminescent immunoassays, which are prone to interference due cross-reactivity. The extent of inconsistent across different adrenal disorders and among analyzers. Although liquid chromatography-mass spectrometry (LC-MS/MS) possesses better analytical specificity, it not widely available. We aimed compare cortisol values measured four analyzers disorders. Methods: concentrations were in the serum patients...
The risk of nonalcoholic fatty liver disease (NAFLD) is increased significantly in individuals having Type 2 diabetes mellitus (T2DM) and the presence T2DM enormously drives NAFLD progression. However, clinical practice, it overlooked despite significant effects T2DM. Our study aimed to estimate prevalence patients from eastern region India. This cross-sectional assessed 132 for NAFLD. Anthropometry lipid estimations were done all individuals. Hepatic fibrosis was diagnosed by transient...
The incidence of coronary artery disease (CAD) is increasing in India. Recent data suggesting insulin resistance can predict cardiovascular independently the other risk factors, such as hypertension, visceral obesity, or dyslipidemia, so a focus on relation between acute syndrome (ACS) and relevant. Several studies addressing serum lipoprotein ratios surrogates for have found promising results. We analyzed association with homeostatic model assessment (HOMA-IR).One hundred non-diabetic...
Recent research has revealed that genetic defects due to mutation in the Thyroid Peroxidase (TPO ) gene can lead thyroid dysfunction population. We aimed study association between TPO and patients with hypothyroidism found adult age. Two hundred consecutive treatment naive hypothyroid (age ≥ 18 years) (cases) who were negative for anti antibody their corresponding sex age matched two normal individuals (controls) enrolled. The 17 exonic regions of amplified sequenced directly. identified 6...
Thyroid peroxidase (TPO) is the key enzyme in biosynthesis of thyroid hormones. We aimed to identify spectrum mutations TPO gene leading hypothyroidism population West Bengal establish genetic etiology disease. 200 hypothyroid patients (case) and their corresponding sex age matched normal individuals (control) were screened depending on clinical manifestations. Genomic DNA was isolated from peripheral blood samples (Exon 7 Exon 14) amplified by PCR. The PCR products subjected sequencing...
RESULTSThe study comprised 335 participants (69.3% with CKD; 38.5% Chinese, 29.6% Malays, 23.6% Indians, 8.3% others), a mean age of 53.5 ± 15.1 years.Mean standardised serum creatinine was 127 86 µmol/L, while cystatin C and measured GFR were 1.43 0.74 mg/L 67 33 mL/min/1.73m 2 , respectively.The creatinine-cystatin CKD-EPI equation performed the best, an estimated 35 . CONCLUSIONThe new little bias, had increased precision accuracy in our multiethnic Asian population.This two-biomarker may...
Disseminated tuberculosis is a common mode of presentation in patients both with and without HIV/AIDS India. However, primary multidrug resistance disseminated involving only the extrapulmonary sites an immunocompetent adult rare. Here, we report case 19-year-old man who had left pleura, pericardium, peritoneum intraabdominal lymph nodes. He was initially taking WHO category I antituberculous drugs, but not responding spite 5 months chemotherapy. Culture pleural biopsy specimen grew...
Population-based Genome-wide association studies showed variants in KCNJ11 and TCF7L2 genes are associated with type 2 diabetes mellitus (T2DM). Our study was aimed to identify the of common these T2DM related traits West Bengal, India. Six single nucleotide polymorphisms (SNPs) two (KCNJ11- rs5219, rs5215, rs5213, TCF7L2-rs7903146, rs12255372, rs10885409) were genotyped 200 patients ethnically matched normal individuals. Results four SNPs (rs5219, rs7903146, rs12255372) T2DMwhere odd ratios...
Background: As type 2 DM has posed challenging and formidable problem globally lots of scientific research work have been targeted concepts are evolving every other day to unleash newer etiological factor in its causation side by risk factors so that proper aggressive strategy can be instituted contain the disease at very outset.Keeping these ideas back our mind we embarked upon this small but compact path finding study. Methodology:The study conducted Dept. Endocrinology, Medical College...
Liquid chromatography-mass spectrometry, the gold standard method for cortisol measurement, is expensive and not widely available in developing countries. Chemiluminescent immunoassay, commonly used measurement prone to clinically meaningful inter-assay variability some analysers. This occurs due non-specific nature of anticortisol antibodies different platforms, having cross reactivity with structurally similar precursors like 17α-hydroxyprogesterone (17OHP), 11-deoxycortisol...
Aim and Objective: To evaluate the metabolic, hormonal clinical profiles of adolescents young women polycystic ovary syndrome (PCOS). Materials Methods:An Observational cross-sectional study was carried out in department Endocrinology metabolism, Medical College, Kolkata.We included 120 patients PCOS, diagnosed according to Rotterdam criteria 2003, age group 16 40 years.Results: All phenotypes PCOS had higher BMI with respect controls (P<0.05).Among hyperandrogenemic phenotypes, hirsutism...
46, XY difference/disorder of sex development (DSD) is a relatively uncommon group heterogeneous disorders with varying degree underandrogenization male genitalia. Such patients should be approached systematically to reach an aetiological diagnosis. However, we lack, at present, clinical practice guideline on diagnostic approach in DSD from this part the globe. Moreover, debate persists regarding timing and cut-offs different hormonal tests, performed these cases. The consensus committee...
Thyroid diseases pose a substantial socioeconomic burden globally. The aim of this study was to evaluate the correlation between estradiol-to-testosterone (E2/T) ratio and thyroid peroxidase antibody (TPOAb) positivity in male patients with hypothyroidism or euthyroidism.
ABSTRACT Chronic calcific pancreatitis in children is rare, and type 3c diabetes (T3cD) with extensive pancreatic calcification the first decade of life even rarer. We describe a case T3cD an 11-year-old boy who presented hyperglycemic osmotic symptoms. Initial autoantibody testing was positive for high titer, creating diagnostic dilemma. This article examines role autoimmunity pathogenesis post-pancreatitis emphasizes importance performing imaging before, or addition to, carrying out tests,...
A diagnosis of congenital adrenal hyperplasia (CAH) in a '46, XX' newborn with ambiguous genitalia is like 'knee jerk reaction' the paediatrician because its higher frequency and life-threatening consequences if remain undiagnosed hence untreated. Aromatase deficiency (AD), rare cause disorder sex development, mimics virilising CAH many aspects; thus, disease often overlooked. Diagnosis AD women much easier around puberty due to presence primary amenorrhoea, undeveloped breasts, androgen...
Abstract Background One of the common causes suboptimal control thyroid stimulating hormone (TSH) in levothyroxine-treated hypothyroidism is coadministration proton pump inhibitors (PPIs). Morning administration pantoprazole has been shown to suppress intragastric pH a greater extent. We therefore aimed determine effect at different time points day on function test (TFT) overt primary hypothyroidism. Methods In this single centre, hospital based, prospective, two arm cross-over study (AB,...
Idiopathic Hypogonadotropic hypogonadism (IHH) phenotype is variable &various genes have been decribed in association with IHH. We describe of IHH mosaic trisomy 13. A 20 year old male presented lack development secondary sexual characters, normal height, micropenis, small testes, gynaecomastia, absence axillary and pubic hairs, hyposmia, synkinesis, bilateral horizontal nystagmus high arched palate. Investigations showed low gonadotropin, total testosterone, LH after stimulation 100 mcg...
Sir, Endogenous Cushing's syndrome (CS) was diagnosed in a 22-year-old lady with new-onset diabetes mellitus and oligomenorrhea according to the clinical practice guideline of Endocrine Society [Table 1]. She declined bilateral inferior petrosal sinus sampling (BIPSS). Hormonal parameters at her subsequent follow-up (FU) visits have been summarized Table 1. Owing minimal symptoms, she refused both surgery ketoconazole therapy. No endogenous hypercortisolemia could be documented during last...
This prospective single-centred study was conducted on 40 cases and controls randomly selected from the outpatient