Relapsed alcoholic individuals frequently report that negative emotional states trigger their return to drinking. A parametric laboratory study was conducted assess the separate and combined effects of exposure alcohol-related stimuli induced moods in abstinent persons. The authors also sought determine if reactivity alcohol cues or mood induction predicted relapse soon after treatment. Men with alcoholism (N = 50) undergoing inpatient treatment participated a guided imagery procedure...

This study tested the hypothesis that patients could be matched to effective treatments on basis of certain pretreatment characteristics. Specifically, it was hypothesized those Ss who showed more sociopathy, psychopathology, and greater neuropsychological impairment would have better outcomes when treated with coping skills training and, conversely, less in these areas interactional treatment. Ninety-six male female were recruited from an inpatient alcoholism treatment program randomly...

This study compared serotonergic (5-HT) and noradrenergic reactivity in recently detoxified alcoholic patients healthy comparison subjects.Participants were 22 male inpatients who met DSM-III-R criteria for alcohol dependence abstinent 12-26 days 13 subjects. Subjects completed 3 of testing over 2 weeks under double-blind conditions that involved the intravenous infusions m-chlorophenylpiperazine (mCPP), yohimbine, or a saline placebo. Drug effects on mood, physiologic responses, plasma...

Aims. (1) To search for predictors of alcohol craving in treated alcoholics; (2) to evaluate the relationship between and drinking immediately after treatment. Design. Alcoholic patients treatment underwent cue–reactivity trials laboratory then recorded field using hand‐held computers. Laboratory was correlated with field, moods situations were contemporaneous ratings a multi‐level correlational design. Setting. A VA Medical Center substance abuse program provided settings. The patients’...

Ecological Momentary Assessment, a methodology by which information can be obtained about phenomena as they occur in person's natural environment, was used to assess the antecedents relapse treated alcohol abusers. Alcoholic participants (N = 27) were asked record their urge drink and mood state, situation, use on 5- x 7-in. cards response 8 random prompts per day for 21 consecutive days after discharge from Veterans Affairs inpatient treatment center. The purpose of research determine...

Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity) is a multisite collaborative project designed evaluate patient-treatment interactions in alcoholism treatment. To whether major threats the internal validity of independent (treatment) variable could be ruled out, we investigated several aspects treatment integrity and discriminability. In this study, 1,726 alcohol-dependent participants at 10 sites were randomized 3 treatments: cognitive-behavioral (CBT), motivational...

Physiological reactivity and self-reported desire to drink in nonproblem drinkers (N = 11 women 15 men) hospitalized alcoholics 25 34 were examined while subjects held sniffed their preferred alcoholic beverage. Skin conductance level (SCL) heart rate during alcohol exposure significantly higher the than non-alcoholics. Self-reported SCL correlated for but not nonalcoholics. Among alcoholics, change was positively with number of heavy-drinking days month preceding admission treatment....

In the present study 128 alcohol dependent men and women received 26 weeks of group treatment in one two modalities: Cognitive-behavioral (CBT) intended specifically to develop coping skills or interactional therapy examine interpersonal relationships. Coping drinking were assessed prior after up 18 months intake. Results indicated that both treatments yielded very good outcomes throughout follow-up period. Increased was a significant predictor outcome. However, neither effected greater...

<h3>Background</h3> This study evaluated the dose-related ethanol-like subjective effects of the<i>N</i>-methyl-D-aspartate (NMDA) glutamate receptor antagonist ketamine hydrochloride in recently detoxified alcoholics. <h3>Methods</h3> Twenty male inpatients meeting<i>DSM-III-R</i>criteria for alcohol dependence and who had not consumed 10 to 27 days prior completed 3 test that involved intravenous infusion (0.1 mg/kg or 0.5 mg/kg) saline solution under randomized double-blind conditions....

Previous research has shown that a majority of drug-dependent subjects respond to drug cues in the laboratory with increased craving; however, approximately one-third are not cue responsive. The current study examined differences between responders and nonresponders cocaine sample 69 cocaine-dependent methadone patients. Subjects completed questionnaires assessing selected dimensions addiction participated cue-reactivity protocol assessed both craving aversion response cues. Four groups were...

Ninety-six subjects were recruited from an inpatient alcoholism treatment program and randomly assigned to aftercare group with either coping skills training or interactional therapy. Survival analyses using 2-year outcome data provided evidence for the durability of matching interaction effects. The supported a priori hypotheses that individuals scoring high on measures sociopathy global psychopathology have better outcomes in treatment, whereas patients low these dimensions treatment....

Alcohol-tobacco interactions and relapse precipitants were examined among alcohol-dependent smokers in a trial of concurrent alcohol tobacco treatment. After discharge from treatment, participants completed 14 days electronic diary (ED) assessments mood, self-efficacy, urges to drink or smoke, drinking smoking behavior. ED data revealed an increase frequency after episodes. Drinking episodes predicted by prior ratings low self-efficacy resist high urge smoke. Smoking smoke negative, arousal...

OBJECTIVE: This study examined the differential efficacy and relative costs of two intensities adjunctive psychosocial services—a day treatment program enhanced standard care—for opioid-dependent patients maintained on methadone hydrochloride. METHOD: A 12-week randomized clinical trial with 6-month follow-up was conducted in a community-based maintenance program. Of 308 who met inclusion criteria, 291 began (day program: N=145; care: N=146), 237 completed (82% those assigned to 81%...

Background: Many smokers remain refractory to current therapies, which only partially address weight gain after smoking cessation.Thus, this study evaluated whether naltrexone hydrochloride augmentation of nicotine patch therapy improves abstinence and reduces postcessation more than alone at what dose.Methods: Six-week double-blind placebo-controlled trial with follow-up in an outpatient research center.Four hundred individuals who smoked 20 or cigarettes daily were randomly assigned...

The aims of the current study were to examine, prospectively, (a) dynamic changes in affective state, self-efficacy, and urge hours before initial smoking drinking lapses among individuals concurrent alcohol treatment, (b) extent which use, and/or use one substance predicted lapse other substance. Ninety-six men women recruited for a clinical trial tobacco treatment eligible inclusion. Only data from those who experienced an (n=29) or (n=32) included. Two outpatient abuse clinics provided on...