A5080711001- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Frailty in Older Adults
- Hemodynamic Monitoring and Therapy
Erasmus University Rotterdam
2015-2020
Erasmus MC
2015-2019
Rigshospitalet
2018
Antwerp University Hospital
2018
Ghent University
2018
Background— The extent to which pressure generated by the valve on aortic root plays a role in genesis of conduction abnormalities after transcatheter replacement (TAVR) is unknown. This study elucidates contact and area development TAVR using patient-specific computer simulations. Methods Results— Finite-element simulations were performed simulate 112 patients who had undergone with self-expanding CoreValve/Evolut R valve. On basis preoperative multi-slice computed tomography, region...
Aims: Our aim was to validate patient-specific software integrating baseline anatomy and biomechanical properties of both the aortic root valve for prediction morphology leaflet calcium displacement after TAVI.Methods results: Finite element computer modelling performed in 39 patients treated with a Medtronic CoreValve System (MCS; n=33) or an Edwards SAPIEN XT (ESV; n=6).Quantitative axial frame at inflow (MCS, ESV) nadir, coaptation commissures (MCS) compared between multislice computed...
Background: A patient-specific computer simulation of transcatheter aortic valve replacement (TAVR) in tricuspid has been developed, which can predict paravalvular regurgitation and conduction disturbance. We wished to validate a TAVR bicuspid determine whether heart (THV) sizing positioning might improve clinical outcomes. Methods: retrospective study was performed on patients that had both pre- postprocedural computed tomography imaging. Preprocedural imaging used create finite element...
We describe a new semi-automated method that measures aortic regurgitation (AR) on contrast aortography with the objectives of reducing inter-observer variability and standardising image acquisition.Aortograms from three participating centres were reviewed to generate following quality criteria: entire left ventricle root in view, descending aorta or TOE probe not over-projected, breath hold, no table motion, adequate opacification root. AR was visually graded (Sellers) quantified by...
The Lotus and SAPIEN3 are second-generation transcatheter heart valves, which designed to minimize paravalvular aortic regurgitation (PAR) after valve replacement (TAVR). We sought compare both devices for performance with emphasis on PAR by independent core laboratory analysis.A total of 162 (79 83 SAPIEN3) consecutive patients (51% female, 80 ± 8 years, Logistic EuroSCORE 14.8 9.4%) who underwent TAVR because stenosis were included. Patients valve-in-valve treatment excluded. Pre-discharge...
Background: We aimed to compare the rate of neurological events in patients with or without cerebral embolic protection (CEP) during transcatheter aortic valve replacement (TAVR). Methods and Results: Data on clinical end points including ≤30 days post-TAVR were collected for all who underwent transfemoral TAVR 2 academic tertiary care institutions. Patients matched through propensity scoring, which resulted 333 pairs versus CEP out a total 831 consecutive patients. The median age was 81...
To correlate dynamics in electrical conduction after transcatheter aortic valve implantation (TAVI) with need for permanent pacemaker (PPM) and assess implications early discharge.Daily electrocardiograms TAVI were analysed rhythm times correlated PPM. Transcatheter was performed 291 consecutive patients three contemporary heart designs: Medtronic CoreValve (n = 111), Edwards Sapien XT 29) 3 72), Boston Lotus 79). We considered two cohorts: (A) Patients normal baseline conduction; (B)...
Aortic regurgitation (AR) after Medtronic CoreValve System (MCS) implantation may be explained by patient-, operator- and procedure-related factors. We sought to explore if frame geometry, as a result of specific device-host interaction, contributes AR.Using rotational angiography with dedicated motion compensation, we assessed valve geometry in 84 patients who underwent TAVI the MCS. was (n=84, Sellers) echocardiography at discharge (n=72, VARC-2). Twenty-two (26%) had AR grade ≥2 using...
Abstract Valve size selection for transcatheter aortic valve replacement (TAVR) is currently based on cardiac CT-scan. At variance with patient-specific computer simulation, this does not allow the assessment of valve-host interaction. We aimed to compare clinical and by an independent expert simulation. A multicenter retrospective analysis physician in 141 patients who underwent TAVR self-expanding CoreValve or Evolut R. Baseline CT-scan was used Simulation results were available use....
Dedicated data on the prevalence of incidental findings (IF) stratified according to overall clinical relevance and their subsequent correlation outcome are lacking. The aim present study was describe consequences noncardiac IF computed tomography or magnetic resonance imaging in workup for interventional cardiovascular procedures.A total 916 patients underwent preprocedural transcatheter aortic valve implantation (TAVI), renal sympathetic denervation (RDN), MitraClip implantation.IF were...
We aimed to compare conduction dynamics and need for permanent pacemaker implantation (PPI) after CoreValve, Evolut R PRO (transcatheter aortic valve replacement (TAVR)). Patients were stratified based on at baseline; Cohort A had normal conduction, B abnormalities including atrioventricular (AV)-block, fascicular block or complete bundle branch block. Three different dynamic QRS-patterns defined: stable QRS-duration, transient QRS-prolongation persistent QRS-prolongation. performed...
Transcatheter aortic valve implantation (TAVI) has become the standard treatment for patients with severe symptomatic stenosis (AS) considered at very high risk surgical replacement. The purpose of this sub-study was to evaluate long-term (> 4 years) health-related quality life (QoL) in octogenarians who underwent TAVI.A single center observational registry twenty frame analysis assessment ≥ years after TAVI. Health-related QoL evaluated, using Short Form-36 (SF-36), EuroQoL-5D (EQ-5D) and...