A5060445377- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- HIV/AIDS drug development and treatment
- LGBTQ Health, Identity, and Policy
- Adolescent and Pediatric Healthcare
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Homelessness and Social Issues
- Hepatitis C virus research
- HIV/AIDS Impact and Responses
- Sex work and related issues
- Mental Health Treatment and Access
- Child Abuse and Trauma
- Migration, Health and Trauma
- Syphilis Diagnosis and Treatment
- Opioid Use Disorder Treatment
- Racial and Ethnic Identity Research
- Hepatitis B Virus Studies
- Prenatal Substance Exposure Effects
Fred Hutch Cancer Center
2015-2024
Seattle University
2024
University of Washington
2023
John H. Stroger, Jr. Hospital of Cook County
2023
University of Colorado Anschutz Medical Campus
2023
Family Health International 360
2018-2023
University of Zimbabwe
2023
University of Cape Town
2023
University of the Witwatersrand
2023
Cancer Research Center
2015-2020
Achieving linkage to care and viral suppression in human immunodeficiency virus (HIV)-positive patients improves their well-being prevents new infections. Current gaps the HIV continuum substantially limit such benefits.To evaluate effectiveness of financial incentives on HIV-positive patients.A large community-based clinical trial that randomized 37 test 39 sites Bronx, New York, Washington, DC, or standard care.Participants at incentive who had positive results for received coupons...
Abstract Introduction Randomized clinical trials have demonstrated the efficacy of antiretroviral pre‐exposure prophylaxis (Pr EP ) in preventing HIV acquisition among men who sex with ( MSM ). However, limited research has examined initiation and adherence to Pr Black BMSM United States US are disproportionately represented newly infected late care individuals. This reports on Prevention Trials Network 073 HPTN 073) study aimed examine initiation, utilization utilizing theoretically...
Background: The Russian HIV-1 epidemic has been driven by injection drug use. Objective: To determine HIV incidence and identify demographic behavioral correlates of infection to facilitate the development longitudinal prevention programs. Methods: In 2002, a cohort 520 users (IDU) in St Petersburg, Russia were recruited tested counseled for HIV-1. HIV-seronegative IDU enrolled reevaluated at 6 12 months. testing was performed sociodemographic data collected during each study visit....
Pre-exposure prophylaxis (PrEP) is efficacious for HIV prevention. Black men who have sex with (MSM) accounted the largest proportion of new diagnoses in United States relative to other racial/ethnic groups. MSM use substances are at an increased risk infection and ideal candidates PrEP, but barriers maintaining PrEP adherence remain a concern. We assessed whether substance behaviors associated initiation among sample black States.Data this analysis come from Prevention Trails Network Study...
Background Cross-sectional assessment of HIV incidence relies on laboratory methods to discriminate between recent and non-recent infection. Because diversifies over time in infected individuals, diversity may serve as a biomarker for assessing incidence. We used high resolution melting (HRM) assay compare adults with different stages This provides single numeric HRM score that reflects the level genetic sample from an individual. Methods was measured 203 adults: 20 acute infection (RNA...
Background: Injection opioid use plays a significant role in the transmission of HIV infection many communities and several regions world. Access to evidence-based treatments for disorders is extremely limited. Methods: Prevention Trials Network 058 (HPTN 058) was randomized controlled trial designed compare impact 2 medication-assisted treatment (MAT) strategies on incidence or death among opioid-dependent people who inject drugs (PWID). HIV-negative PWID were recruited from 4 Thailand...
Abstract Background The HIV Prevention Trials Network (HPTN) Study 073 (HPTN 073) assessed the feasibility, acceptability, and safety of preexposure prophylaxis (PrEP) for black men who have sex with (BMSM). purpose this analysis was to characterize relationship between PrEP uptake use incident sexually transmitted infections (STIs) among participants enrolled in HPTN 073. Methods A total 226 human immunodeficiency virus (HIV)–uninfected BMSM were 3 US cities; all received client-centered...
ObjectiveTo determine HIV seroincidence, study participant retention rate, and baseline predictors of incidence among high-risk injection drug users (IDUs) in Xinjiang, China.MethodsA total 508 eligible seronegative IDUs were enrolled. Study participants tested for HIV-1 counseled at the baseline, 6-month, 12-month follow-up visits. Sociodemographic behavioral data collected during each visit. The rate analyzed as a function sociodemographic, behavioral, recruitment variables.ResultsAt 12...
Background: Use of antiretroviral therapy (ART) to prevent HIV transmission has received substantial attention after a recent trial demonstrating efficacy ART reduce in HIV-discordant couples. Objective: To assess practices and attitudes clinicians regarding early initiation for treatment prevention at sites participating the Prevention Trials Network 065 study. Design: Cross-sectional internet-based survey. Methods: ART-prescribing (n = 165 physicians, nurse practitioners, physician...
The sub-population at greatest risk for HIV infection in the United States is Black men who have sex with (BMSM), and there an urgent need effective prevention interventions among them 1. Despite advances biomedical behavioural interventions, healthcare systems continue to fail slow epidemic BMSM. This particularly case young 2, estimated lifetime of up 50% 3. It has been well demonstrated that tenfovir disiproxil fumarate (TDF) emtricitabine (FTC) as pre-exposure prophylaxis (PrEP) are...
Trust is an important cornerstone of patient-provider communication. Accurate reporting pre-exposure prophylaxis (PrEP) adherence vital for providers to determine who needs support, especially adolescent girls and young women (AGYW) disproportionately affected by newly diagnosed HIV.
ABSTRACT Aims To determine the HIV‐1 seroprevalence, risk behaviors and demographic characteristics associated with infection among injection drug users (IDU) in rural Guangxi, China. Design setting Between July November 2002, 702 IDU were screened for antibody through community outreach China enrollment an HIV sero‐incidence study. Participants A total of active high‐risk screened. High‐risk was defined as anyone who reported injecting drugs at least three times per week last month or...
Abstract To develop effective PrEP adherence interventions, it is important to understand the interplay between disclosure of pre-exposure prophalxis (PrEP) use, social support, and adherence. We leveraged HPTN 082 study conducted among 451 adolescent girls young women (AGYW) (ages 16 25 years, 2016 2019) in South Africa Zimbabwe. Among 349 who had month three data, 60% (n = 206) felt supported by adults, 89% 309) disclosed use at least one person. was not associated with increased...
Abstract Background: A prospective observational study of HIV seroincidence among high-risk injection drug users (IDU) was carried out in Guangxi, China. The primary objectives this were (1) to estimate seroincidence, (2) participant retention rate, and (3) evaluate changes use sexual behavior over a one year period. Methods: Five hundred seronegative IDU enrolled. HIV-1 incidence rates analyzed as function sociodemographic, behavioral, recruitment variables. Changes at the baseline, 6-monfh...
Modeling studies suggest intensified HIV testing, linkage-to-care and antiretroviral treatment to achieve viral suppression may reduce transmission lead control of the epidemic. To study implementation strategy, population-level data are needed monitor outcomes these interventions. US surveillance systems a potential source data.HPTN065 (TLC-Plus) Study is evaluating feasibility test, linkage-to-care, treat strategy for prevention in two intervention communities - Bronx, NY, Washington, DC....
Daily oral tenofovir disoproxil fumarate (TDF)-emtricitabine (FTC) is a safe and effective intervention for HIV preexposure prophylaxis (PrEP). We evaluated the performance of qualitative assay that detects 20 antiretroviral (ARV) drugs (multidrug assay) in assessing recent PrEP exposure (detection limit, 2 to ng/ml). Samples were obtained from 216 Black men who have sex with (208 HIV-uninfected 8 seroconverters) enrolled study United States evaluating acceptability TDF-FTC (165 uninfected 5...
While HIV infections among men who have sex (MSM) started to decline in the United States, Black MSM continue experience disproportionate rates of infection. The purpose this secondary analysis is examine risk perception and its influence on PrEP adherence from HPTN 073. Risk was measured using adapted Perceived Vulnerability Scale. associations between were tested generalized estimation equation model for time-variant repeated measures. not significantly associated with adherence. These...