A5036935237- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Curcumin's Biomedical Applications
- S100 Proteins and Annexins
- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- Medicinal Plants and Neuroprotection
Western Sydney University
2019-2021
Stockholm University
2014-2015
Chronic microglial activation is a prominent feature of many chronic neurodegenerative diseases, including Parkinson's and Alzheimer's disease. To investigate the effects on cerebellar structure motor function throughout lifespan, transgenic GFAP-IL6 mouse model was used. The aim study to examine inflammatory markers neuronal degeneration while simultaneously characterizing performance mice at 3, 6, 14 24 months age in comparison WT (C57BL/6) mice. In respect neuroinflammation cerebellum,...
Abstract Chronic glial activation is characterized by increased numbers of activated cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity Longvida ® Optimised Curcumin (LC), we fed 500 ppm LC 2-month-old wild type GFAP-IL6 mice for 6 months. feeding led a significant reduction in number Iba-1 + microglia 26% hippocampus 48% cerebellum, GFAP astrocytes 30%, TSPO cells 24% 31% cerebellum mice. The...
Chronic neuroinflammation is a promising therapeutic target in many neurodegenerative and age‐related brain disorders. In this study, we investigated two highly bioavailable curcumin preparations, Longvida (LC) Meriva (MC) for their anti‐inflammatory properties, using the GFAP‐IL6 mouse model. We hypothesized that curcumin, as potent cytokine‐suppressive drug, will decrease microglial astroglial activation measured by cell number morphology, consequently improve motor cognitive functions....