A5087685666- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Curcumin's Biomedical Applications
- Stress Responses and Cortisol
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Vagus Nerve Stimulation Research
- Flavonoids in Medical Research
- Olfactory and Sensory Function Studies
- Advanced Neuroimaging Techniques and Applications
- Vitamin D Research Studies
- Biochemical effects in animals
- Medicinal Plants and Neuroprotection
- Advanced NMR Techniques and Applications
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Advanced Glycation End Products research
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Medicinal Plants and Bioactive Compounds
Camden and Campbelltown Hospitals
2013-2023
Western Sydney University
2013-2023
Vitamin D deficiency is widespread, affecting over 30% of adult Australians, and increasing up to 80% for at-risk groups including the elderly (age>65). The role in development central nervous system supported by association between incidence neurological psychiatric disorders Alzheimer's disease (AD). A reported positive relationship status cognitive performance suggests that restoring might provide a benefit those with deficiency. Mushrooms are rich source ergosterol, which can be...
Chronic microglial activation is a prominent feature of many chronic neurodegenerative diseases, including Parkinson's and Alzheimer's disease. To investigate the effects on cerebellar structure motor function throughout lifespan, transgenic GFAP-IL6 mouse model was used. The aim study to examine inflammatory markers neuronal degeneration while simultaneously characterizing performance mice at 3, 6, 14 24 months age in comparison WT (C57BL/6) mice. In respect neuroinflammation cerebellum,...
Chronic neuroinflammation characterized by microglia reactivity is one of the main underlying processes in initiation and progression neurodegenerative diseases such as Alzheimer’s disease. This project spatial memory during healthy aging prolonged chronic neuroinflammatory model, glial fibrillary acidic protein-interleukin 6 (GFAP-IL6). We investigated whether treatment with natural flavonoid, apigenin, could reduce activation hippocampus improve memory. GFAP-IL6 transgenic wild-type-like...
Chronic glial activation is characterized by an increased number of activated microglia and astroglia; these secrete free radicals cytotoxic cytokines, subsequently causing neuronal damage. This study investigated the hypothesis that a soy-lecithin based phytosomal curcumin formulation can decrease in brains GFAP-IL6 mice, model chronic activation, which exhibits gliosis various regions brain. Three doses Meriva (MC) (874, 436, 218 PPM) were fed to 3-month-old wild-type (WT) mice for 4...
Abstract Chronic glial activation is characterized by increased numbers of activated cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity Longvida ® Optimised Curcumin (LC), we fed 500 ppm LC 2-month-old wild type GFAP-IL6 mice for 6 months. feeding led a significant reduction in number Iba-1 + microglia 26% hippocampus 48% cerebellum, GFAP astrocytes 30%, TSPO cells 24% 31% cerebellum mice. The...
BACKGROUND Leukoaraiosis is characterized by white matter lesions (WMLs) on magnetic resonance imaging (MRI) and associated with cognitive impairment. The small-world network viewed as the optimal brain maximal efficiency in information processing. Patients impairment are thought to have disrupted networks. In this study, we compared attributes between controls (study participants without memory complaints) patients WMLs MATERIAL AND METHODS All study were prescreened using MRI...
Low-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of major hallmarks for aging-related neurodegenerative diseases like Alzheimer's disease (AD). The basal forebrain cholinergic neurons (BFCN) provide primary source innervation human cerebral cortex and may be differentially vulnerable various diseases. However, impact neuroinflammation on function still unclear.To gain further insight into age-related decline, we investigated cumulative...
Neuroinflammation is a common feature of many psychiatric disorders as well underlying mechanism neurodegenerative diseases. Sex has been shown to strongly influence the development clinical expression these pathologies. However, there still neglect regarding consideration sex effects in rodent experiments, and substantial underrepresentation females studies. This work set out expand our knowledge neuroinflammatory mechanisms female mice, at both behavioral molecular level.This study used...
Abstract Background Neuroinflammation, described by chronic glial reactivation lead to gradual neurodegeneration during pathological aging, contributing disorders like Alzheimer’s disease (AD). Cholinergic cell loss in the basal forebrain (BF) including medial septum (MS) is associated with AD; however underlying mechanism still unknown. Hence, this study investigated effects of aging and neuroinflammation on MS cholinergic numbers morphology. Method Aged, 12 24 months WT GFAP‐IL6 mice...
Chronic neuroinflammation is a promising therapeutic target in many neurodegenerative and age‐related brain disorders. In this study, we investigated two highly bioavailable curcumin preparations, Longvida (LC) Meriva (MC) for their anti‐inflammatory properties, using the GFAP‐IL6 mouse model. We hypothesized that curcumin, as potent cytokine‐suppressive drug, will decrease microglial astroglial activation measured by cell number morphology, consequently improve motor cognitive functions....
Abstract Background Chronic neuroinflammation has been identified as a common feature of many neurodegenerative diseases, such Alzheimer’s disease (Kempuraj et al., 2016). Sex shown to strongly influence the development well clinical expression and neuroinflammatory diseases . The GFAP‐IL6 mouse is useful model study chronic its consequences. These mice exhibit increased levels markers, neurodegeneration, motor deficits (Campbell 1993; Chiang 1994; Gyengesi 2019). Although previous studies...
Understanding the role of chronic neuroinflammation, described by increased astro- and microglia activation, in pathogenesis Alzheimer's disease (AD) is becoming crucial due to its throughout progression (Deczkowska et al., 2018). In search a suitable mouse model glial we characterized GFAP-IL6 transgenic which pro-inflammatory cytokine interleukine-6 overexpressed under control fibrillary acidic protein (GFAP) promoter (Campbell 1993). The mice display inflammatory conditions brain, with...