A5047180707- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Digital Radiography and Breast Imaging
- Advanced MRI Techniques and Applications
- Radiation Therapy and Dosimetry
- Atomic and Subatomic Physics Research
- Radiomics and Machine Learning in Medical Imaging
- Particle Detector Development and Performance
- Advanced X-ray and CT Imaging
- Nuclear Physics and Applications
- Radiopharmaceutical Chemistry and Applications
- Advanced NMR Techniques and Applications
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Lung Cancer Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Esophageal Cancer Research and Treatment
- MRI in cancer diagnosis
- Particle Accelerators and Free-Electron Lasers
- Radioactive Decay and Measurement Techniques
- Electron Spin Resonance Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Medical Imaging and Pathology Studies
West Virginia University
2014-2024
Motion Control (United States)
2013
Advanced Imaging Research (United States)
2008
University of Michigan–Ann Arbor
1986-1997
Tomographic breast imaging techniques can potentially improve detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. We have developed a high-resolution positron emission mammography/tomography biopsy device (called PEM/PET) to detect guide the suspicious lesions. PET images are acquired focal uptake radiotracer area. Limited-angle PEM could then be used verify needle position prior tissue sampling. The PEM/PET scanner consists two sets rotating planar...
Proposals to enhance the amount of radiation dose delivered small tumors with radioimmunotherapy by constraining emitted electrons very strong homogeneous static magnetic fields has renewed interest in cellular effects prolonged exposures such fields. Past investigations have not studied on tumor cell growth lengthy high Three malignant human lines, HTB 63 (melanoma), 77 IP3 (ovarian carcinoma), and CCL 86 (lymphoma; Raji cells), were exposed a 7 Tesla uniform field for 64 hours. Following...
Inflammation contributes to atherosclerotic plaque remodeling, enlargement and rupture. Non-invasive imaging of coronary artery inflammation could help target therapy 'vulnerable' atheromata, but is limited because small tissue mass arterial motion. Local radiopharmaceutical may overcome some these limitations. We used a positron-sensitive fiberoptic probe, which can distinguish positron emissions from annihilation photons, identify diseased healthy endothelium in an model. New Zealand White...
Multi-modality imaging is rapidly becoming a valuable tool in the diagnosis of disease and development new drugs. Functional images produced with PET fused anatomical structure created by MRI will allow correlation form function. Our group developing system to acquire contemporaneously. The prototype device consists two opposed detector heads, operating coincidence mode. Each MRI–PET module an array LSO elements coupled through long fibre optic light guide single Hamamatsu flat panel...
Abstract Background Positron Emission Tomography ( PET ) is traditionally used to image patients in restrictive positions, with few devices allowing for upright, brain‐dedicated imaging. Our team has explored the concept of wearable imagers which could provide functional brain imaging freely moving subjects. To test feasibility and determine future considerations development, we built a rudimentary proof‐of‐concept prototype (Helmet_ conducted tests phantoms four human volunteers. Methods...
Abstract Objective: In the past several decades, numerous PET scanners of various designs have been constructed for use in pre-clinical studies. Our group is investigating a monolithic annulus scintillator, instead traditional arrays discrete scintillator elements or individual detectors that utilize continuous blocks to construct novel scanner. 

Approach: This scanner, called AnnPET, based on fourteen-faceted LYSO with an inner diameter 6 cm and length 7.2 cm. Each facet...
Positron emission tomography (PET) relies upon the detection of photons resulting from annihilation positrons emitted by a radiopharmaceutical. The combination images obtained with PET and magnetic resonance imaging (MRI) have begun to greatly enhance study many physiological processes. A combined MRI-PET scanner could alleviate much spatial temporal coregistration difficulties currently encountered in utilizing these complementary modalities. In addition, resolution be improved effects...
We measured the analyzing power $A$ and spin-spin correlation parameter ${A}_{\mathrm{nn}}$, in large-${P}_{\ensuremath{\perp}}^{2}$ proton-proton elastic scattering, using a polarized-proton target beam at Brookhaven Alternating-Gradient Synchrotron. also used our polarimeter to measure small ${P}_{\ensuremath{\perp}}^{2}$ 13 GeV with good precision found some deviation from expected $\frac{1}{{P}_{\mathrm{lab}}}$ behavior. At 18.5 GeV/c we...
Abstract Fentanyl exposure and overdose are growing concerns in public health occupational safety. This study aimed to establish parameters of fentanyl lethality SKH1 mice for future research. Lethality was determined using the up‐down procedure, with subjects monitored post‐administration pulse oximetry (5 min) then whole‐body plethysmography (40 min). Following determination subcutaneous dose–response, [18F]Fluorodeoxyglucose positron emission tomography ( 18 F‐FDG PET) performed after...
Accelerating polarized protons to 22 GeV/c at the Brookhaven Alternating Gradient Synchro- tron required both extensive hardware modifications and a difficult commissioning process. We had overcome 45 strong depolarizing resonances maintain polarization up in this strong-focusing synchrotron. At 18.5 we measured analyzing power A spin-spin correlation parameter Ann large- P2⊥ proton-proton elastic scattering, using proton beam target. also obtained high-precision measurement of P2⊥=0.3...
Positron emission mammography (PEM) is a new, specialized imaging modality utilizing PET radiopharmaceuticals to detect breast cancer. The capabilities and limitations of PEM in detecting tumors were investigated with series phantom experiments. imager was mounted on standard Lorad biopsy table (separated by 18 cm). In the initial phase investigation, basic scanner parameters (resolution, sensitivity, scatter fraction) measured. effects number (length acquisition, thickness, density)...
Positron emission mammography (PEM) with tomographic acquisition using dual planar detectors rotating about the breast can obtain complete angular sampling and has potential to improve activity estimation compared PEM stationary detectors. tomography (PEMT) was for point source compressed phantom studies performed a compact detector system. The geometries were appropriate target application of guidance stereotactic core biopsy. Images reconstructed three-dimensional iterative maximum...
The link between body weight, lipid metabolism, and health risks is poorly understood difficult to study. Magnetic resonance spectroscopy (MRS) permits noninvasive investigation of metabolism. We extended existing two-dimensional MRS techniques permit quantification intra- extramyocellular (IMCL EMCL, respectively) compartments their degree unsaturation in human subjects correlated these results with mass index (BMI). Using muscle creatine for normalization, we observed a statistically...
Recent advances in the development of silicon photomultipliers (SiPM) offer new opportunities for medical imaging applications. Specifically, novel devices positron emission (PET) and single photo-emission computed tomography (SPECT) are becoming feasible. In this investigation, we tested a monolithic array generation SiPMs, an SB-8 from SensL. 8×8 6-mm square SiPMs was studied with two different multiplexing readouts, 4- 16-channels. detector coupled to various scintillation arrays...
Abstract Purpose To demonstrate the feasibility of estimating relative intra‐ and extramyocellular lipid (IMCL EMCL) pool magnitudes calculating degree unsaturation within soleus muscle using single‐voxel localized one‐ two‐dimensional (1D 2D) MR spectroscopy (MRS). Materials Methods Localized 1D point resolved (PRESS) 2D correlation (L‐COSY) were performed in identical locations 10 healthy subjects. A GE 3‐T MRI/MRS scanner a quadrature extremity transmit/receive coil was used. Results The...
A new flexible data acquisition system has been developed to instrument gamma-ray imaging detectors designed by the Jefferson Lab Detector and Imaging Group. Hardware consists of 16-channel modules installed on USB2 carrier boards. Carriers have accept one, two, four modules. Application trigger rate channel density determines number boards readout computers used. Each an independent trigger, gated integrator a 2.5 MHz 12-bit ADC. module FPGA for analog control signal processing. Processing...