A5060486728- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Atomic and Subatomic Physics Research
- Advanced X-ray and CT Imaging
- Particle Detector Development and Performance
- Stroke Rehabilitation and Recovery
- Digital Radiography and Breast Imaging
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- E-Learning and Knowledge Management
- Peptidase Inhibition and Analysis
- Muscle activation and electromyography studies
- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Signaling Pathways in Disease
- EEG and Brain-Computer Interfaces
- Hand Gesture Recognition Systems
- Problem and Project Based Learning
- Radiation Therapy and Dosimetry
- Innovative Teaching and Learning Methods
West Virginia University
2012-2025
Purdue University West Lafayette
2022
University of Naples Federico II
1998
Abstract Background Positron Emission Tomography ( PET ) is traditionally used to image patients in restrictive positions, with few devices allowing for upright, brain‐dedicated imaging. Our team has explored the concept of wearable imagers which could provide functional brain imaging freely moving subjects. To test feasibility and determine future considerations development, we built a rudimentary proof‐of‐concept prototype (Helmet_ conducted tests phantoms four human volunteers. Methods...
Abstract Objective: In the past several decades, numerous PET scanners of various designs have been constructed for use in pre-clinical studies. Our group is investigating a monolithic annulus scintillator, instead traditional arrays discrete scintillator elements or individual detectors that utilize continuous blocks to construct novel scanner. 

Approach: This scanner, called AnnPET, based on fourteen-faceted LYSO with an inner diameter 6 cm and length 7.2 cm. Each facet...
Fibroblast activation protein (FAP) has received increasing attention as an oncologic target because of its prominent expression in solid tumors but virtual absence from healthy tissues. Most radioligand therapies (RLTs) targeting FAP, however, suffer inadequate tumor retention or clearance Herein we report a FAP-targeted RLT comprising FAP6 ligand conjugated to DOTA and albumin binder (4-<i>p</i>-iodophenylbutyric acid, IP) for enhanced pharmacokinetics. We evaluated the performance...
PET scanners based on monolithic pieces of scintillator can potentially produce superior performance characteristics (high spatial resolution and detection sensitivity, for example) compared to conventional scanners. Consequently, we initiated development a preclinical system single 7.2 cm long annulus LYSO, called AnnPET. While this could facilitate creation high-quality images, its unique geometry results in optics that complicate estimation event positioning the detector. To address...
Application of advanced imaging techniques, such as PET and x ray CT, can potentially improve detection breast cancer. Unfortunately, both modalities have challenges in the some lesions. The combination two however, could lead to an overall improvement diagnostic imaging. purpose this investigation is test basic performance a new dedicated breast-PET/CT.The component consists rotating pair detectors. Its was evaluated using NEMA NU4-2008 protocols. CT utilizes pulsed source flat panel...
Positron emission tomography (PET) scanners designed for imaging of small animals have transformed translational research by reducing the necessity to invasively monitor physiology and disease progression. Virtually all these are based on use pixelated detector modules arranged in rings. This design, while generally successful, has some limitations. Specifically, discrete construct PET reduces detection sensitivity can introduce artifacts reconstructed images, requiring correction methods....
The Multimodal Imaging of Neurological Disorders (MINDview) project aims to develop a high resolution and sensitivity dedicated brain Positron Emission Tomography (PET) system capable visualizing neurotransmitter pathways their disruptions for mental disorders diagnosis treatment follow-up. Moreover, this compact PET should be fully compatible with Magnetic Resonance (MRI) in order allow its operation as insert hybrid imaging setup most MRI scanners. proposed design will enable current...
Our research group constructed a 12-module PET detection ring composed of Hamamatsu multi-pixel photon counter (MMPC) silicon photomultiplier (SiPM) detectors placed in that is fully MRI compatible. This brain imager can be around the head patient (clinical setting) or subject (research and allow for comfortable upright imaging. However, an alternative way to use this device, as enabled by technology, indeed scan individuals supine position conjuncture with current systems. prototype able...
Development of advanced preclinical imaging techniques has had an important impact on the field biomedical research, with positron emission tomography (PET) most mature these efforts. Developers PET scanners have joined recent multimodality trend by combining other modalities, such as magnetic resonance (MRI). Our group developed a combined PET-MRI insert for animals up to size rats in clinical 3T MRI scanner. The system utilizes sequential scanner configuration instead more common coplanar...
Mice are the perhaps most common species of rodents used in biomedical research, but many current generation small animal PET scanners non-optimal for imaging these due to their relatively low resolution. Consequently, a number researchers have investigated development high-resolution address this need. In investigation, design novel, system based on dual-detector, virtual-pinhole concept was explored via Monte Carlo simulations. Specifically, system, called TandemPET, consists 5 cm ×...
We are developing a dedicated high resolution (sub-mm), efficiency, and very fast (with live reconstruction) prostate PET imager composed of an endorectal probe two panel modules placed close to the patient on opposite side prostate, operating in coincidence with probe. The immediate image feedback will be primarily useful biopsy guidance. images co-registered from Transrectal Ultrasound (TRUS) that provide usual structural 2D or 3D information, while metabolic information related biological...
Large arrays of pixelated scintillator potentially have application in economical construction PET scanners. In this investigation, we constructed and evaluated a detector with an active area 32.26 × 13.47 cm2. It is based on 218 91 array 1.4 15 mm3 LYSO elements (pitch 1.48 mm). Scintillation light detected 5 12 silicon photomultipliers (SiPM) arrays. Each consists 8 3 mm2 3.35 mm) SiPMs. Performance these devices are enhanced stabilized by cooling them. Testing revealed that the was able...
Staging of head and neck cancer (HNC) is often hindered by the limited resolution standard whole body PET scanners, which can make it challenging to detect small areas metastatic disease in regional lymph nodes accurately delineate tumor boundaries. In this investigation, performance a proposed high PET/CT scanner designed specifically for imaging region was explored. The goal create dedicated system that will enhance staging treatment HNCs. Its assessed simulating scanning three-dimensional...