Abstract Introduction Pediatric thermal injury induces a heightened inflammatory response and immune dysfunction, which is associated with adverse clinical outcomes (e.g., infections). Specifically, burns ≥20% total body surface area or ≥5% full thickness in pediatric patients, results suppression are most at risk to develop subsequent infections. As such, immunomodulating therapeutics have been of great interest augment the following injury. Our hypothesis was that after reversible ex-vivo...

Abstract Background The study of localized immune-related factors has proven beneficial for a variety conditions, and one area interest in the field orthopaedics is impact implants infections on immune response. Several cytokines have shown increased systemic concentrations (in serum/plasma) response to infection, but tissue-level not been investigated as thoroughly. Methods This exploratory cohort patients (N = 17) total knee arthroplasty revision better understand infection (e.g.,...

Thermal injury induces concurrent inflammatory and immune dysfunction, which is associated with adverse clinical outcomes. However, these effects in the pediatric population are less studied there no standard method to identify those at risk for developing infections. Our goal was better understand dysfunction soluble protein markers following thermal injury. Further we wanted determine early inflammatory, soluble, or function most predictive of development nosocomial infections (NI) after...

Abstract Thermal injury results in changes the inflammatory and innate immune response of pediatric patients. Plasma cytokines, cellular profiles, reduction function following burn have also been correlated to adverse outcomes (e.g., mortality infectious complications). Changes adaptive thermal are not as well characterized. Our goal was better understand if dysfunction occurs early after is a risk factor for nosocomial infections (NIs). A prospective, longitudinal observational study...

Background: There is currently no standard definition of a severe burn in the pediatric patient population to identify those at higher risk infectious complications. Our aim was correlate total surface area (TBSA), depth, and type injury nosocomial infection rates systemic immune system responses better define factors associated with adverse outcomes. Methods: A prospective observational study single-center, quaternary-care, American Burn Association-verified center conducted from 2016 2021....

Background: Thermal injury is a major cause of morbidity and mortality in the pediatric population worldwide with secondary infection being most common acute complication. Suppression innate adaptive immune function predictive burn patients, but little known about mechanisms causing these effects. Circulating mitochondrial DNA (mtDNA), which induces proinflammatory signal, has been described multiple disease states not studied injuries. This study examined quantity circulating mtDNA...

Systemic cytokine concentrations have been extensively studied in implant-associated infections, providing sensitive diagnostic markers. However, less is known about the relationships of tissue-level cytokines surrounding joint. The aim this study was to define profiles tissues investigate use these as markers debridement chronic joint infection. Using a rodent model, muscle samples were obtained from rats following Kirschner wire implantation and infection with Staphylococcus aureus...

Abstract Pediatric burn injuries are a leading cause of morbidity with infections being the most common acute complication. Thermal elicit heightened cytokine response while suppressing immune function; however, mechanisms to this dysfunction still unknown. Our aim was identify extracellular proteins and circulating phosphoprotein expression in plasma after injury predict development nosocomial infection (NI). Plasma collected within 72 hours from 64 pediatric subjects; these, 18 went on...

The early cellular response to infection has been investigated extensively, generating valuable information regarding the mediators of acute response. Various cytokines have highlighted for their critical roles, and actions these are related intracellular phosphorylation changes promote resolution. However, development chronic infections not thoroughly investigated. While it is known that wound healing processes disrupted, interactions phosphoproteins contribute this dysregulation well...

Using salivary inflammatory markers as a noninvasive biomonitoring technique within natural social contexts has become increasingly important to link and biological responses. Many studies have associated circulating cytokines distinct aspects of physical activity social/emotional behavior; however, they not been linked success failure in naturalistic setting for military personnel performing tasks. In this study, were studied group fifteen Air Force Reserve Officers' Training Corps (ROTC;...

AimsVeterans from the 1990–91 Gulf War were exposed to acetylcholinesterase inhibitors (AChEIs), and, following service, an estimated one-third began suffering a medically unexplained, multi-symptom illness termed Illness (GWI). Previous research has developed validated rodent models that include exposure exogenous corticosterone (CORT) and AChEIs simulate high stress chemical exposures encountered in theater. This combination of mice resulted marked increase neuroinflammation, which is...