A5006359064- Electron Spin Resonance Studies
- Lanthanide and Transition Metal Complexes
- Immunotherapy and Immune Responses
- Hemoglobin structure and function
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Erythrocyte Function and Pathophysiology
- Proteoglycans and glycosaminoglycans research
- Immune responses and vaccinations
- Synthetic Organic Chemistry Methods
- BRCA gene mutations in cancer
- Evolution and Genetic Dynamics
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Photoreceptor and optogenetics research
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Blood properties and coagulation
- RNA regulation and disease
- Melanoma and MAPK Pathways
- Advanced NMR Techniques and Applications
- Platelet Disorders and Treatments
- DNA and Nucleic Acid Chemistry
- Advanced MRI Techniques and Applications
- Heat shock proteins research
West Virginia University
2021-2025
Saint John's Health Center
2015-2020
Cincinnati Children's Hospital Medical Center
2016
California State Polytechnic University
2015
Yale University
2010
Bridgeport Hospital
2010
Heidelberg University
2010
In vivo measurement and mapping of oxygen levels within the tissues are crucial in understanding physiopathological processes numerous diseases, such as cancer, diabetes, or peripheral vascular diseases. Electron paramagnetic resonance (EPR) associated with biocompatible exogenous spin probes, Ox071 triarylmethyl (TAM) radical, is becoming new gold standard for preclinical settings. However, these probes do not show tissue selectivity when injected systemically, they cell permeable,...
Sulfated glycopolymers were synthesized from diisocyanates and lactose containing diamines. Blood compatibility assays indicated highly sulfated with methylene bis(4-cyclohexyl isocyanate) backbones result in prolonged clotting times.
Abstract Precise timing of sperm activation ensures the greatest likelihood fertilization. Precision in Caenorhabditis elegans is ensured by external signaling, which induces spherical spermatid to reorganize and extend a pseudopod for motility. Spermatid activation, also called spermiogenesis, prevented from occurring prematurely activity SPE-6 perhaps other proteins, termed “the brake model.” Here, we identify spe-47 gene hc198 mutation that causes premature spermiogenesis. The was...
Adjuvant immunotherapy in melanoma patients improves clinical outcomes. However, success is unpredictable due to inherited heterogeneity of immune responses. Inherent genes associated with single nucleotide polymorphisms (SNPs) may influence anti-tumor We assessed the predictive ability 26 immune-gene SNPs genomic panels for a response adjuvant BCG (Bacillus Calmette-Guérin) immunotherapy, using patient cohorts derived from three phase III multicenter trials: AJCC (American Joint Committee...
AimsVeterans from the 1990–91 Gulf War were exposed to acetylcholinesterase inhibitors (AChEIs), and, following service, an estimated one-third began suffering a medically unexplained, multi-symptom illness termed Illness (GWI). Previous research has developed validated rodent models that include exposure exogenous corticosterone (CORT) and AChEIs simulate high stress chemical exposures encountered in theater. This combination of mice resulted marked increase neuroinflammation, which is...
Abstract Background: Triple-negative breast cancer (TNBC) is characterized by high histologic grade, rates of distant recurrence and a poor overall prognosis. Treatment options are limited due to the lack specific targets such as hormone receptors or HER2 which drive other subtypes. Epidemiological studies show markedly higher prevalence TNBC in young women African ancestry. In this study we sought identify transcriptional modules that differentially regulated between American (AA) European...