A5015686624- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Ethnobotanical and Medicinal Plants Studies
- HIV/AIDS Research and Interventions
- Bioactive natural compounds
- Phytochemistry and Biological Activities
- African studies and sociopolitical issues
- Parasites and Host Interactions
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Traditional and Medicinal Uses of Annonaceae
- Transgenic Plants and Applications
- Mosquito-borne diseases and control
- Natural Compound Pharmacology Studies
- Phytochemical compounds biological activities
- Indigenous Knowledge Systems and Agriculture
- Synthesis of Indole Derivatives
- Chemical synthesis and alkaloids
- Insect Pest Control Strategies
- Insect Utilization and Effects
- Phytochemical Studies and Bioactivities
- Phytochemistry and Bioactive Compounds
- Bioactive Natural Diterpenoids Research
University of Botswana
2016-2025
Botswana Institute for Technology Research and Innovation
2012-2023
Université de Yaoundé I
2017
The continued burden of HIV in resource-limited regions such as parts sub-Saharan Africa, combined with adverse effects and potential risks resistance to existing antiretroviral therapies, emphasize the need identify new inhibitors. Here we performed a virtual screen molecules from pan-African Natural Product Library, largest collection medicinal plant-derived pure compounds on African continent. We identified eight structural similarity reported interactors Vpu, an HIV-1 accessory protein...
ABSTRACT New HIV latency-reversing agents (LRAs) are needed that can reactivate and/or eliminate reservoirs. “Mukungulu,” prepared from the plant Croton megalobotrys Müll Arg., is traditionally used for HIV/AIDS management in northern Botswana despite an abundance of protein kinase C-activating phorbol esters (“namushens”). Here, we show Mukungulu tolerated mice at up to 12.5 mg/kg while robustly reversing latency antiretroviral therapy (ART)-suppressed HIV-infected humanized 5 mg/kg. In...
Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylases, which have been linked to the pathogenesis of numerous diseases, including HIV, metabolic disorders, neurodegeneration and cancer. Docking virtual pan-African natural products library (p-ANAPL), followed by in vitro testing, resulted identification two inhibitors sirtuin 1, 2 3 (sirt1–3). Two bichalcones, known as rhuschalcone IV (8) an analogue I (9), previously isolated from medicinal plant Rhus...
Despite the remarkable progress in cancer therapy recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one most effective ways fight malignancies. cytotoxicity 14 compounds from African medicinal plants was evaluated four human carcinoma cell lines normal fibroblasts. tested samples included: β-spinasterol (1), friedelanone (2), 16β-hydroxylupeol (3), β-amyrin acetate (4), lupeol (5), sequoyitol (6), rhamnitrin...
Abstract A new polyprenylated benzophenone, named epunctanone ( 1 ), was isolated from the stem bark of Garcinia epunctata Stapf , together with eight known compounds, 7‐epiisogarcinol 2 2,6‐dimethoxy‐ p ‐benzoquinone 3 friedelin 4 lupeol 5 16 β ‐hydroxylupeol 6 betulin 7 stigmasterol 8 and rheediaxanthone 9 ). The structure ) established by detailed analysis its spectroscopic data, especially 1D‐ 2D‐NMR, HR‐MS data. All these compounds were evaluated for their antimicrobial anti‐protozoan...
Seven homoisoflavonoids and one stilbenoid, 3-(4′-methoxybenzyl)-6,7-dihydroxy-5-methoxychroman-4-one (1) which is new; 3-(4′-methoxybenzyl)-6-hydroxy-5,7-dimethoxychroman-4-one (2); 3-(4′-methoxybenzyl)-5,7-dimethoxychroman-4-one (3); 3-(3′-hydroxy-4′-methoxybenzyl)-5,7-dimethoxychroman-4-one (4); 3-(4′-methoxybenzylidene)-5,7-dihydroxy-6-methoxychroman-4-one (5); 3-(4′-hydroxybenzylidene)-5,7-dihydroxy-6-methoxychroman-4-one (6); 3-(4′-hydroxybenzylidene)-5,7-dihydroxychroman-4-one (7)...
The increasing prevalence of drug-resistant influenza viruses emphasizes the need for new antiviral countermeasures. M2 protein A is a proton-gated, proton-selective ion channel, which essential replication and an established target. However, all currently circulating virus strains are now resistant to licensed M2-targeting adamantane drugs, primarily due widespread variant encoding serine asparagine 31 mutation (S31N). To identify chemical leads that may target M2(S31N), we performed...
Aphloia theiformis is used in Makete district, Tanzania, and other areas by HIV AIDS patients as a weight loss remedy for treatment of tuberculosis. However, there no literature information on its antimycobacterial activity. To evaluate activity A. root ethanolic extract isolated compounds. The broth microdilution method was to test the crude against different non-pathogenic mycobacteria. Bioautography identify active constituents. Isolation compounds carried out using bioassay-guided...
Summary Current HIV latency reversing agents (LRAs) have had limited success in clinic, indicating the need for new strategies that can reactivate and/or eliminate reservoirs. “Mukungulu,” prepared from bark of Croton megalobotrys Müll. Arg., is traditionally used HIV/AIDS management Northern Botswana despite containing an abundance protein kinase C (PKC)-activating phorbol esters (“namushens”). Here we show Mukungulu tolerated mice at up to 12.5 mg/kg while potently antiretroviral therapy...
Ptycholobium is a genus related to Tephrosia which comprises only three species. Compared Tephrosia, has been phytochemically and pharmacologically studied, species have few or no reports on their chemical constituents. Moreover, studies the cytotoxic activities of its secondary metabolites previously documented.From non polar fractions roots bark contortum (syn contorta), two new pterocarpans: seputhecarpan C 1 D 2 pyrone derivative, ptycholopyrone A 3 were isolated. Alongside, five known...
Ozoroa insignis Del. is an ethnobotanical plant widely used in traditional medicine for various ailments, including schistosomiasis, tapeworm, and hookworm infections. From the so far not investigated fruits of insignis, anthelmintic principles could be isolated through bioassay-guided isolation using Caenorhabditis elegans identified by NMR spectroscopic analysis mass spectrometric studies. Isolated 6-[8(Z)-pentadecenyl] anacardic (1), 6-[10(Z)-heptadecenyl] acid (2), 3-[7(Z)-pentadecenyl]...
Schistosomiasis and soil-transmitted helminths are some of the priority neglected tropical diseases (NTDs) targeted for elimination by World Health Organization (WHO). They prevalent in Botswana although has begun mass drug administration with hope eliminating as a public health problem, prevalence schistosomiasis does not meet threshold required to warrant large-scale interventions. Although modern healthcare system, many people rely on traditional medicine treat worm infections...