A5012170969- Particle Dynamics in Fluid Flows
- Fluid Dynamics and Turbulent Flows
- Computational Fluid Dynamics and Aerodynamics
- Cancer Cells and Metastasis
- Aeolian processes and effects
- Epigenetics and DNA Methylation
- Gas Dynamics and Kinetic Theory
- Pancreatic and Hepatic Oncology Research
- Power Systems and Technologies
- Cancer Mechanisms and Therapy
- Granular flow and fluidized beds
- Mechanisms of cancer metastasis
- Surface Modification and Superhydrophobicity
- CRISPR and Genetic Engineering
- Fluid Dynamics and Heat Transfer
- Virus-based gene therapy research
- Fluid Dynamics and Thin Films
- Power Systems and Renewable Energy
- Combustion and flame dynamics
- Cloud Computing and Resource Management
- Speech and dialogue systems
- Maritime Transport Emissions and Efficiency
- Advanced Image Fusion Techniques
- Insect Pest Control Strategies
- Nanomaterials and Printing Technologies
Arizona State University
2021-2024
Johns Hopkins University
2018-2023
Johns Hopkins Medicine
2018-2023
Nanjing Forestry University
2022
University of Baltimore
2021
Southern Medical University
2021
Zhujiang Hospital
2021
Washington University in St. Louis
2017-2020
Yancheng Institute of Technology
2020
TCM-Intigrated Cancer Center of Southern Medical University
2014
High mobility group A1 (HMGA1) chromatin regulators are upregulated in diverse tumors where they portend adverse outcomes, although how function cancer remains unclear. Pancreatic ductal adenocarcinomas (PDACs) highly lethal characterized by dense desmoplastic stroma composed predominantly of cancer-associated fibroblasts and fibrotic tissue. Here, we uncover an epigenetic program whereby HMGA1 upregulates FGF19 during tumor progression formation. deficiency disrupts oncogenic properties...
Breast cancer already taken the first place of incidence in Chinese female patients. TRPM8 is found to be over-expressed breast cancer, but whether it promotes aggressiveness remains unknown. In our study, was identified highly expressing all tested cell lines including MCF-7, T47D, MDA-MB-231, BT549, SKBR3 and ZR-75-30, while just could detected MCF-10A, normal epithelial cell. Then four pairs clinical samples were analyzed using Western blotting result showed that expression higher tumor...
Real-time speech interaction, serving as a fundamental interface for human-machine collaboration, holds immense potential. However, current open-source models face limitations such high costs in voice data collection, weakness dynamic control, and limited intelligence. To address these challenges, this paper introduces Step-Audio, the first production-ready solution. Key contributions include: 1) 130B-parameter unified speech-text multi-modal model that achieves understanding generation,...
We investigate the effect of particle inertia on merger co-rotating dusty vortex pairs at semi-dilute concentrations. In a particle-free flow, is triggered once ratio core size to separation reaches critical value. The pair then decreases monotonically until two cores merge together. Using Eulerian–Lagrangian simulations particle-laden vortices, we show substantial departure from dynamics previously established in flows. Most strikingly, find that disperse particles with moderate cause push...
We investigate the effect of inertial particles on stability and decay a prototypical vortex tube, represented by two-dimensional Lamb–Oseen vortex. In absence particles, strong this flow makes it resilient to perturbations, whereby vorticity enstrophy at slow rate controlled viscosity. Using Eulerian–Lagrangian simulations, we show that dispersion semidilute accelerates tube orders magnitude. work, mass loading is unity, ensuring fluid particle phases are tightly coupled. Particle inertia...
Abstract BACKGROUND The whitefly Bemisia tabaci (Gennadius) is a severe pest that affects many field and glasshouse crops worldwide has developed resistance to insecticides in most chemical classes. Pymetrozine, neuroactive pyridine azomethine, selective towards piercing‐sucking pests Hemiptera. aim of this study was assess the B. Mediterranean (MED) pymetrozine laboratory. RESULTS After successive selection 18 generations MED presence using pymetrozine, there an 11.28‐fold increase median...
Fine tuned balance of reactive oxygen species (ROS) is essential for tumor cells and use immune checkpoints to evade attack form immunity system. However, it's unclear whether there any crosstalk between these two pathways. CYB561D2, an antioxidant protein, part 5-gene prognosis signature in gliomas its involvement unknown. Here, we aim provide a detailed characterization CYB561D2 gliomas.
We investigate the effect of inertial particles dispersed in a circular patch finite radius on stability two-dimensional Rankine vortex semi-dilute dusty flows. Unlike particle-free case where no unstable modes exist, we show that feedback force from triggers novel instability. The mechanisms driving instability are characterized using linear analysis for weakly and further validated against Eulerian-Lagrangian simulations. particle-laden is always if mass loading $M>0$. Surprisingly, even...
Abstract As electronic devices continue to shrink in size and increase functionality, effective thermal management has become a critical bottleneck that hinders continued advancement. Two-phase cooling technologies are of growing interest for electronics due their high heat removal capacity small resistance (<0.1 k cm2/W). One typical example two-phase method is droplet evaporation, which can provide transfer coefficient with low superheat. While evaporation been studied extensively used...
Intestinal organoid cultures provide a unique opportunity to investigate intestinal stem cell and crypt biology in vitro, although efficient approaches manipulate gene expression organoids have made limited progress this arena. While CRISPR/Cas9 technology allows for precise genome editing of cells generation, strategy requires extensive selection screening by sequence analysis, which is both time-consuming costly. Here, we detailed protocol viral transduction organoids. This approach rapid...
Intestinal organoid cultures provide a unique opportunity to investigate intestinal stem cell and crypt biology in vitro, although efficient approaches manipulate gene expression organoids have made limited progress this arena. While CRISPR/Cas9 technology allows for precise genome editing of cells generation, strategy requires extensive selection screening by sequence analysis, which is both time-consuming costly. Here, we detailed protocol viral transduction organoids. This approach rapid...
Abstract Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) (eg, gefitinib) exert potent therapeutic efficacy in non–small‐cell lung cancer (NSCLC) harboring EGFR‐activating mutations. However, the resistance to EGFR TKIs limits their clinical efficacy. TIP30, a newly identified tumor suppressor, appears be involved regulation of cytoplasmic and nuclear signaling NSCLC. Our previous study demonstrated that TIP30 regulated EGF‐dependent cyclin D1 transcription human...
As electronic devices continue to shrink in size and increase functionality, effective thermal management has become a critical bottleneck that hinders continued advancement. Two-phase cooling technologies are of growing interest for electronics due their high heat removal capacity small resistance (< 0.3 K-cm2/W) [1]. One typical example two-phase method is droplet evaporation, which can provide transfer coefficient with low superheat. While evaporation been studied extensively used many...
Power marketing service system data migration is the process of transferring from existing power to new system. This topic analyzes model and sorts out scope migration, reversely verifies integrity, accuracy, availability migrated based on business scenarios. According three-step method "migration, verification, defect elimination", estimate resources, optimize script performance, comprehensively evaluate distribution storage conditions, scheduling tasks, realize "automatic, one-click" which...
In a previous paper, AIAA 2019-1879, new one-equation eddy-viscosity model was derived from the two-equation k-kL model. this improvements to are described by optimizing constants. The improved is used simulate several benchmark canonical wall-bounded turbulent flows with small regions of separation. open-source software OpenFOAM for flowfield calculation. Grid independence solution study conducted on cases and influence grid accuracy assessed. It shown that one equation more accurate...
The differences of hygroscopic property among six tree species with four thicknesses were examined. density, chemical composition, crystallinity, equilibrium moisture content (EMC), and absorption rate measured by static saturated salt solution method, the isothermal curve was fitted H-H model to analyze monolayer molecular adsorption multilayer adsorption. results show that under same relative humidity (RH), EMC Picea asperata Populus deltoides increased increasing thickness, while Quercus...
At present, with the rapid development of digital technology, power enterprises need to improve business operation efficiency and management level help means. Based on urgent for real-time query electricity business, recovery statistics, bill list, sales briefing other businesses, this paper analyzes designs technical architecture data flow diagram library, carries out component verification from two aspects core competence typical scenarios, characteristics different technologies ADB...
We investigate the effect of particle inertia on merger co-rotating dusty vortex pairs at semi-dilute concentrations. In a particle-free flow, is triggered once ratio core size to separation reaches critical value. The pair then decreases monotonically until two cores merge together. Using Eulerian-Lagrangian simulations particle-laden vortices, we show substantial departure from dynamics previously established in flows. Most strikingly, find that disperse particles with moderate cause push...