A5036751703- Synthesis and Biological Evaluation
- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Traditional and Medicinal Uses of Annonaceae
- Organoselenium and organotellurium chemistry
- Chemical Synthesis and Analysis
- Marine Sponges and Natural Products
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Bariatric Surgery and Outcomes
- Gastric Cancer Management and Outcomes
- Selenium in Biological Systems
- Alkaloids: synthesis and pharmacology
- Fluorine in Organic Chemistry
- Redox biology and oxidative stress
- Advanced Glycation End Products research
- Medicinal plant effects and applications
- Radical Photochemical Reactions
- Ferrocene Chemistry and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Near-Field Optical Microscopy
Guangdong Ocean University
2022-2023
First Affiliated Hospital of Jinan University
2018-2023
Jinan University
2012-2018
University of North Carolina at Chapel Hill
1988
Real-time speech interaction, serving as a fundamental interface for human-machine collaboration, holds immense potential. However, current open-source models face limitations such high costs in voice data collection, weakness dynamic control, and limited intelligence. To address these challenges, this paper introduces Step-Audio, the first production-ready solution. Key contributions include: 1) 130B-parameter unified speech-text multi-modal model that achieves understanding generation,...
Introduction This study aimed to evaluate the adjuvant hypoglycemic function of enzyme hydrolyzate (EHCA) from Chlamys nobilis in mice and identify α -glucosidase inhibitory peptides. Methods The radical scavenging ability EHCA were determined vitro , effects on blood glucose regulation antioxidant activity evaluated vivo using a mouse model. Peptides with potential identified by LC-MS/MS confirmed silico . Results Discussion exhibited significant against 2,2-diphenyl-1-picrylhydrazyl...
Abstract The use of selenium‐containing heterocyclic compounds as potent cancer chemopreventive and chemotherapeutic agents has been well documented by a large number clinical studies. In this study we developed new approach to synthesize four benzimidazole‐containing selenadiazole derivatives (BSeDs). method uses combination peptide coupling reagents microwave irradiation. This strategy features milder reaction conditions, higher yields, shorter times. synthetic BSeDs were identified...
Herein we design a therapeutic nanoplatform as carriers of oncogene siRNA and chemotherapeutics to achieve precise cancer therapy.
The objective of the present study was to explore protective effects curcumin/cyclodextrin polymer (CUR/CDP) inclusion complex on hydrogen peroxide (H
Chemical drug design based on the biochemical characteristics of cancer cells has become an important strategy for discovery novel anticancer drugs to enhance targeting effects and biocompatibility, decrease toxic side effects. Camptothecin (CPT) demonstrated strong activity in clinical trials but also notorious adverse In this study, we presented a smart targeted delivery system (Biotin-ss-CPT) that consists cancer-targeted moiety (biotin), cleavable disulfide linker (S-S bond) active CPT....
Abstract Two new pentahydroxylated steroids, (3 β ,12 ,16 ,23 E )‐cholesta‐5,23‐diene‐3,12,16,20,25‐pentaol ( 1 ) and )‐cholesta‐5,25(26)‐diene‐3,12,16,20,24‐pentaol 2 ), were isolated from the EtOH extract of South China Sea gorgonian Subergorgia suberosa. In addition, four known steroids detected. The structures these compounds established by spectroscopic methods comparison their data with those related compounds. cyctotoxicities evaluated against selected cancer cell lines.
X-ray radiotherapy has been widely used in the treatment of cervical cancer, a common gynecologic malignant tumor. However, therapeutic efficacy tends to be indistinctive. One major reason for this is amplification dihydrofolate reductase (DHFR) gene, which causes an increase DHFR activity and attenuation effect. To solve problem, we synthesized series inhibitors derived from methotrexate (MTX) analogues as sensitizers. Activity screening revealed that compound 2a exerted best inhibitory...
Infectious diseases pose a major challenge to human health, and there is an urgent need develop new antimicrobial agents with excellent antibacterial activity. A series of novel triazolo[4,3-a]pyrazine derivatives were synthesized their structures characterized using various techniques, such as melting point, 1H 13C nuclear magnetic resonance spectroscopy, mass spectrometry, elemental analysis. All the compounds evaluated for in vitro activity microbroth dilution method. Among all tested...
Two new compounds have been isolated from Nephthea sp.collected Naozhou Islands of the South China Sea.Their structures were established as leucyl-N-methyl-leucyl-leucyl-N-methyl-leucine (1), (20S,22R)-progesterone-1,4diene-22-acetyl-3-one (2) by MS, IR, 1 H NMR, 13 C NMR (DEPT), HSQC, HMBC and NOE analysis.Both them are previously unknown showed weak cytotoxicity against cancer cell lines.
The first total synthesis of the furanolactam fuscain is reported. key step in was formation seven-membered lactam by acylation a furan ring using mild Lewis acid CuSO 4 ·5H 2 O.
When carbohydrates in aqueous solution combine with biological receptors, their interactions the binding site take place of previous solvent water. Free energies can therefore be considered to depend on free solvation interacting partners before and after complexation. Because contain so many polar substituents, overall preferences for surroundings are overwhelming, that they do not yield readily analysis properties. We decided eliminate most secondary hydroxyl groups compare distribution...
A fairly small-sized aryl nitrogen mustard–conjugated terpyridine is synthesized in only two steps as a ligand to chelate with RuCl 3 afford [Ru(tpy-CM) 2 ]Cl complex. This complex exhibits prominent antiproliferative activity toward several tumor cells. Further studies conclusively show that the suppresses human renal clear cell carcinoma cells (786-O cells) by inducing G1 phase cycle arrest and apoptosis. work provides synthetic therapeutic model for mustard-containing metal complexes.
Background: Recurrent pneumothorax is a prevalent issue following primary spontaneous (PSP) surgery. This study identifies risk factors for PSP recurrence after Methods: included participants who had undergone surgery at our hospital from February 2021 to 2024. Relevant demographic, clinical, radiological, and laboratory data were collected each participant, statistical analysis was performed using SPSS 29.0 software (SPSS Inc., Chicago, IL, USA). Chi-squared tests, t-tests, binary logistic...
Nitrogen mustards are important alkylating anticancer drugs used for neoplasms treatment. However, little research about the integration of luminophore into nitrogen mustard-based compounds both imaging and therapeutic application was reported. In this study, we report a series novel mustard-containing 1-furyl-2-en-1-one 1-thienyl-2-en-1-one derivatives as intramolecular charge transfer-based in subcellular localization antiproliferation toward lung cancer cells. The target products were...
Abstract Dihydromyricetin (DMY) is a health‐beneficial flavanonol in the family of flavonoids, extracted from Ampelopsis grossedentata (Hand.‐Mazz.) W. Wang. When investigating stability DMY Dulbecco's modified Eagle's medium (DMEM) solution at 37°C by LC‐MS/MS, four nitrogenous derivatives were found except for previously known dimers, oxidized products, and ring‐cleavage products DMY. Compound 1 (N‐DMY) was identified to be 4′‐amino (NH 2 )‐DMY based on MS NMR data. The formation mechanism...