A5045948382- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Child Nutrition and Water Access
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Neonatal and Maternal Infections
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Global Maternal and Child Health
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Infant Nutrition and Health
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory Support and Mechanisms
- Healthcare Systems and Reforms
- Ethics and Legal Issues in Pediatric Healthcare
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
Dr. D. Y. Patil Medical College, Hospital and Research Centre
2018-2024
College of Medicine & JNM Hospital
2024
King Edward Memorial Hospital Research Centre
2013-2023
Kasturba Hospital
2017
Pneumonia, the leading infectious cause of child mortality globally, mainly afflicts developing countries. This prospective observational study aimed to assess microorganisms associated with pneumonia in children aged <5 years and emerging A multicenter, case-control by GABRIEL (Global Approach Biological Research, Infectious diseases Epidemics Low-income countries) network was conducted between 2010 2014 Cambodia, China, Haiti, India (2 sites), Madagascar, Mali, Mongolia, Paraguay. Cases...
Rotavirus is the most common cause of moderate-to-severe infant diarrhoea in developing countries, resulting enormous morbidity, mortality, and economic burden. A bovine-human reassortant pentavalent rotavirus vaccine (BRV-PV) targeting globally strains was developed India tested a randomized, double-blind, placebo-controlled end-point driven Phase III efficacy clinical trial implemented at six sites across India. Infants 6 to 8 weeks age were randomized (1:1) receive three oral doses BRV-PV...
Rotavirus gastroenteritis is one of the leading causes diarrhea in Indian children less than 2 years age. The 116E rotavirus strain was developed as part Indo-US Vaccine Action Program and has undergone efficacy trials. This paper reports additional safety data up to In a double-blind placebo controlled multicenter trial, 6799 infants aged 6–7 weeks were randomized receive three doses an oral human-bovine natural reassortant vaccine (116E) or at ages 6, 10, 14 weeks. primary outcome severe...
Pneumonia is the leading cause of death in children. The objectives were to evaluate microbiological agents linked with hypoxemia hospitalized children pneumonia from developing countries, identify predictors hypoxemia, and characterize factors associated in-hospital mortality. A multicenter, observational study was conducted five hospitals, India (Lucknow, Vadu), Madagascar (Antananarivo), Mali (Bamako), Paraguay (San Lorenzo). Children aged 2-60 months radiologically confirmed enrolled...
Abstract Background Globally, community health workers (CHWs) are integral contributors to many systems. In India, Accredited Social Health Activists (ASHAs) have been deployed since 2005. Engaged in multiple care activities, they a key link between the system and population. ASHAs expected participate new programmes prompting interest their current workload from perspective of system, family. Methods This mixed-methods design study was conducted rural tribal Primary Centers (PHCs), Pune...
There are limited global data on head-to-head comparisons of vaccine platforms assessing both humoral and cellular immune responses, stratified by pre-vaccination serostatus. The COVID-19 vaccination drive for the Indian population in age group 18–45 years began April 2021 when seropositivity rates general were rising due to delta wave pandemic during April–May 2021. Between June 30, 2021, Jan 28, 2022, we enrolled 691 participants across four clinical sites India. In this non-randomised...
Post licensure studies have identified an increased risk of intussusception following vaccination with currently licensed rotavirus vaccines, raising safety concerns generic to all vaccines. We describe the surveillance for in a phase III clinical trial oral monovalent vaccine developed from neonatal 116E strain. Using broad screening criteria and active surveillance, incidence between 6 weeks 2 years age was measured 4532 children who received three doses 2267 placebo trial. Possible...
Importance The recombinant COVID-19 vaccine NVX-CoV2373 has demonstrated efficacy of approximately 90% in adults; however, its safety and children is unknown. Objective To assess the noninferiority SII-NVX-CoV2373 adolescents compared to adults evaluate comparison with placebo. Design, Setting, Participants This phase 2-3 observer-blind randomized clinical trial was conducted 2 cohorts, (aged 11 years) 12 17 between August 2021 2022. were 3:1 or placebo monitored for 179 days. participants,...
Abstract A fully liquid hexavalent containing Diphtheria (D), Tetanus (T) toxoids, whole cell Pertussis (wP), Hepatitis B (Hep B), type 1, 2, 3 of inactivated poliovirus (IPV) and Haemophilus influenzae b (Hib) conjugate vaccine (DTwP-HepB-IPV-Hib vaccine, HEXASIIL ® ) was tested for lot-to-lot consistency non-inferiority against licensed DTwP-HepB-Hib + IPV in an open label, randomized Phase II/III study. In III part, healthy infants received DTwP-HepB-IPV-Hib or vaccines at 6, 10 14 weeks...
Background The integration of digital health (eHealth) interventions into primary healthcare systems has gained recognition lately in Low- and Middle-Income Countries (LMICs) to enhance quality, accessibility, efficiency. These may offer effective strategies mitigating the burden chronic diseases by facilitating access remote optimising its processes. This scoping review aims identify assess eHealth implemented care settings LMICs for further development adaptation. Methods analysis We will...
Nasopharyngeal pneumococcal carriage in South Asian infants: Results of observational cohort studies vaccinated and unvaccinated populations
We conducted a randomized, non-inferiority, clinical study of MMR vaccine by disposable-syringe jet injector (DSJI) in toddlers India comparison with the conventional administration. was administered subcutaneously DSJI or needle-syringe (N-S) to (15–18 months) who had received measles at 9 months. Seropositivity measles, mumps, and rubella serum IgG antibodies assessed 35 days after vaccination. Non-inferiority concluded if upper limit 95% CI for difference percent seropositive between...
A newly developed bovine-human reassortant pentavalent vaccine (BRV-PV, ROTASIIL®) was tested for its potential effect on the immunogenicity of concomitantly administered EPI vaccines in infants a randomized controlled study India.In this Phase III, multicenter, open label, randomized, study, three doses BRV-PV or two Rotarix® and one dose placebo were given to healthy at 6, 10, 14 weeks age. Subjects also received DTwP-HepB-Hib (diphtheria, tetanus, whole-cell pertussis, hepatitis B,...
A heat-stable bovine-human rotavirus reassortant pentavalent vaccine (BRV-PV, ROTASIIL®) was developed in India. In this study, the tested for safety, immunogenicity and clinical lot-to-lot consistency. This a Phase III, open label, randomized, equivalence design study. The primary objective to demonstrate consistency of BRV-PV. Subjects were randomized into four arms, three arms received Lots A, B, C BRV-PV control arm, Rotarix®. Three doses or two Rotarix® one dose placebo given at 6, 10,...
We conducted a randomized, observer-blind, non-inferiority, parallel-group clinical study of diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae type b conjugate (pentavalent) vaccination infants in India. Goals were to determine whether the seropositivity rate after via disposable-syringe jet injector (DSJI) was non-inferior that needle syringe (N-S), compare safety by two methods.Healthy children received three-dose series vaccine intramuscularly DSJI or N-S beginning...
Routinely children are exposed to various procedures as a part of clinical care and/or research participation. Public health strategies contain current COVID-19 pandemic demanded massive nasopharyngeal swab testing but limited data exist confirm the extent pain and distress that result from this procedure. These could help clinicians formulate mitigation strategies, influence public directives, inform review boards/ethics committees decide on risk-benefit ratio Hence, an observational study...
Abstract Background Community health workers (CHW) contribute to achieving targets of the Sustainable Development Goals (SDG) and Universal Health Care (UHC) in low- middle-income countries (LMICs). In India, accredited social activists (ASHAs) function as facilitators, service providers, programme supporters for rural tribal communities are at frontline during COVID-19 pandemic. We aimed describe ASHAs' work roles both before pandemic, explore tasks ASHAs performed throughout understand its...
This article summarizes all aspects related to the exclusion and inclusion of pregnant women in clinical trials.Historically date, were observed as most excluded population from research.There are various scientific well ethical reasons behind their exclusion.However, given burden illnesses diseases during pregnancy, there is a need include them research.Available data regarding safety efficacy medicinal products also collected accidental exposure.But these evidences insufficient give...