A5047612676- Memory and Neural Mechanisms
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Aging and Gerontology Research
- Memory Processes and Influences
- Health disparities and outcomes
- Psychological Well-being and Life Satisfaction
- Neural dynamics and brain function
- Amyotrophic Lateral Sclerosis Research
- Frailty in Older Adults
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Ethics and bioethics in healthcare
- Identity, Memory, and Therapy
- Advanced Neuroimaging Techniques and Applications
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Epilepsy research and treatment
- Neurological diseases and metabolism
- Neurological and metabolic disorders
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and genetic disorders
San Francisco VA Medical Center
2020-2022
University Memory and Aging Center
2021
University of California, San Francisco
2021
University of Arizona
2015-2019
Objectives: Several risk and protective factors are associated with changes in cognitive functioning aging adults – including physical health, depression, activity, social activities though the findings for participation mixed. This study investigated longitudinal association between two domains of functioning, memory executive function. A primary goal our analyses was to determine whether predicted over-and-above activity a sample adequate power detect unique effects.Method: The included (N...
Physical activity (PA) is widely recommended for age-related brain health, yet its neurobiology not well understood. Animal models indicate PA synaptogenic. We examined the relationship between and synaptic integrity markers in older adults.Four hundred four decedents from Rush Memory Aging Project completed annual actigraphy monitoring (Mean visits = 3.5±2.4) post mortem evaluation. Brain tissue was analyzed presynaptic proteins (synaptophysin, synaptotagmin-1, vesicle-associated membrane...
Married couples evidence interdependence in their psychological and physical wellbeing across the life span. This is particularly true aging populations that experience declines health cognitive ability. study investigated effects of partners' cognition on quality (QoL) a series bivariate latent curve growth models. The sample included married (N = 8,187) who participated Survey Health, Ageing, Retirement Europe (SHARE) provided data 6 years. Results indicated husbands' wives' baseline...
Physical activity and body mass predict cognition in the elderly. However, mixed evidence suggests that obesity is associated with poorer cognition, while also protecting against cognitive decline older age. We investigated whether independently predicted age these associations changed over time. A latent curve structural equation modeling approach was used to analyze data from a sample of aging adults (N = 8442) split into two independent subsamples, collected 6 years. Lower baseline Body...
Aging adults experience declines in working memory and episodic memory, however, it is unclear how these operate over time. Decreased may be associated with early changes by reducing older adults' ability to meaningfully integrate new information into pre-existing schemas recall without the assistance of cues. Given increased prevalence Alzheimer's disease, concerns based on subjective changes, important understand processes interact To assess relationship between during healthy cognitive...
Abstract Unitization, the process of encoding previously independent units as one coherent representation, improves associative memory in both young and older adults, or some cases, differentially benefits adults. Unitization verbal pairs may reduce reliance on hippocampus (HC) for successful recognition by shifting to familiarity‐based processing mediated perirhinal cortex (PRC). However, this shift was not observed a recent study visual memory, with equivalent activation HC PRC during...
Abstract Introduction Physical activity (PA) is associated with better cognitive and brain health. However, it remains unclear whether PA relates to accumulation of disease pathology (“resistance”) or indirectly moderates adverse effects on cognition (“cognitive resilience”). Methods Five hundred thirteen Rush Memory Aging Project (MAP) decedents completed longitudinal actigraphy monitoring, testing, neuropathological examination. Cross‐sectional models tested the relationship between...
INTRODUCTION: Sex differences are apparent in neurodegenerative diseases, but have not been comprehensively characterized frontotemporal dementia (FTD). METHODS: Participants included 337 adults with autosomal dominant FTD enrolled the ALLFTD Consortium. Clinical assessments and plasma were collected annually for up to six years. Linear mixed-effects models investigated how sex disease stage associated longitudinal trajectories of cognition, function, neurofilament light chain (NfL)....
Abstract Pattern separation, the ability to differentiate new information from previously experienced similar information, is highly sensitive hippocampal structure and function declines with age. Functional MRI studies have demonstrated hyperactivation in older adults compared young, greater task‐related activation associated worse pattern separation performance. The current study was designed determine whether differences task‐free cerebral blood flow (CBF) 130 functionally intact adults....
Posttraumatic stress disorder (PTSD) is characterised by alterations in autobiographical memory for traumatic and non-traumatic events. Studies that focus on event construction – the ability to search identify a specific have documented overgeneral PTSD. However, quality of also depends elaborate an once constructed providing additional details. In prior study, individuals with PTSD generated as many episodic (event-specific) details trauma-exposed controls when demands were minimized,...
Abstract Background Verbal memory profiles are commonly characterized as reflective of frontal or medial temporal dysfunction in clinical practice. Frontal‐subcortical patterns marked by intrusion errors and impoverished recall that improves with cueing recognition. However, retrieval deficits, errors, learning also seen disorders affecting the lobes (MTL), such Alzheimer’s disease. The aim current study was to determine relative contribution prefrontal MTL structural integrity verbal...