A5033433779- Gout, Hyperuricemia, Uric Acid
- Foot and Ankle Surgery
- Cancer-related molecular mechanisms research
- Tendon Structure and Treatment
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Case Reports on Hematomas
- Peripheral Nerve Disorders
- Sports injuries and prevention
- Veterinary medicine and infectious diseases
- Per- and polyfluoroalkyl substances research
- Galectins and Cancer Biology
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- RNA Interference and Gene Delivery
- Myofascial pain diagnosis and treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Bee Products Chemical Analysis
Huashan Hospital
2020-2024
Fudan University
2020-2024
Affiliated Hospital of Qingdao University
2020-2024
Qingdao University
2020-2024
Jiangxi University of Traditional Chinese Medicine
2017-2024
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2024
University of Auckland
2023
Central South University
2021-2022
Zero to Three
2019
Objective Increasing evidence suggests that impaired cartilage is a substantial risk factor for the progression from hyperuricaemia to gout. Since relationship between matrix protein and gout flares remains unclear, we investigated its role in monosodium urate (MSU) crystallisation following inflammation. Methods Briefly, screened synovial fluid gouty arthritis patients with injuries. After identifying correlation crystals molecules, conducted image analysis classification of crystal...
Gout is a common metabolic disease with growing burden, caused by monosodium urate (MSU) microcrystal deposition. In situ and chemical-specific histological identification of MSU crucial in the diagnosis management gout, yet it remains inaccessible for current methods. Methods: Stimulated Raman scattering (SRS) microscopy was utilized to image based on its fingerprint spectra. We first tested SRS capability gout differentiation power from pseudogout rat models acute arthritis, calcium...
The prognostic value of polybromo 1 (PBRM1) gene mutations in clear cell renal carcinoma (CCRCC) with anti-programmed death-ligand (PD-L1) therapy remains controversial, and few studies have reported the impact PBRM1 other cancer types.The patient information was obtained from cBioPortal Tumor Immune Estimation Resource (TIMER) databases. Mann-Whitney U test were used for correlation analysis. For survival analyses, Kaplan-Meier curves compared using log-rank test. Cox's regression model to...
Abstract Background Immune checkpoint inhibitors (ICIs) have witnessed the achievements of convincing clinical benefits that feature significantly prolonged overall survival (OS) patients suffering from advanced non-small cell lung cancer (NSCLC), according to reports recently. Sensitivity immunotherapy is related several biomarkers, such as PD-L1 expression, TMB level, MSI-H and MMR. However, a further investigation into novel biomarkers prognosis on ICIs treatment required. In addition,...
AIMTo verify whether curcumin (Cur) can treat inflammatory bowel disease by regulating CD8 + CD11c+ cells. METHODSWe evaluated the suppressive effect of Cur on CD11c cells in spleen and Peyer's patches (PPs) colitis induced trinitrobenzene sulfonic acid.Mice with were treated 200 mg/kg for 7 d.On day 8, therapeutic was visual assessment histological examination, while co-stimulatory molecules PPs measured flow cytometry.The levels interleukin (IL)-10, interferon (IFN)-γ transforming growth...
Aryl benzofuranones are privileged structural units present in natural products and pharmaceutically relevant compounds with high bioactivity therapeutic value; synthetic access to these scaffolds remains an area of intensive interest. A new efficient TfOH-catalyzed cascade ortho C–H activation/lactonization phenols α-aryl-α-diazoacetates is reported. This metal-free protocol provides operationally simple rapid method for the one-pot assembly diverse α-aryl yields broad substrate scope, a...
Accurate inference of the relationship between non-coding RNAs (ncRNAs) and drug resistance is essential for understanding complicated mechanisms actions clinical treatment. Traditional biological experiments are time-consuming, laborious, minor in scale. Although several databases provide relevant resources, computational method predicting this type association has not yet been developed. In paper, we leverage verified data ncRNA to construct a bipartite graph then develop linear residual...
Joint deafferentation after post-ankle sprain ligament healing can disrupt sensory input from the ankle and induce maladaptive neuroplasticity, especially in cerebellum. This study aimed to determine whether regional homogeneity of intrinsic cerebellar activity differs between patients with instability healthy controls without a history injury.The current used primary data set 18 22 an external UK Biobank 16 69 for cross-database, cross-sectional investigation. All participants underwent...
To date, there are few biomechanical studies comparing the strength between knot repair and knotless procedures for anterior talofibular ligament (ATFL) injury.To perform a comparison of arthroscopic ATFL technique with or suture anchors in cadaveric model partial complete injuries.Controlled laboratory study.A total 24 fresh-frozen ankles were used. Arthroscopy was used to identify, section, on fibular insertion site. The specimens then randomly placed into 1 4 groups: group A received...
The prognosis of hepatocellular carcinoma (HCC) is extremely poor; therefore, there an urgent need for novel prognostic molecular biomarkers HCC. current investigation utilized circular (circ)RNA-associated competing endogenous (ce)RNAs analysis in order to identify significant HCC.CircRNAs and mRNAs that were differentially expressed between normal HCC tissues identified. Their respective functions predicted with Gene Ontology enrichment Kyoto Encyclopedia Genes Genomes analyses. A nomogram...
The research of anticancer drugs has gone through a long process development, but so far, no drug can cure cancer completely. resistance is one the main reasons for failure treatment. As relationship between miRNA and gradually revealed, more evidence shows that sensitivity cells to also affected by miRNA. Research on miRNA-drug associations overcome challenging clinical situation imposed resistance. However, traditional biological experiments are time-consuming expensive. Therefore, there...
Insertional Achilles tendinopathy (IAT) is a common finding in the clinic. However, consensus on its mechanism, pathological process, diagnosis, treatment, and rehabilitation lacking. Thus, Chinese Society of Sports Medicine organized invited experts representing fields ankle disease to jointly develop an expert IAT.A statement Medicine.A total 34 field sports medicine orthopaedics were participate compilation regarding IAT. Consensus was achieved according Delphi method. First, 10 working...
Animal models are valid for in vivo research on the pathophysiological process and drug screening of gout arthritis. Intra-articular injection monosodium urate (MSU) is most common method, while stable MSU deposition enveloped by inflammatory cells was rarely reported.To develop a modified gouty arthritis rat model characterized intra-articular continuous joint pain with minimally invasive method.A total twenty-four rats were randomly allocated into six groups. Three intervention groups...
Small nucleolar RNAs(snoRNAs) represent an abundant group of noncoding RNAs in the nucleolus eukaryotes. Recent studies revealed that snoRNAs play a significant role wide range diseases. Identifying snoRNA-disease associations can provide great insights into understanding disease and treatment boosting drug discovery development. Traditional methods using biological experiments are often usually small-scale time-consuming. Therefore, it is urgent to develop computational framework predict...
Abstract Introduction Efficient and complete debridement of intra-articular deposits monosodium urate crystals is rarely achieved by existing arthroscopic tools such as shavers or radiofrequency ablation, while cavitation technology represents a prospective solution for the non-invasive clearance adhesions at interfaces. Methods Simulation modeling was conducted to identify optimal parameters device, including nozzle diameters jet pressures. Gouty arthritis model established in twelve rats...
Lung cancer, one of the most frequently diagnosed cancers, causes a huge number mortalities globally. Among lung non-small cell cancer (NSCLC) is recorded. Despite accumulating research, molecular basis NSCLC progression remains poorly known. Therefore, we aim to assess function NCK1-AS1 in and elucidate mechanism. Firstly, quantified level tumors adjacent healthy tissues. was significantly upregulated tumors, which associated with poor prognosis patients. Silencing inhibited proliferation,...