A5015685602- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Obesity and Health Practices
- Body Contouring and Surgery
- Pharmacology and Obesity Treatment
- Gut microbiota and health
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Probiotics and Fermented Foods
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Neuroendocrine Tumor Research Advances
- Biochemical effects in animals
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Syndromes and Imprinting
- Thyroid Disorders and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Blood disorders and treatments
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
Columbia University Irving Medical Center
2020-2022
Kaiser Permanente
2020
Rockefeller University
2012-2018
Cornell University
2018
Howard Hughes Medical Institute
2012
Institute on Aging
2010
National Institute on Aging
2010
Johns Hopkins University
2010
Universidade Federal da Bahia
2006
University of Rochester Medical Center
2003-2004
Background: There has been a dramatic shift in use of bariatric procedures, but little is known about their long-term comparative effectiveness. Objective: To compare weight loss and safety among procedures. Design: Retrospective observational cohort study, January 2005 to September 2015. (ClinicalTrials.gov: NCT02741674) Setting: 41 health systems the National Patient-Centered Clinical Research Network. Participants: 65 093 patients aged 20 79 years with body mass index (BMI) 35 kg/m2 or...
Background Besides its well-established role in nerve cell survival and adaptive plasticity, brain-derived neurotrophic factor (BDNF) is also involved energy homeostasis cardiovascular regulation. Although BDNF present the systemic circulation, it unknown whether plasma correlates with circulating markers of dysregulated metabolism an adverse profile. Methodology/Principal Findings To determine indices metabolic health, we measured levels 496 middle-age elderly subjects (mean age ∼70),...
The thionamide antithyroid drugs methimazole and propylthiouracil are the mainstay of pharmacologic therapy for Graves' disease. However, little is known about rate use these prescribing practices physicians treating hyperthyroidism.The objective study was to examine frequency from years 1991 2008.The data were acquired by U.S. Food Drug Administration's Division Epidemiology through two databases: IMS National Sales Perspectives Surveillance Data, Inc. Vector One: database.There a 9-fold...
Data suggest that nutrient order during a meal significantly impacts postprandial glucose and insulin excursions in type 2 diabetes, while its effects prediabetes have not been reported. Fifteen participants with consumed the same on 3 days random order: carbohydrate first, followed 10 minutes later by protein vegetables (CF); (PVF); or first (VF). Blood was sampled for measurements at 0, 30, 60, 90, 120, 150 180 minutes. Incremental peaks were similarly attenuated >40% PVF VF conditions...
Bariatric surgery is the most effective treatment for severe obesity; yet it unclear whether long-term safety and comparative effectiveness of these operations differ across racial ethnic groups.To compare outcomes Roux-en-Y gastric bypass (RYGB) sleeve gastrectomy (SG) groups in National Patient-Centered Clinical Research Network (PCORnet) Study.This was a retrospective, observational, cohort study that comprised 25 health care systems PCORnet Study. Patients were adults adolescents aged 12...
Despite the high prevalence of obesity among middle-aged subjects, it is unclear if sex differences in middle age affect metabolic outcomes therapies. Accordingly, this study, obese female and male mice were randomized to one three groups: sleeve gastrectomy (SG), sham surgery ad libitum (SH-AL), or with weight matching SG through intermittent fasting calorie restriction (SH-IF). Comprehensive measures energy glucose homeostasis, including intake, body weight, expenditure, insulin tolerance,...
Abstract Background Sleeve gastrectomy (SG) is currently the most frequently performed bariatric surgery in United States. The majority of patients undergoing SG are middle aged women. Most preclinical models surgery, however, utilize juvenile male mice. A long-term characterization response mature wild type, obese female mice to has not been performed. Thus, we set out characterize SG. Methods Ten-month old C57bl/6J were randomized undergo SG, sham without caloric restriction (SH) or with...
Abstract Background Some degree of weight regain is typically observed in human patients who undergo Sleeve Gastrectomy (SG), even if the majority them do not return to their presurgical body weight. Although bariatric surgery are middle aged, most preclinical models utilize juvenile male mice. A long-term characterization response mature, wild type, obese mice SG has been performed. Methods Eight-month old C57bl/6J were randomized SG, sham without caloric restriction (SH) or with match...
ABSTRACT Although sleeve gastrectomy (SG) is the most commonly performed bariatric surgery in US, its mechanistic underpinnings have not been fully determined. Thus, we set out to investigate whether SG’s effects on peripheral sympathetic system could mediate metabolic of SG. The celiac-superior mesenteric ganglia (CSMG) lie juxtaposed stomach and supply innervation stomach, as well numerous intra-abdominal organs relevant metabolism. Here investigated SG CSMG. led degeneration neurons CSMG,...