A5062366402- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Immune responses and vaccinations
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- RNA and protein synthesis mechanisms
- Free Radicals and Antioxidants
- Extracellular vesicles in disease
- Bacteriophages and microbial interactions
- Circular RNAs in diseases
- Viral gastroenteritis research and epidemiology
- Toxin Mechanisms and Immunotoxins
- Sarcoidosis and Beryllium Toxicity Research
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Lysosomal Storage Disorders Research
- Systemic Sclerosis and Related Diseases
- Erythrocyte Function and Pathophysiology
- interferon and immune responses
- Invertebrate Immune Response Mechanisms
Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences
2010-2024
Central Research Institute
2019
Institute of Experimental Cardiology
2007-2009
The spread of drug-resistant forms TB dictates the need for surgical treatment in complex anti-tuberculosis measures Russia. Most often, intervention is performed case pulmonary tuberculoma or fibrotic cavitary tuberculosis (FCT). This study devoted to search biomarkers that characterize course disease patients. It assumed such will help surgeon decide on timing planned operation. A number serum microRNAs, potential regulators inflammation and fibrosis TB, selected basis PCR-Array analysis,...
mRNA vaccines have been shown to be effective in combating the COVID-19 pandemic. The amount of research on use mRNAs as preventive and therapeutic modalities has undergone explosive growth last few years. Nonetheless, issue stability molecules their translation efficiency remains incompletely resolved. These characteristics directly affect expression level a desired protein. Regulatory elements RNA—5′ 3′ untranslated regions (UTRs)—are responsible for efficiency. An optimal combination...
Background Infection with Mycobacterium tuberculosis (Mtb) results in different clinical outcomes ranging from asymptomatic containment to rapidly progressing (TB). The mechanisms controlling TB progression immunologically-competent hosts remain unclear. Methodology/Principal Findings To address these mechanisms, we analyzed a panel of genetically heterogeneous (A/SnxI/St) F2 mice, originating TB-highly-susceptible I/St and more resistant A/Sn mice. In mice the rates differed. that did not...
Abstract The generation of effector, IFN-γ producing T lymphocytes and their accumulation at sites infection are critical for host protection against various infectious diseases. activation differentiation naive into effector memory cells starts in lymphoid tissues, but it is not clear whether the Ag-experienced that leave lymph nodes (LN) mature or if they undergo further changes periphery. We have previously shown CD44highCD62Llow CD4 generated during course mycobacterial can be segregated...
IL-11 is multifunctional cytokine whose physiological role in the lungs during pulmonary tuberculosis (TB) poorly understood. Here, using vivo administration of specific antibodies against IL-11, we demonstrate for first time that blocking diminishes histopathology and neutrophilic infiltration lung tissue TB-infected genetically susceptible mice. Antibody treatment decreased levels other key inflammatory cytokines not belonging to Th1 axis, down-regulated mRNA expression. This suggests...
Earlier we demonstrated that blocking of interleukin 11 (IL-11) by systemic administration anti–IL-11 antibodies attenuates severity Mycobacterium tuberculosis infection in mice. The substitution W147A the IL-11 molecule creates form cytokine capable to disrupt gp130/IL11R signaling complex formation, thus serving as a high-affinity specific antagonist IL-11–mediated signaling. We hypothesized this mutant may serve an effective tool for inhibition native activity vivo. established...
mRNA vaccines turned out to be highly effective in combating the COVID-19 pandemic and other viral infections. Despite extensive study of last five years, issue safety their use is still relevant. The aimed assess immunogenicity two anti-tuberculosis vaccine doses female male rats 2 4 weeks after vaccination. Hematological biochemical parameters blood were determined within same timeframe. dose-dependent nature was confirmed both females males. Vaccination led moderate lymphopenia...
Tuberculosis is a deadly bacterial disease and the second most common cause of death from monoinfectious diseases worldwide. Comprehensive measures taken by health authorities in various countries recent decades have saved tens millions lives, but number new cases this infection has been steadily increasing last few years already exceeds 10 million annually. The development vaccines against tuberculosis priority area prevention disease. mRNA shown high efficacy COVID-19 other viral...
Tuberculosis (TB) remains a leading cause of infectious disease mortality worldwide, despite the COVID-19 pandemic. The mechanisms by which SARS-CoV-2 affects tuberculosis progression have not yet been established. Here, we compared level inflammation in wall tuberculoma and parenchymal lung tissue 30 patients diagnosed with without history 3 months after COVID-19. We also characterized TB activity these using panel TB-associated miRNAs. Histopathological changes were examined resection...
Tuberculosis, a disease caused by the bacterium Mycobacterium tuberculosis, is major public health concern. Innate and adaptive immunity provide robust defense against pathogens. However, M. which co-evolved with humans, has acquired many mechanisms to evade immune response ensure its intracellular existence long-term survival within host. Moreover, emerging evidence suggests that this secretive can alter expression of regulatory noncoding RNAs (including microRNAs), leading dysregulation...
Tuberculosis (TB) is currently the leading cause of death among bacterial infectious diseases. The spectrum disease manifestations depends on both host immune responses and ability Mycobacterium tuberculosis to resist it. Small non-coding RNAs are known regulate gene expression; however, their functional role in relationship M. with poorly understood. Here, we investigated effect small sRNAs MTS1338 MTS0997 properties by creating knockout strains. We also assessed survival wild type mutant...
Introduction. Sarcoidosis-associated pulmonary fibrosis still lacks biomarkers to predict progression. Whole-genome association studies and other genetic research over the past few years have identified several single nucleotide polymorphisms that are associated with an increased risk of developing fi brosis. In sarcoidosis, relatively reliable predictors disease activity include serum angiotensin-converting enzyme, soluble interleukin-2 receptor (sIL-2R) chitotriosidase. Levels inetrleukin-5...
S uchetom togo, chto adaptivnyj immunnyj otvet vazhen dlya kontrolya i ustraneniya virusnyh infekcij, vyzyvayushchih zabolevaniya u lyudej, krajne vazhna ocenka adaptivnogo otveta na SARS-CoV-2. Nejtralizuyushchie antitela T-limfocity CD4+/CD8+ sposobstvuyut kontrolyu Tuberkulez do sih por ostaetsya glavnoj prichinoj smerti sredi bakterial'nyh infekcij v mire. Na dannyj moment lechenie tuberkuleza oslozhneno koinfekciej COVID-19. Cel'yu raboty bylo issledovat' obrazovanie nejtralizuyushchih...
Aim. To study the role of extracellular matrix metabolic products (matrix metalloproteinases 7 and 9, type III collagen propeptide) as potential non-invasive biomarkers progressive fibrosis in interstitial lung diseases. Design. A cross-sectional study. Materials methods. The included 32 patients with diseases 8 healthy volunteers. Based on presence/absence signs progression over previous 6 months, were divided into two groups. All underwent forced spirometry, body plethysmography, diffusion...
mRNK-vakciny pokazali vysokuyu effektivnost' v bor'be s pandemiej COVID-19 i drugimi virusnymi infekciyami. Nesmotrya na intensivnoe izuchenie mRNK-vakcin poslednie pyat' let, vopros o bezopasnosti ih primeneniya vse eshche ostaetsya aktual'nym. Cel'yu raboty bylo ocenit' immunogennost' protivotuberkuleznoj mRNK vakciny dvuh dozah u samok samcov krys cherez 2 4 nedeli posle vakcinacii. V eti zhe sroki opredelyali gematologicheskie biohimicheskie pokazateli krovi. Podtverzhdena...
Targeted treatment of tuberculosis-associated lung damage requires an understanding the precise mechanisms immunopathology. A major obstacle to longitudinal study tuberculosis (TB) immunopathogenesis in humans is lack serial biopsies during disease progression and treatment, which could be used characterize local immune pathways involved tissue damage. Understanding immunobiology has largely been based on animal models. Our looked for signs inflammation TB patients’ biopsies. Results were...
The article represents the results of our study associations between polymorphic gene variants CYP3А4 cytochrome – *1B (rs2740574) and *1G (rs2242480) effectiveness safety chemotherapy 115 drug-resistant pulmonary TB patients. We established that patients with CYP3A4 more commonly demonstrated sputum conversion under bedaquiline-containing chemotherapy, including multi-drug resistance (MDR). However, these developed hemato-, hepato cardiotoxic adverse drug reactions. obtained do not exclude...
In 2015, more than 10% of tuberculosis (TB)-related deaths were attributable to M. with multiple drug-resistance (MDR-TB) and extensively (XDR-TB) (WHO 2016). combination insufficient commitment the treatment regimen, genetic heterogeneity clonality patient's tuberculosis, as well poor permeability granuloma for drug, can lead monotherapy, despite use several drugs, which further promotes spread MDR XDR-TB. Of particular concern is rapid resistance newly introduced into clinical practice...
Since 1924, BCG vaccine is used to protect children from the most severe forms of tuberculosis. At same time, protective effect in adults variable. The potential for revaccination with live further limited by rapid spread HIV infection. early-secreted Mycobacterium tuberculosis proteins have been extensively TB development, due their high immunogenicity and shown animal models. aim our study was evaluate opportunity increase anti-TB resistance experimental animals re-vaccination a new...
The protection against tuberculosis infection is largely determined by the ability of host tissue macrophages to limit growth and spread mycobacteria. Able multiply within macrophages, mycobacteria have developed a number protective mechanisms preventing phagosome-lysosome fusion, thereby evading damaging effects lysosomal enzymes. Saposins are small, acidic, thermostable, non-enzymatic glycoproteins that participate as co-fac-tors in degradation short oligosaccharide head group...
<b>Introduction:</b> Interstitial pneumonia and hypersensitive (HP) belong to heterogeneous group of interstitial lung diseases (ILD), where profibrotic/antifibrotic as well proinflammatory/anti-inflamatory imbalance is postulated. However, exact etiology these not fully understood, the alveolar epithelial cell injury dysregulated repair processes are suggested. The median survival patients ranges from 3.8 14 years depending form disease. Biomarkers may be helpful in identifying with...
Already about one hundred years BCG remains the only widely used tuberculosis (TB) vaccine. It is known that intensity of BCG-induced Th1 immune response decreases over time and comes to naught within 10-15 years. significantly distinguishes from vaccines providing a lifelong protection such as against poliomyelitis or measles, can be bound natural restriction duration persistence CD4+ T-cells. Data on insufficient ability stimulate life-long immunological memory accumulating. Earlier in our...