A5101771817- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cervical Cancer and HPV Research
- Amino Acid Enzymes and Metabolism
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Effects of Radiation Exposure
- Glutathione Transferases and Polymorphisms
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
Guizhou Provincial People's Hospital
2008-2022
Yangzhou University
2015-2021
Growing evidence has demonstrated that human epidermal growth factor receptor 2 (HER2) is involved in the radiation response to breast cancer. However, underlying mechanism remains elusive. Therefore, we investigated if HER2 overexpression associated with radiosensitivity of We constructed cancer cell lines differing expression by transducing cDNA or short hairpin RNA against HER2. then assessed and potential using proliferation assay, adhesion assays, anoikis colony formation western...
Serine hydroxymethyltransferase 2 (SHMT2) has a critical role in serine-glycine metabolism to drive cancer cell proliferation. Yet, the function of SHMT2 tumorigenesis, especially human colorectal (CRC) progression, remains largely unclear.CRC and paired normal samples were collected Department Colorectal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School Medicine, assessed by real-time polymerase chain reaction (qPCR) analysis, western blot (WB), immunohistochemistry (IHC)....
Banxia xiexin decoction (BXXX) is a classical Chinese herbal compound for the treatment of gastrointestinal diseases. Its ingredients are also considered helpful cancer rehabilitation. Here, we will explore regulatory mechanism BXXX acting on PD-L1 in gastric (GC).GC samples and general baseline data patients were collated. Immunohistochemical (IHC) detected expression programmed cell death-ligand 1(PD-L1), hypoxia-inducible factor-1 (HIF-1), epidermal growth factor receptor (EGFR),...
BACKGROUND AND PURPOSE: Breast cancer is now recognized as a clinically heterogeneous disease with wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether features are associated the histological tumor grade breast carcinomas in Western China. METHODS: retrospectively collected data from China Clinical Cooperation Group assessed associations between factors 8619 female patients. Patients were divided into two groups: I (tumor I/II) II III). Univariable...
The aim of the study was to explore feasibility performing sentinel lymph node biopsy (SLNB) using a carbon nanoparticle suspension (CNPS) after neoadjuvant chemotherapy in breast cancer patients.
The aim of the present study was to examine association between migration breast cancer cells in vitro and radiosensitivity by establishing a cell model with different migratory capacities. Transwell chambers 24-well plate were used separate MDA-MB-231 ZR-7530 establish models Subsequently, measured using radiation clone formation assay. Furthermore, differential gene expression determined microarray analysis. protein levels differentially expressed genes (DEGs) assessed western blot From...
Objective To investigate the expression of hypoxia-inducible 1 alpha(HIF-lα)and glucose transporter 1(Glut1)in human breast cancer and its relationship to proliferating cell nuclear antigen (PCNA)protein clinical pathologic factors.Methods Immunohistochemical staining was used measure HIF-lα.Glut1 PCNA in fibroadenoma,usual hyperplasia carcinoma.Results HIF-1α not found fibroadenoma hyperplastic Iesions.In contrast.the positive rate ductal carcinoma situ 55%(DCIS,11/20)and invasive...