DCN is a chondro-protective agent which displays inadequate oral bioavailability along with gastrointestinal side effects. It choice of drug for treatment osteoarthritis. Therefore, the objective this study was to develop and optimize loaded nanostructured lipid carrier (NLCs) topical delivery. NLCs were prepared by hot homogenization followed sonication method. The formulation optimized 2 factor 3 level central composite design taking two independent variables i.e. concentration stearic...

The present review aims to discuss comprehensively about the Human Metapneumovirus (HMPV) which is a respiratory pathogen belonging family Paramyxoviridae. Since December 2024, northern China has seen significant rise of diseases, including HMPV, particularly among youngsters. Chinese Center for Disease Control and Prevention stated that HMPV was responsible 6.2% positive disease tests 5.4% hospitalizations during this time. Similar increases in cases have been Malaysia, Kazakhstan, India,...

Liposome was found by Alec Bangham of Babraham Institute in Cambridge, England 1965.In 1990; drugs with liposome and Amphotericin B were approved Ireland. In 1995 America F.D.A liposor doxodubicin. 1965s, it well recognized that microscopic lipid vesicles, known as liposomes, could be utilized to encapsulate dyes for the purpose systemic administration drug targeting.Considerable progress made 1980s, engeneering liposomes circulate longer blood remain intact while doing so. The a spherical...

Abstract Background High lipophilicity and poor aqueous solubility are the endemic problems of new drug molecules. Sixty to seventy percent these drugs unable solubilize completely in media, or have very low permeability. This hampers their oral absorption further leads bioavailability. Various researches progress overcome limitations. Novel technologies like nano-carrier systems become popular for improving drugs. Main body Lipid-based formulations, among nano systems, taking pace...

The objective of the present study was to determine efficacy arecoline hydrobromide against Rhipicephalus (Boophilus) microplus. Larval packet test (LPT) performed on larvae produced from collected ticks. Adult immersion (AIT) live tick weight, mortality ticks, and inhibition oviposition hatching after application. Arecoline taken in different concentrations (i.e. 0.1, 0.5, 1.5, 2.5 5, 7.5, 10 12.5 mg/mL) evaluate its acaricidal activity. result LPT exhibited 100% at mg/mL concentration...

A non-apoptotic iron-dependent form of Regulated Cell Death (RCD) known as ferroptosis is brought on by an excess harmful lipid peroxides and iron overload. Inhibiting the antioxidant defense system results in overwhelming GSH dependent pathway building up Reactive Oxygen Species (ROS) that react with polyunsaturated fatty acids large quantities can both cause ferroptosis. Recent research has shown holds a great deal promise for preventing tumor cell resistance limiting growth spread....

This study aimed at exploring the current development status and problems of health emergency management Covid 19. Corona viruses are a family that cause illness such as respiratory diseases or gastrointestinal diseases. Respiratory can range from common cold to more severe diseases, Middle East Syndrome (MERS-CoV) Severe Acute Syndrome. COVID-19 is principally considered disease, but some infected people experience non-respiratory symptoms, stroke.

The present study was performed with an objective to determine acaricidal activity of Citrus limetta seed oil (CLO) against cattle tick Rhipicephalus microplus. mode action CLO determined by evaluating biochemical enzymatic levels in treated ticks. obtained extracting n-hexane as solvent soxhlet apparatus. active compounds were analyzed through Gas chromatography. Acaricidal evaluated using larval packet test (LPT) and adult immersion (AIT). Results chromatographic analysis showed that...

The objective of the present study was to determine efficacy cottonseed oil (CSO) against cattle tick (Rhipicephalus microplus). CSO characterized through GC-HRMS and acaricidal activity evaluated larval packet test adult immersion test. ticks were exposed different concentrations 0.1, 0.5, 1.5, 2.5 5, 7.5, 10 12.5% oil. analyses revealed presence fatty acid, vitamins, sterols, other compounds. It found that effective in killing 100% larvae ticks. can be developed form formulation for...

Martynia annua belongs to family Martyniaceae is an herbaceous annual plant, spread throughout India. It commonly known as the Cat's claw or Devil’s claw. In India, traditional healers used M. in treatment of epilepsy, inflammation, sore throat, burns, itching, skin affections and tuberculosis. contains alkaloids, tannins, saponins, glycosides, flavonoids, anthocyanins, amino acid, steroids phenols. The researcher scientifically documented various pharmacological activities such...

Abstract Background Arthritis is a disorder of change in joint architecture and ligament degeneration. Rheumatoid arthritis an autoimmune which body’s immune system targets own cells degrade them. Martynia annua L. has been used Indian traditional therapies for the treatment epilepsy, many types inflammations, respiratory infection, sore throat wound. The objective present study was to determine anti-inflammatory anti-arthritic activities M. ethanolic fruit extract. Methods extraction...

In the present study we have discussed around sixteen different animal models used worldwide for scientific research and new drug discovery. The main aim of using experimental in discovery is to establish provide evidence non-clinical 'proof-of-concept' safety, efficacy, target interest specific molecules. Experimental preparations developed one species purpose studying phenomena occurring another species. use serves better understand origins, pathology, overall nature comparable diseases...

The viral pandemic in India has presented a complex and challenging scenario since 2019, impacting the nation's public health, economy, social fabric. This abstract provides concise overview of key aspects concerning new virus H9N2. H9N2 is primarily an avian influenza virus, while it occasionally infected humans, those cases have generally been limited not shown sustained human-to-human transmission. paper explores structural components H9N2, determinant host tropism, antigenic...