Rhinocerebral mucormycosis is an uncommon, rapidly progressive, highly fatal sinus infection, usually occurring in immunocompromised hosts. We describe our clinical experience with nine such consecutive cases managed at centre, emphasis on identifying early diagnostic and prognostic features. Perinasal cellulitis/paraesthesia was the most frequent sign of disease, being evident least six cases. Periorbital oedema, mucopurulent rhinorrhoea nasal crusting were other manifestations. Concurrent...

Head and neck cancer care was analysed in 2167 unselected patients for management compliance outcome. Median age 55 years, with a male to female ratio of 5.5[ratio ]1. Major sites were oropharynx (32.4 per cent), larynx (19.8 oral (16.6 cent) hypopharynx (12.9 cent). Stage-wise distribution I–II=8.9 cent, III=20.6 cent IV=60.3 unstaged=10.2 cent. Squamous cell carcinoma the dominant histology 90.9 Clinic-based cancer-directed treatment decisions made 1905 patients: curative intent 53...

It has been seen that advanced stage oral squamous cell carcinoma is associated with impaired T‐cell function and higher antibody response. In order to find out if such immune disregulation alteration of T‐helper (Th) type CD4+ phenotype leading altered cytokine production, we studied the Th‐like profile in 35 patients 21 normal controls. Concomitant expression both Th1 Th2 genes was by reverse transcription Polymerase Chain Reaction (PCR) based amplification (RT‐PCR) mRNA extracted from...

Invasive aspergillosis, one of the common paranasal sinus fungal infections, often secondarily involves orbit. We report six such cases with orbital extension, all occurring in apparently immunocompetent hosts, to specifically address difficult diagnostic and therapeutic issues involved. Limited biopsy procedures were inconclusive, necessitating wide surgical excision establish histopathological diagnosis. Conservative debridement proved adequate for disease limited infero-medial compartment...

Abstract Background High lipophilicity and poor aqueous solubility are the endemic problems of new drug molecules. Sixty to seventy percent these drugs unable solubilize completely in media, or have very low permeability. This hampers their oral absorption further leads bioavailability. Various researches progress overcome limitations. Novel technologies like nano-carrier systems become popular for improving drugs. Main body Lipid-based formulations, among nano systems, taking pace...

Petroleum ether, dichloromethane and ethyl acetate soluble fractions were obtained through partitioning the crude methanolic extract of leaves Campsis radicans L. (Family. Bignoniaceae) followed by chromatographic separation secondary metabolites from them. A total five triterpene compounds i.e., corosolic acid methyl ester (1), β-amyrin (2), arjunolic (3), maslinic (4) 28-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]-2α,3α,19α-trihydroxy-12-en-28-ursolic (5) isolated their structures...

The aim of this study was to develop and evaluate the transdermal patch formulations nifedipine. containing nifedipine were prepared optimized with different ratios vinyl cellulose-derived polymers, drug contents, permeation enhancers. Among various formulations, formulation a 1:5 ratio ethyl cellulose polyvinyl pyrrolidone selected for ex vivo pharmacokinetic based on in vitro studies using stratum corneum pig's skin. cumulative percentage release after administration 71.43%, plasma...

Omeprazole pellets containing mucoadhesive tablets were developed by direct punch method. Three polymers namely hydroxypropylemethylcellulose K4M, sodium carboxy methylcellulose, carbopol-934P and ethyl cellulose used for preparation of which intended prolong action may be due to the attachment with intestinal mucosa relief from active duodenal ulcer. Mucoadhesive coated respective polymer Eudragit L100 fabricate enteric tablets. The prepared evaluated different physical parameters...

Abstract Four regimens of prophylactic antibiotics were utilized in 122 consecutive patients stages III and IV carcinoma the upper aero-digestive tract undergoing major resections a randomized single-blind study. Ampicillin, gentamicin, cephalexin metronidazole used different combinations for periods 5 or 10 days. A cephalexin-metronidazole protocol days was associated with lowest post-operative infection rate. Oral-oropharyngeal resection use pectoralis myocutaneous flap most important...

There is considerable controversy surrounding the optimum treatment of advanced hypopharyngeal cancers. Curative radiotherapy with surgical salvage in reserve an accepted protocol as also a combined surgery and radiotherapy. The present study retrospective analysis survival results 195 cases treated single centre. group comprised greater number pyriform fossa post-cricoid tumours whereas, curative had higher proportion posterior pharyngeal wall tumours. Actuarial two-year disease-free rates...

In a nine-year period 50 nasopharyngeal angiofibromas, of whom 13 had recurrent tumour, were treated surgically at the All India Institute Medical Sciences, New Delhi. A new staging system according to regions involved was used; 31 patients in tumour limited nasopharynx (Stage I) and those with superior spread into ethmoid or sphenoid sinuses IIA) their tumours removed by transpalatal route, alone combination other approaches. Tumours lateral extensions pterygopalatine infratemporal fossae...

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This study intended to explore the influence of formulation factors on physico-chemical properties quercetin-loaded liposomes and optimize fabrication environment. Thin film hydration technique was employed prepare liposome optimization done by 32 factorial designs combined with desirability function. Nine preparations were prepared using altered drug: lipid soyphosphatidylcholine: cholesterol (SPC: cholesterol) ratios assessed for entrapment efficacy vesicle size. The findings mean diameter...

Hibiscus rosasinensis (HR) is a shrub belonging to Malvaceae. The leaves of ethanolic extract HR exhibited antidiabetic activity. Mucilage present in HR. objective this research and evaluate the mucilage Leaves were collected slurry was prepared which precipitated using ethanol. precipitates separated dried. dried subjected various phytochemical physicochemical tests. extracted shows presence carbohydrates, reducing sugar whereas glycoside, alkaloids, steroids, flavonoids tannins absent....

The research work was mainly designed to determine the antifungal activity of curcumin, a potent bioactive phytoconstituent, obtained from Curcuma longa and explore possibilities its use as combination with commercially available synthetic drugs for better therapeutic actions. Fluconazole itraconazole were used model drug. Different combinations curcumin fluconazole well prepared subjected an screening study. carried out using Candida albicans fungal strain. MIC fluconazole, found be in...

This paper is a retrospective study of 15 patients with parapharyngeal neurofibromas operated over six year period. No patient presented neurological deficit. CT scans revealed well encapsulated moderately enhancing mass in ten cases. The tumour was removed by transcervical approach cases while five cervical-transpharyngeal route mandibulotomy used; three the latter group retropharyngeal. In two recurrence successfully excised. It realized that required when internal carotid displaced...